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Träfflista för sökning "WFRF:(Satoh Y.) srt2:(2010-2014)"

Sökning: WFRF:(Satoh Y.) > (2010-2014)

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2.
  • Popov, Sergej, et al. (författare)
  • Salt-inducible kinase 1 influences Na+,K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.
  • 2011
  • Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 1473-5598 .- 0263-6352. ; 29:12, s. 2395-2403
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential role in regulating the plasma membrane Na,K-ATPase. The objective of this study was to examine whether SIK1 is present in vascular smooth muscle cells (VSMCs) and endothelial cells, whether it affects VSMC Na,K-ATPase activity and whether human SIK1 (hSIK1) represents a potential candidate for blood pressure regulation. METHODS: Localization of SIK1 was performed using immunohistochemistry, mRNA and western blot. Functional assays (Na,K-ATPase activity) were performed in VSMCs derived from rat aorta. Genotype-phenotype association studies were performed in three Swedish and one Japanese population-based cohorts. RESULTS: SIK1 was localized in human VSMCs and endothelial cells, as well as a cell line derived from rat aorta. A nonsynonymous single nucleotide polymorphism in the hSIK1 gene exon 3 (C→T, rs3746951) results in the amino acid change Gly→Ser in the SIK1 protein. SIK1-Ser was found to increase plasma membrane Na,K-ATPase activity in cultured VSMC line from rat aorta. Genotype-phenotype association studies in three Swedish and one Japanese population-based cohorts suggested that T allele (coding for Ser) was associated with lower blood pressure (P = 0.005 for SBP and P = 0.002 for DBP) and with a decrease in left ventricular mass (P = 0.048). CONCLUSION: The hSIK1 appears to be of potential relevance within VSMC function and blood pressure regulation.
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4.
  • Satoh, Toyomi, et al. (författare)
  • Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix.
  • 2014
  • Ingår i: International Journal of Gynecological Cancer. - : Lippincott Williams & Wilkins. - 1048-891X .- 1525-1438. ; 24:9, s. S102-S108
  • Forskningsöversikt (refereegranskat)abstract
    • Small cell carcinoma of the cervix (SCCC) is a rare histological entity of uterine cervical cancer. Compared with other common histological types, squamous cell carcinoma or adenocarcinoma, the outcome of SCCC is poor because of the high incidence of nodal or distant metastasis even with early stage. In this review, current consensus of epidemiology, pathology, and initial treatment for SCCC will be discussed.
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5.
  • Makoto, Kobayashi, et al. (författare)
  • Contribution of charcoal to short-term nutrient dynamics after surface fire in the humus layer of a dwarf bamboo-dominated forest
  • 2012
  • Ingår i: Biology and Fertility of Soils. - 0178-2762 .- 1432-0789. ; 48:5, s. 569-577
  • Tidskriftsartikel (refereegranskat)abstract
    • Ecological function of charcoal has been mainly investigated by adding charcoal to soil, which is not fully adequate to understand in situ the role in fire-prone forest ecosystem. To determine in situ effects of charcoal on ecosystem functions, such as nutrient availability, we conducted an experimental burning in a Japanese white birch forest with dense coverage of dwarf bamboo in the understory with or without removal of charcoal. Ammonium-N in the remaining humus layer increased immediately after the burning, but decreased to the level of unburnt plots within 1 month of the burning. Removal of charcoal had no significant effect on the NH4 (+)-N dynamics. Although burning did not affect NO3 (-)-N dynamics during the sampling period, charcoal removal led to a slight increase in NO3 (-)-N. The available P increased immediately after the burning, but then fell at 1 month after burning. Charcoal inhibited the available P depletion and prolonged the high availability of P. Greater availability of P might be due to the adsorption of phosphate in charcoal pores. Exchangeable Ca and Mg increased gradually; charcoal appeared to extend the period of higher concentration of exchangeable Ca and Mg. Charcoal deriving from fire is a key factor in influencing available nutrient in the humus layer of post-fire forests.
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  • Resultat 1-5 av 5

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