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Träfflista för sökning "WFRF:(Nilsson Ulrika) srt2:(2000-2004)"

Sökning: WFRF:(Nilsson Ulrika) > (2000-2004)

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  • Johansson, Ulrika, 1974-, et al. (författare)
  • Inflammatory mediators expressed in human islets of Langerhans : implications for islet transplantation
  • 2003
  • Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 308:3, s. 474-479
  • Tidskriftsartikel (refereegranskat)abstract
    •   Expression of immune modulating mediators in human Islets of Langerhans could have important implications for development of autoimmunity in type 1 diabetes and influence the outcome of clinical islet transplantation. Islets obtained from five donors were analyzed at various times after isolation using cDNA array technology. The Atlas Human Cytokine/Receptor and Hematology/Immunology nylon membranes representing 268 genes and 406, respectively, were used and the relative expression of each gene analyzed. Of the 51 gene products identified, high mRNA expression of MCP-1, MIF, VEGF, and thymosin beta-10 was detected in all islet samples. IL-8, IL-1-beta, IL-5R, and INF-gamma antagonist were expressed in islets cultured for 2 days. IL-2R was expressed in islets cultured for more than 6 days. In conclusion, several inflammatory mediators were expressed in isolated islets, particularly at an early stage after isolation, indicating that a few days of culture could be beneficial for the outcome of islet transplantation.  
  • Molin, Daniel, et al. (författare)
  • Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease
  • 2001
  • Ingår i: British Journal of Haematology. - 0007-1048 .- 1365-2141. ; 114:3, s. 616-623
  • Tidskriftsartikel (refereegranskat)abstract
    • Hodgkin's disease (HD) tumours are characterized by the presence of few tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, surrounded by a large amount of non-neoplastic cells. The role of this cell infiltrate for the development of HD is not known. CD30, belonging to the tumour necrosis factor receptor superfamily, is highly expressed on HRS cells and believed to be involved in tumourigenesis and tumour progression. Tumour samples from 42 patients were immunohistochemically double-stained for tryptase, a mast cell-specific proteinase and CD30 ligand (CD30L). Tryptase-positive mast cells were present in all tumours. Of these cells, 50% expressed CD30L and 66% of the CD30L-positive cells were mast cells. CD30L mRNA in in vitro developed normal mast cells and malignant human and murine mast cell lines was detected using reverse transcription polymerase chain reaction. CD30L protein expressed on human mast cells was detected using flow cytometry. In a co-culture assay, the human mast cell line HMC-1 stimulated thymidine uptake in HRS cell lines, and the stimulation could be blocked using CD30L-specific monoclonal antibodies. In conclusion, mast cells are present in HD tumours and are the predominant CD30L-expressing cells. CD30L-CD30 interaction is a pathway by which mast cells may stimulate DNA synthesis in HRS cells.
  • Movérare, Sofia, et al. (författare)
  • Estren is a selective estrogen receptor modulator with transcriptional activity.
  • 2003
  • Ingår i: Molecular pharmacology. - 0026-895X .- 1521-0111. ; 64:6, s. 1428-33
  • Tidskriftsartikel (refereegranskat)abstract
    • It was recently reported that the synthetic compound estren increases bone mass without affecting reproductive organs or classic transcription. The aim of the present study was to further characterize the in vivo and in vitro effects of estren. We demonstrate that estren is a selective estrogen receptor modulator (SERM) with a strong effect on thymus, a moderate effect on uterus and trabecular bone, but no major effect on fat or cortical bone in 11-month-old ovariectomized mice. The effect of estren on trabecular bone and uterus is mediated via estrogen receptors (ERs) because no effect is seen in ER double-inactivated mice. Furthermore, with the use of ERalpha- and ERbeta-expressing reporter cell lines, we demonstrate that estren displays an agonistic effect on transcriptional activity of an estrogen-responsive element-driven reporter gene with a degree of agonism similar to that of 17beta-estradiol for both ERalpha and ERbeta. Thus, estren has the capacity to exert genomic effects via both ERalpha and ERbeta. We conclude, in contrast to what was previously reported by others, that estren is a SERM with transcriptional activity.
  • Björklund, Jonas, et al. (författare)
  • Selective determination of organophosphate flame-retardants and plasticizers in indoor air by gas chromatography, positive-ion chemical ionization and collision-induced dissosiation mass spectrometry
  • 2004
  • Ingår i: Rapid Communications in Mass Spectrometry. - 0951-4198 .- 1097-0231. ; 18:24, s. 3079-3083
  • Tidskriftsartikel (refereegranskat)abstract
    • Gas chromatography/ion trap mass spectrometry with in-source ionization and dissociation was used in positive-ion chemical ionization (PICI) mode for the determination of organophosphate triesters in indoor air. These compounds are widely used as additive flame retardants and plasticizers in different types of materials and have become ubiquitous pollutants in indoor environments. When using collision-induced dissociation in PICI mode the fragmentation of the organophosphate triesters can be performed in a more controllable way than in electron ionization (EI) mode. The developed selected-reaction monitoring method provided high selectivity for the investigated compounds. For 8-h air measurements (corresponding to 1.5 m3 of sampled air) the limit of detection of the method was determined to be in the range 0.1–1.4 ng m−3, which is comparable with nitrogen-phosphorus detection and about 50-fold lower than when using EI in selected-ion monitoring mode. The presented method was applied to samples from three common indoor environments, in which a number of organophosphate triesters were identified and quantified. The dominating compound was found to be tris(2-chloropropyl) phosphate, which occurred at levels up to 0.8 μg m−3.
  • Bümming, Per, 1965, et al. (författare)
  • Neoadjuvant, adjuvant and palliative treatment of gastrointestinal stromal tumours (GIST) with imatinib: a centre-based study of 17 patients.
  • 2003
  • Ingår i: British journal of cancer. - 0007-0920. ; 89:3, s. 460-4
  • Tidskriftsartikel (refereegranskat)abstract
    • Malignant gastrointestinal stromal tumours (GIST) have a poor prognosis. Since these tumours are resistant to conventional radiation and chemotherapy, surgery has been the mainstay of treatment. However, surgery is usually inadequate for the treatment of malignant GIST. Imatinib, a KIT tyrosine kinase inhibitor, has recently been found to have a dramatic antitumour effect on GIST. In this centre-based study of 17 consecutive patients with high-risk or overtly malignant GIST, imatinib was used in three different settings - palliatively, adjuvantly, and neoadjuvantly. The treatment was found to be safe and particularly effective in tumours with activating mutations of exon 11 of the KIT gene. Clinical response to imatinib treatment correlated morphologically to tumour necrosis, hyalinisation, and reduced proliferative activity. The value of neoadjuvant imatinib treatment was illustrated in one case.
  • Bäckström, Mattias, et al. (författare)
  • Speciation of heavy metals in road runoff and roadside total deposition
  • 2003
  • Ingår i: Water, Air and Soil Pollution. - 0049-6979 .- 1573-2932. ; 147:1-4, s. 343-366
  • Tidskriftsartikel (refereegranskat)abstract
    • The concentrations of Cd, Co, Cu, Pb, W and Zn were measured in road runoff and total deposition at two Swedish field sites during one year. It was found that the concentrations of most elements increased significantly during the winter, up to one order of magnitude. For cobalt and tungsten, it was found that around 90% of the total mass transport occurred during the winter, whereas for Cu, Pb, Cd, Zn and Na, the corresponding figures were 70–90, 40–80, 60–90, 50–70 and >99% depending on site specific conditions. The deicing salts (rock salts) did not significantly contribute to the increase in trace element concentrations. Instead, the increased concentrations were due to more intense wearing of the pavement during the winter because of the use of studded tires in combination with the chemical effects caused by the use of deicing salts. New potential elemental markers for roads and traffic are suggested.
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