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Träfflista för sökning "WFRF:(Nygren Peter) ;srt2:(2015-2019)"

Sökning: WFRF:(Nygren Peter) > (2015-2019)

  • Resultat 31-40 av 67
  • Föregående 123[4]567Nästa
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31.
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32.
  • Eriksson, Anna, 1977-, et al. (författare)
  • Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
  • 2017
  • Ingår i: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. - 0145-2126 .- 1873-5835. ; 63, s. 41-46
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We previously reported that the anti-malarial drug quinacrine has potential to be repositioned for treatment of acute myeloid leukemia (AML). As a next step towards clinical use, we assessed the efficacy of quinacrine in an AML-PS mouse model and investigated possible synergistic effects when combining quinacrine with nine other antileukemic compounds in two AML cell lines. Furthermore, we explored the in vivo activity of quinacrine in combination with the widely used AML agent cytarabine. The in vivo use of quinacrine (100mg/kg three times per week for two consecutive weeks) significantly suppressed circulating blast cells at days 30/31 and increased the median survival time (MST). The in vitro drug combination analysis yielded promising synergistic interactions when combining quinacrine with cytarabine, azacitidine and geldanamycin. Finally, combining quinacrine with cytarabine in vivo showed a significant decrease in circulating leukemic blast cells and increased MST compared to the effect of either drug used alone, thus supporting the findings from the in vitro combination experiments. Taken together, the repositioning potential of quinacrine for treatment of AML is reinforced by demonstrating significant in vivo activity and promising synergies when quinacrine is combined with different agents, including cytarabine, the hypomethylating agent azacitidine and HSP-90 inhibitor geldanamycin.</p>
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33.
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35.
  • Forslund, Marina, et al. (författare)
  • Effects of a nutrition intervention on acute and late bowel symptoms and health-related quality of life up to 24 months post radiotherapy in patients with prostate cancer : a multicentre randomised controlled trial.
  • 2019
  • Ingår i: Supportive Care in Cancer. - 0941-4355 .- 1433-7339.
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>PURPOSE:</strong> Radiotherapy to the prostate gland and pelvic lymph nodes may cause acute and late bowel symptoms and diminish quality of life. The aim was to study the effects of a nutrition intervention on bowel symptoms and health-related quality of life, compared with standard care.</p><p><strong>METHODS:</strong> Patients were randomised to a nutrition intervention (n = 92) aiming to replace insoluble fibres with soluble and reduce intake of lactose, or a standard care group (n = 88) who were recommended to maintain their habitual diet. Bowel symptoms, health-related quality of life and intake of fibre and lactose-containing foods were assessed up to 24 months after radiotherapy completion. Multiple linear regression was used to analyse the effects of the nutrition intervention on bowel symptoms during the acute (up to 2 months post radiotherapy) and the late (7 to 24 months post radiotherapy) phase.</p><p><strong>RESULTS:</strong> Most symptoms and functioning worsened during the acute phase, and improved during the late phase in both the intervention and standard care groups. The nutrition intervention was associated with less blood in stools (p = 0.047), flatulence (p = 0.014) and increased loss of appetite (p = 0.018) during the acute phase, and more bloated abdomen in the late phase (p = 0.029). However, these associations were clinically trivial or small.</p><p><strong>CONCLUSIONS:</strong> The effect of the nutrition intervention related to dietary fibre and lactose on bowel symptoms from pelvic RT was small and inconclusive, although some minor and transient improvements were observed. The results do not support routine nutrition intervention of this type to reduce adverse effects from pelvic radiotherapy.</p>
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36.
  • Giritli Nygren, Katarina, 1971-, et al. (författare)
  • Framåtblickande förändringsorienterade fantasier
  • 2017
  • Ingår i: Hållbarhetens många ansikten : samtal, forskning och fantasier. - Sundsvall : Mid Sweden University. - 978-91-88527-37-0 ; s. 132-133
  • Bokkapitel (övrigt vetenskapligt)
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38.
  • Giritli Nygren, Katarina, 1971-, et al. (författare)
  • Ömtålighetshållbar, långtänkt,ibland-lösningar…
  • 2017
  • Ingår i: Hållbarhetens många ansikten : samtal, forskning och fantasier. - Sundsvall : Mid Sweden University. - 978-91-88527-37-0 ; s. 142-143
  • Bokkapitel (övrigt vetenskapligt)
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39.
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40.
  • Godskesen, Tove, et al. (författare)
  • Differences in trial knowledge and motives for participation among cancer patients in phase 3 clinical trials
  • 2016
  • Ingår i: European Journal of Cancer Care. - 0961-5423 .- 1365-2354. ; 25:3, s. 516-523
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>While participants in clinical oncology trials are essential for the advancement of cancer therapies, factors decisive for patient participation have been described but need further investigation, particularly in the case of phase 3 studies. The aim of this study was to investigate differences in trial knowledge and motives for participation in phase 3 clinical cancer trials in relation to gender, age, education levels and former trial experience. The results of a questionnaire returned from 88 of 96 patients (92%) were analysed using the Mann-Whitney U-test. There were small, barely relevant differences in trial knowledge among patients when stratified by gender, age or education. Participants with former trial experience were less aware about the right to withdraw. Male participants and those aged ≥65 years were significantly more motivated by a feeling of duty, or by the opinions of close ones. Men seem more motivated than women by external factors. With the awareness that elderly and single male participants might be a vulnerable group and participants with former trial experience are less likely to be sufficiently informed, the information consent process should focus more on these patients. We conclude that the informed consent process seems to work well, with good results within most subgroups.</p>
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