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Träfflista för sökning "WFRF:(Willén Roger) srt2:(2015-2016)"

Sökning: WFRF:(Willén Roger) > (2015-2016)

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1.
  • Rangel, Ignacio, et al. (författare)
  • Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of G alpha i2-deficient mice
  • 2016
  • Ingår i: Fems Microbiology Ecology. - 0168-6496. ; 92:7
  • Tidskriftsartikel (refereegranskat)abstract
    • An altered immune response and gut microbiota have been associated with the pathology of inflammatory bowel diseases (IBDs). However, there is limited knowledge of how inflammation is associated with changes in the microbiota. We studied the microbiota in the intestine and faeces as well as the cytokine gene expressions in caecum and colon of a mouse model (G alpha i2(-/-)) of colitis, and analysed them in relation to the degrees of inflammation in the colon. The degree of colitis was associated with general changes in the complexity of the microbiota and was corroborated by quantitative analyses of the Bacteroides and Lactobacillus. High gene expression levels of IL-17 and IFN-gamma in colon and caecum were detected in G alpha i2(-/-) mice with moderate and severe colitis. High IL-27 gene expression in the colon of mice with moderate and severe colitis and in the caecum of mice with moderate colitis was also detected. Negative correlations between IL-27 and Bacteroides and Lactobacillus and between IFN-gamma and Lactobacillus were detected in caecum. This research indicates that the degree of colitis in IBD correlates with the gene expression of cytokines and with disturbances in the gut microbiota. Furthermore, the caecum could have an important role in the pathology of IBD.
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2.
  • Bergström, Staffan, et al. (författare)
  • Utred självvalt livsslut
  • 2016
  • Ingår i: Läkartidningen. - Swedish Medical Association. - 0023-7205. ; 113:34-35
  • Tidskriftsartikel (övrigt vetenskapligt)
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3.
  • Block, Mattias, 1968-, et al. (författare)
  • Neoplasia in the colorectal specimens of patients with ulcerative colitis and ileal pouch-anal anastomosis - need for routine surveillance?
  • 2015
  • Ingår i: Scandinavian journal of gastroenterology. - 1502-7708. ; 50:5, s. 528-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Patients who undergo ileal pouch-anal anastomosis (IPAA) after colectomy for ulcerative colitis (UC) occasionally have neoplasia in the IPAA. Patients with evidence of dysplasia or carcinoma in the colorectal specimen may have an increased risk of such neoplasia. A surveillance program has been suggested. The aims of this study were to evaluate the outcomes of surveillance of a large patient cohort, and to investigate the prevalences of neoplasia in the ileal pouch mucosa and in the anal transitional zone (ATZ).
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4.
  • Rangel, Ignacio, 1969-, et al. (författare)
  • Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice
  • 2016
  • Ingår i: FEMS Microbiology Ecology. - Oxford, United Kingdom : Oxford University Press. - 0168-6496. ; 92:7
  • Tidskriftsartikel (refereegranskat)abstract
    • An altered immune response and gut microbiota have been associated with the pathology of Inflammatory Bowel Diseases (IBD). However, there is limited knowledge of how inflammation is associated with changes in the microbiota. We studied the microbiota in the intestine and faeces as well as the cytokine gene expressions in caecum and colon of a mouse model (Gαi2(-/-)) of colitis, and analysed them in relation to the degrees of inflammation in the colon. The degree of colitis was associated with general changes in the complexity of the microbiota and was corroborated by quantitative analyses of the Bacteroides and Lactobacillus High gene expression levels of IL-17 and IFN-γ in colon and caecum were detected in Gαi2(-/-) mice with moderate and severe colitis. High IL-27 gene expression in the colon of mice with moderate and severe colitis and in the caecum of mice with moderate colitis was also detected. Negative correlations between IL-27 and Bacteroides and Lactobacillus and between IFN-γ and Lactobacillus were detected in caecum. This research indicates that the degree of colitis in IBD correlates with the gene expression of cytokines and with disturbances in the gut microbiota. Furthermore, the caecum could have an important role in the pathology of IBD.
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  • Resultat 1-4 av 4
 
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