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Sökning: WFRF:(Persson Anders) > Engelska > (2005-2009)

  • Resultat 1-10 av 243
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  • Gjörloff Wingren, Anette, et al. (författare)
  • Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: Higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN
  • 2007
  • Ingår i: Leukemia Lymphoma. - InformaWorld. - 1042-8194. ; 48:11, s. 2221-32
  • Tidskriftsartikel (refereegranskat)abstract
    • Patients diagnosed with diffuse large B-cell lymphoma (DLBCL) show varying responses to conventional therapy, and this might be contributed to the differentiation stage of the tumor B-cells. The aim of the current study was to evaluate a panel of kinases (ZAP70, PKC-beta I and II and phosphorylated PKB/Akt) and phosphatases (PTEN, SHP1 and SHP2) known to be frequently deregulated in lymphoid malignancies. De novo DLBCL cases were divided into two subgroups, the germinal center (GC) group (14/28) and the non-germinal center (non-GC) or activated B-cell (ABC) group (14/28). ZAP70 and PKC-beta II were expressed in a significantly higher percentage of tumor cells in the clinically more aggressive non-GC group compared with the prognostically favourable GC group. Also, the subcellular localization of PKC-beta I and II differed in DLBCL cells, with the PKC-beta I isoform being expressed in both the cytoplasm and nucleus, while PKC-beta II was found exclusively in the cytoplasm. Loss of nuclear PTEN correlated with poor survival in cases from both subgroups. In addition, five cell lines of DLBCL origin were analyzed for protein expression and for mRNA levels of PTEN and SHP1. For the first time, we show that ZAP70 is expressed in a higher percentage of tumor cells in the aggressive non-GC subgroup of DLBCL and that PKC-beta I and II are differently distributed in the two prognostic subgroups of de novo DLBCL.
  • Ljung, Patric, 1968-, et al. (författare)
  • Forensic Virtual Autopsies by Direct Volume Rendering
  • 2007
  • Ingår i: IEEE signal processing magazine (Print). - Piscataway, NJ, USA : IEEE. - 1053-5888. ; 24:6, s. 112-116
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • This paper presents state-of-the-art methods, which address the technical challenges in visualizing large three-dimensional (3D) data and enable rendering at interactive frame rates.
  • Ljung, Patric, 1968-, et al. (författare)
  • Full Body Virtual Autopsies Using A State-of-the-art Volume Rendering Pipeline
  • 2006
  • Ingår i: IEEE Transactions on Visualization and Computer Graphics. - 1077-2626. ; 12:5, s. 869-876
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • This paper presents a procedure for virtual autopsies based on interactive 3D visualizations of large scale, high resolutiondata from CT-scans of human cadavers. The procedure is described using examples from forensic medicine and the added valueand future potential of virtual autopsies is shown from a medical and forensic perspective. Based on the technical demands ofthe procedure state-of-the-art volume rendering techniques are applied and refined to enable real-time, full body virtual autopsiesinvolving gigabyte sized data on standard GPUs. The techniques applied include transfer function based data reduction using levelof-detail selection and multi-resolution rendering techniques. The paper also describes a data management component for large,out-of-core data sets and an extension to the GPU-based raycaster for efficient dual TF rendering. Detailed benchmarks of thepipeline are presented using data sets from forensic cases.
  • Lundin (Palmerius), Karljohan, 1977-, et al. (författare)
  • Enabling design and interactive selection of haptic modes
  • 2007
  • Ingår i: Virtual Reality. - 1359-4338.
  • Tidskriftsartikel (refereegranskat)abstract
    • The ever increasing size and complexity of volumetric data in a wide range of disciplines makes it useful to augment volume visualization tools with alternative modalities. Studies have shown that introducing haptics can significantly increase both exploration speed and precision. It is also capable of conveying material properties of data and thus has great potential to improve user performance in volume data exploration. In this paper we describe how recent advances in volume haptics can be used to build haptic modes-building blocks for haptic schemes. These modes have been used as base components of a toolkit allowing for more efficient development of haptic prototypes and applications. This toolkit allows interactive construction, configuration and fine-tuning of both visual and haptic representations of the data. The technology is also used in a pilot study to determine the most important issues and aspects in haptic volume data interaction and exploration, and how the use of haptic modes can facilitate the implementation of effective haptic schemes.
  • Lundström, Claes, 1973-, et al. (författare)
  • The alpha-histogram: Using Spatial Coherence to Enhance Histograms and Transfer Function Design
  • 2006
  • Ingår i: Proceedings Eurographics/IEEE Symposium on Visualization 2006, Lisbon, Portugal. ; s. 227-234
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • The high complexity of Transfer Function (TF) design is a major obstacle to widespread routine use of Direct Volume Rendering, particularly in the case of medical imaging. Both manual and automatic TF design schemes would benefit greatly from a fast and simple method for detection of tissue value ranges. To this end, we introduce the a-histogram, an enhancement that amplifies ranges corresponding to spatially coherent materials. The properties of the a-histogram have been explored for synthetic data sets and then successfully used to detect vessels in 20 Magnetic Resonance angiographies, proving the potential of this approach as a fast and simple technique for histogram enhancement in general and for TF construction in particular.
  • Lundström, Claes, 1973-, et al. (författare)
  • Uncertainty Visualization in Medical Volume Rendering Using Probabilistic Animation
  • 2007
  • Ingår i: IEEE Transactions on Visualization and Computer Graphics. - 1077-2626. ; 13:6, s. 1648-1655
  • Tidskriftsartikel (refereegranskat)abstract
    • Direct volume rendering has proved to be an effective visualization method for medical data sets and has reached wide-spread clinical use. The diagnostic exploration, in essence, corresponds to a tissue classification task, which is often complex and time-consuming. Moreover, a major problem is the lack of information on the uncertainty of the classification, which can have dramatic consequences for the diagnosis. In this paper this problem is addressed by proposing animation methods to convey uncertainty in the rendering. The foundation is a probabilistic Transfer Function model which allows for direct user interaction with the classification. The rendering is animated by sampling the probability domain over time, which results in varying appearance for uncertain regions. A particularly promising application of this technique is a "sensitivity lens" applied to focus regions in the data set. The methods have been evaluated by radiologists in a study simulating the clinical task of stenosis assessment, in which the animation technique is shown to outperform traditional rendering in terms of assessment accuracy.
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