SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wetzel K.) srt2:(2015-2019)"

Sökning: WFRF:(Wetzel K.) > (2015-2019)

  • Resultat 1-7 av 7
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  • Schofield, James P. R., et al. (författare)
  • Stratification of asthma phenotypes by airway proteomic signatures
  • 2019
  • Ingår i: Journal of Allergy and Clinical Immunology. - Elsevier. - 0091-6749 .- 1097-6825. ; 144:1, s. 70-82
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Stratification by eosinophil and neutrophil counts increases our understanding of asthma and helps target therapy, but there is room for improvement in our accuracy in prediction of treatment responses and a need for better understanding of the underlying mechanisms.</p><p>Objective: We sought to identify molecular subphenotypes of asthma defined by proteomic signatures for improved stratification.</p><p>Methods: Unbiased label-free quantitative mass spectrometry and topological data analysis were used to analyze the proteomes of sputum supernatants from 246 participants (206 asthmatic patients) as a novel means of asthma stratification. Microarray analysis of sputum cells provided transcriptomics data additionally to inform on underlying mechanisms.</p><p>Results: Analysis of the sputum proteome resulted in 10 clusters (ie, proteotypes) based on similarity in proteomic features, representing discrete molecular subphenotypes of asthma. Overlaying granulocyte counts onto the 10 clusters as metadata further defined 3 of these as highly eosinophilic, 3 as highly neutrophilic, and 2 as highly atopic with relatively low granulocytic inflammation. For each of these 3 phenotypes, logistic regression analysisidentified candidate protein biomarkers, and matched transcriptomic data pointed to differentially activated underlying mechanisms.</p><p>Conclusion: This study provides further stratification of asthma currently classified based on quantification of granulocytic inflammation and provided additional insight into their underlying mechanisms, which could become targets for novel therapies.</p>
  •  
5.
  • Dicke, B., et al. (författare)
  • Transferring the entatic-state principle to copper photochemistry
  • 2018
  • Ingår i: Nature Chemistry. - 1755-4349 .- 1755-4330. ; 10:3, s. 355-362
  • Tidskriftsartikel (refereegranskat)abstract
    • The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a multitude of biochemical processes, but its importance to photoactive complexes is unexplored. Here we study a copper complex-with a specifically designed constraining ligand geometry-that exhibits metal-to-ligand charge-transfer state lifetimes that are very short. The guanidine-quinoline ligand used here acts on the bis(chelated) copper(I) centre, allowing only small structural changes after photoexcitation that result in very fast structural dynamics. The data were collected using a multimethod approach that featured time-resolved ultraviolet-visible, infrared and X-ray absorption and optical emission spectroscopy. Through supporting density functional calculations, we deliver a detailed picture of the structural dynamics in the picosecond-to-nanosecond time range.
  •  
6.
  • Dicke, B., et al. (författare)
  • Transferring the entatic-state principle to copper photochemistry
  • 2018
  • Ingår i: Nature Chemistry. - NATURE PUBLISHING GROUP. - 1755-4330 .- 1755-4349. ; 10:3, s. 355-362
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a multitude of biochemical processes, but its importance to photoactive complexes is unexplored. Here we study a copper complex-with a specifically designed constraining ligand geometry-that exhibits metal-to-ligand charge-transfer state lifetimes that are very short. The guanidine-quinoline ligand used here acts on the bis(chelated) copper(I) centre, allowing only small structural changes after photoexcitation that result in very fast structural dynamics. The data were collected using a multimethod approach that featured time-resolved ultraviolet-visible, infrared and X-ray absorption and optical emission spectroscopy. Through supporting density functional calculations, we deliver a detailed picture of the structural dynamics in the picosecond-to-nanosecond time range.</p>
  •  
7.
  • Martinsson, Svante, 1985-, et al. (författare)
  • DNA-barcoding of invasive European earthworms (Clitellata: Lumbricidae) in south-western Australia
  • 2015
  • Ingår i: Biological Invasions. - 1387-3547. ; 17:9, s. 2527-2532
  • Tidskriftsartikel (refereegranskat)abstract
    • Using DNA-barcoding, we studied the diversity of invasive European earthworms in the south-western corner of Australia. We found six Molecular Operational Taxonomic Units belonging to five morphospecies: Aporrectodea caliginosa, A. trapezoides, Dendrobaena cf. attemsi, Eiseniella tetraedra and Octolasion cyaneum. These were variously collected from indigenous forests and/or alienated land. Two cryptic lineages were found within A. trapezoides, and high intraspecific genetic variation was also found within E. tetraedra-variation that had previously been documented in Europe. Our study demonstrates the usefulness of DNA-barcoding for the identification of earthworms, including cryptic species. Correct identification and high taxonomic resolution is crucial for the monitoring of cryptic diversity, detecting new introductions and monitoring spread of established exotic earthworms.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-7 av 7
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy