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Sökning: WFRF:(Ramqvist Torbjörn) > (2010-2014)

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1.
  • Du, Juan, et al. (författare)
  • Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden
  • 2012
  • Ingår i: Emerging Infectious Diseases. - Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 18:9, s. 1468-1471
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Human papillomavirus (HPV) causes cervical, head, and neck cancers. We studied 483 patients at a youth clinic in Stockholm, Sweden, and found oral HPV prevalence was 9.3% and significantly higher for female youth with than without cervical HPV infection (p = 0.043). Most oral HPV types matched the co-occurring cervical types.</p>
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2.
  • Josefsson, Torbjörn, et al. (författare)
  • The history of early cereal cultivation in northernmost Fennoscandia as indicated by palynological research
  • 2014
  • Ingår i: Vegetation History and Archaeobotany. - Springer-Verlag New York. - 0939-6314 .- 1617-6278. ; 23:6, s. 821-840
  • Forskningsöversikt (refereegranskat)abstract
    • <p>The age of the introduction of cereal cultivation in northern Europe has long been debated by researchers from many disciplines, in particular archaeology and palaeoecology. Over the past 40 years extensive palynological data have been collected concerning pre-industrial land use in northern Fennoscandia. This paper reviews palynological studies that include records of fossil cereal pollen from northernmost Sweden, Finland and Norway at latitudes north of 63A degrees N. The geographical extent of known early cultivation sites is constantly expanding, with more than 100 records of cereal pollen pre-dating ad 1700. The oldest records of scattered cereal pollen derive from Neolithic times. Periods of continuous cultivation, indicated by cereal pollen recorded recurrently in the sediment profiles, derive from the Late Neolithic and Early Bronze Age. Collectively, the reviewed pollen records indicate that cereal cultivation was first introduced into areas close to the coast and later to the interior, and that it may have been practiced locally long before sedentary settlements based on intensive cultivation were established during medieval times. The data do not indicate a latitudinal spread of cultivation from south to north. However, methodological problems relating to pollen morphology of cereals, site characteristics and lack of connections to archaeologically excavated sites imply that the value of many early cereal pollen finds remains unclear. To increase our understanding of the context in which cereal cultivation was introduced in northernmost Fennoscandia, multidisciplinary studies integrating palaeoecology, archaeology and history are needed.</p>
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3.
  • Nordfors, Cecilia, et al. (författare)
  • Oral human papillomavirus prevalence in high school students of one municipality in Sweden
  • 2013
  • Ingår i: Scandinavian Journal of Infectious Diseases. - 0036-5548 .- 1651-1980. ; 45:11, s. 878-881
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The rise in human papillomavirus (HPV) infection has been suggested to be responsible for the increased incidence of oropharyngeal cancer in the Western world. This has boosted interest in oral HPV prevalence and whether HPV vaccines can prevent oral HPV infection. In a previous study we showed oral HPV prevalenceto be almost 10% in youth aged 15-23 y attending a youth clinic in Stockholm, Sweden. However, this may not be a generalizable sample within the Swedish population. Therefore, mouthwashes were used to investigate oral HPV prevalence in 335 Swedish high school students aged 17-21 y (median age 18 y), from 1municipality with 140,000 inhabitants. The presence of HPV DNA in the oral samples, as examined by a Luminex-based assay, was significantly lower in this cohort, only 1.8% (3.1% in females and 0.6% in males), as compared to our previous study.</p>
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4.
  • Näsman, Anders, et al. (författare)
  • Absent/weak CD44 intensity and positive human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma indicates a very high survival
  • 2013
  • Ingår i: Cancer Medicine. - John Wiley & Sons. - 2045-7634 .- 2045-7634. ; 2:4, s. 507-18
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Patients with human papillomavirus DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) have better clinical outcome than those with HPV DNA negative (HPVDNA-) OSCC upon intensive oncological treatment. All HPVDNA+ OSCC patients may not require intensive treatment, however, but before potentially deintensifying treatment, additional predictive markers are needed. Here, we examined HPV, p16(INK4a), and CD44 in OSCC in correlation to clinical outcome. Pretreatment tumors from 290 OSCC patients, the majority not receiving chemotherapy, were analyzed for HPV DNA by Luminex and for p16(INK4a) and CD44 by immunohistochemistry. 225/290 (78%) tumors were HPVDNA+ and 211/290 (73%) overexpressed p16(INK4a), which correlated to presence of HPV (P &lt; 0.0001). Presence of HPV DNA, absent/weak CD44 intensity staining correlated to favorable 3-year disease-free survival (DFS) and overall survival (OS) by univariate and multivariate analysis, and likewise for p16(INK4a) by univariate analysis. Upon stratification for HPV, HPVDNA+ OSCC with absent/weak CD44 intensity presented the significantly best 3-year DFS and OS, with &gt;95% 3-year DFS and OS. Furthermore, in HPVDNA+ OSCC, p16(INK4a)+ overexpression correlated to a favorable 3-year OS. In conclusion, patients with HPVDNA+ and absent/weak CD44 intensity OSCC presented the best survival and this marker combination could possibly be used for selecting patients for tailored deintensified treatment in prospective clinical trials. Absence of/weak CD44 or presence of human papillomavirus (HPV) DNA was shown as a favorable prognostic factors in tonsillar and tongue base cancer. Moreover, patients with the combination of absence of/weak CD44 and presence of HPV DNA presented a very favorable outcome. Therefore, we suggest that this marker combination could potentially be used to single out patients with a high survival that could benefit from a de-escalated oncological treatment.</p>
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