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1.
  • af Klinteberg, C, et al. (författare)
  • Laser-induced fluorescence diagnostics of basal cell carcinomas of the skin following topical ALA application
  • 1996
  • Ingår i: Optical Biopsies and Microscopic Techniques, Proceedings of. - The Society of Photo-optical Instrumentation Engineers (SPIE). - 0-8194-2328-9 ; 2926, s. 32-40
  • Konferensbidrag (refereegranskat)abstract
    • Fourteen patients with superficial basal cell carcinomas (BCCs) and fifteen patients with nodular BCCs were investigated by means of laser-induced fluorescence (LIF) in connection with photodynamic therapy (PDT). Topical application of delta-amino levulinic acid (ALA) was performed six hours prior to the treatment session. Fluorescence spectra were recorded, using a point-monitoring system with an excitation wavelength of 405 nm. The measurements were performed in scans over the lesion and the surrounding normal skin before application of ALA, and immediately before and after the laser treatment. The selective uptake of the photosensitiser resulted in a fluorescence intensity ratio of 2.4:1 for superficial BCCs and 2.5:1 for nodular BCCs. If the fluorescence intensity was divided by the autofluorescence, this resulted in a contrast enhancement of about a factor 6 for tumour tissue. In seven patients (five with nodular BCC and two with superficial BCC), additional fluorescence measurements were performed two and four hours following the ALA application, and two hours after the PDT procedure. Thus, the kinetics of the transformation of ACA to protoporphyrin IX (PpIX) could be followed, which indicated that the synthesis of PpIX was more rapid in the tumour than in the normal tissue. After four hours, the PpIX level inside the tumour was saturated, while there still was an accumulation in the surrounding skin. The highest contrast between tumour and normal skin was reached within two hours after the ALA application.
2.
  • Andersson-Engels, Stefan, et al. (författare)
  • Aspects of Tumour Demarcation In Rats By Means of Laser-induced Fluorescence and Hematoporphyrin Derivatives
  • 1988
  • Ingår i: Lasers in Medical Science. - 0268-8921. ; 3:4, s. 239-248
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporophyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the tumor tumour-seeking agents Photofrin (haematoporphyrin deriative) and Photofrin II (dihaematoporphyrin ether) we have performed a comparative study on rat tissues. The results suggest that Photofrin is at least as good as the therapeutically more potent agent Photofrin II. A linear relation between drug dose and recorded prophyrin fluorescence intensity was also found. Using not only the porphyrin fluorescence, but also natural tissue autofluorescence, better tumour demarcation is observed when utilizing an excitation wavelength shorter than the porphyrin excitation peak at 405 nm.
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3.
  • Andersson-Engels, Stefan, et al. (författare)
  • Autofluorescence of various rodent tissues and human skin tumour samples
  • 1987
  • Ingår i: Lasers in Medical Science. - Springer London. - 0268-8921. ; 2:1, s. 41-49
  • Tidskriftsartikel (refereegranskat)abstract
    • Fluorescence spectra from different organs in rats and mice have been recorded to explore the potential of non-intrusive tissue diagnostics. The fluorescence was induced by a nitrogen laser that emitted at a wavelength of 337 nm. Optical multichannel techniques were used for the detection. Spectra are given from 19 different sites in Wistar/Furth rats, including an inoculated malignant tumour. The spectra seem to be a sum of two wavelength distributions only, each distribution occurring with a different weight in different organs. Spectra obtained from living and dead tissue were compared to verify that the measurements on sacrificed experimental animals were valid. Preliminary results are given for some human tumours, transplanted in nude mice, and for some human skin samples.
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7.
  • Berg, R, et al. (författare)
  • Time-gated viewing studies on tissue -like phantoms
  • 1994
  • Ingår i: PROCEEDINGS OF OPTICAL BIOPSY. - The Society of Photo-optical Instrumentation Engineers (SPIE). - 0-8194-1348-8 ; 2081, s. 137-146
  • Konferensbidrag (refereegranskat)
8.
  • Berg, Roger, et al. (författare)
  • Time-resolved tranillumination imaging
  • 1993
  • Ingår i: Medical Optical Tomography: Functional Imaging and Monitoring. - SPIE Optical Engineering Press, Bellingham, USA. - 978081941379 ; s. 397-424
  • Bokkapitel (refereegranskat)
  •  
9.
  • Eker, C, et al. (författare)
  • Clinical spectral characterisation of colonic mucosal lesions using autofluorescence and delta aminolevulinic acid sensitisation
  • 1999
  • Ingår i: Gut. - 0017-5749. ; 44:4, s. 511-518
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and aims-Laser induced fluorescence (LIF) from colonic mucosa was measured in vivo with and without delta aminolevulinic acid (ALA) in an attempt to differentiate between neoplasia and non-neoplasia in real time during colonoscopy. Methods-Spectra from 32 adenomas, 68 normal sites, and 14 hyperplastic polyps in 41 patients were obtained with a point monitoring system. Twenty one of the patients had been given a low dose of ALA as a photosensitiser before the examination. Light of 337, 405, or 436 nm wavelength was used as excitation. Stepwise multivariate Linear regression analysis was performed. Results-With 337 nm excitation, 100% sensitivity and 96% specificity was obtained between normal mucosa and adenomas. Seventy seven per cent of the hyperplastic polyps were classified as non-neoplastic. When exciting with 405 and 436 nm, the possibility of distinguishing different types of tissue was considerably better in the ALA patients than in the non-ALA patients. Conclusions-The in vivo point measurements imply that a good discrimination between normal tissue and adenomatous polyps can be obtained using the LIF technique. Excitation at 337 nm and at 405 nm or 436 nm using ALA gives good results. LIF also shows potential for distinguishing adenomatous from hyperplastic polyps. The number of detection wavelengths could be reduced if chosen properly.
10.
  • Lundin, Patrik, et al. (författare)
  • Gas Monitoring in Human Body Cavities Using Non-Intrusive Diode Laser Absorption Spectroscopy
  • 2012
  • Ingår i: 2012 Asia Communications and Photonics Conference. - Optical Society of America. - 2162-108X. ; s. AS4E.7
  • Konferensbidrag (refereegranskat)abstract
    • Diode laser absorption spectroscopy was utilized for non-intrusive assessment of gas content in human body cavities, including intestines and lungs of a new-born, the mastoid bone, and sinus cavities for monitoring sinusitis recovery in adults.
  •  
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