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Sökning: WFRF:(Wolf Eva)

  • Resultat 1-10 av 29
  • [1]23Nästa
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  • Ad, Niv, et al. (författare)
  • Surgical Ablation for Atrial Fibrillation in Cardiac Surgery. A Consensus Statement of the international Society of Minimally Invasive Cardiothoracic Surgery (ISMICS)
  • 2010
  • Ingår i: Innovations. - 1556-9845. ; 5:2, s. 74-83
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: This purpose of this consensus conference was to determine whether surgical atrial fibrillation (AF) ablation during cardiac surgery improves clinical and resource outcomes compared with cardiac surgery alone in adults undergoing cardiac surgery for valve or coronary artery bypass grafting. Methods: Before the consensus conference, the consensus panel reviewed the best available evidence, whereby systematic reviews, randomized trials, and nonrandomized trials were considered in descending order of validity and importance. Evidence-based statements were created, and consensus processes were used to determine the ensuing recommendations. The American Heart Association/American College of Cardiology system was used to label the level of evidence and class of recommendation. Results: The consensus panel agreed on the following statements in patients with AF undergoing cardiac surgery concomitant surgical ablation: 1. Improves the achievement of sinus rhythm at discharge and 1 year (level A); this effect is sustained up to 5 years (level B). Does not reduce the use of antiarrhythmic drugs at 12 months after surgery (level A; 36.0% vs. 45.4%), although trials were not designed to answer this question. 2. Does not increase the requirement for permanent pacemaker implantation (4.4% vs. 4.8%; level A). 3. Does not increase the risk of perioperative mortality (level A), stroke (level A), myocardial infarction (level B), cardiac tamponade (level A), reoperative bleeding (level A), esophageal injury (level B), low cardiac output (level A), intraaortic balloon (level B), congestive heart failure (level B), ejection fraction (EF; level B), pleural effusion (level A), pneumonia (level A), renal dysfunction (level B), and mediastinitis (level A). The incidence of esophageal injury remains to be low (level B). 4. Does not reduce mortality at 1 year (level A). There is a possible reduction in mortality beyond 1 year (level B), but no difference in stroke (level A), myocardial infarction (level A), and heart failure (level B). EF is increased (+4.1% more than control; level A). 5. Has been shown to improve exercise tolerance at 1 year (level A), but no impact on quality of life at 3 months and 1 year (level A); however, the methodology used and the number of trials studying these outcomes are insufficient. 6. Increases cardiopulmonary bypass and cross-clamp times (level A), with no difference in intensive care unit and hospital length of stay (level A). Overall costs were not reported. Conclusions: Given these evidence-based statements, the consensus panel stated that, in patients with persistent and permanent AF undergoing cardiac surgery, concomitant surgical ablation is recommended to increase incidence of sinus rhythm at short- and long-term follow-up (class 1, level A); to reduce the risk of stroke and thromboembolic events (class 2a, level B); to improve EF (class 2a, level A); and to exercise tolerance (class 2a, level A) and long-term survival (class 2a, level B).
  • Allemani, Claudia, et al. (författare)
  • Breast cancer survival in the US and Europe: a CONCORD high-resolution study
  • 2013
  • Ingår i: International Journal of Cancer. - Wiley-Blackwell Publishing. - 0020-7136. ; 132:5, s. 1170-1181
  • Tidskriftsartikel (refereegranskat)abstract
    • Breast cancer survival is reportedly higher in the US than in Europe. The first worldwide study (CONCORD) found wide international differences in age-standardized survival. The aim of this study is to explain these survival differences. Population-based data on stage at diagnosis, diagnostic procedures, treatment and follow-up were collected for about 20,000 women diagnosed with breast cancer aged 15-99 years during 1996-98 in 7 US states and 12 European countries. Age-standardized net survival and the excess hazard of death up to 5 years after diagnosis were estimated by jurisdiction (registry, country, European region), age and stage with flexible parametric models. Breast cancers were generally less advanced in the US than in Europe. Stage also varied less between US states than between European jurisdictions. Early, node-negative tumors were more frequent in the US (39%) than in Europe (32%), while locally advanced tumors were twice as frequent in Europe (8%), and metastatic tumors of similar frequency (5-6%). Net survival in Northern, Western and Southern Europe (81-84%) was similar to that in the US (84%), but lower in Eastern Europe (69%). For the first 3 years after diagnosis the mean excess hazard was higher in Eastern Europe than elsewhere: the difference was most marked for women aged 70-99 years, and mainly confined to women with locally advanced or metastatic tumors. Differences in breast cancer survival between Europe and the US in the late 1990s were mainly explained by lower survival in Eastern Europe, where low healthcare expenditure may have constrained the quality of treatment.
  • Bondemark, Lars, et al. (författare)
  • Funktionsstörningar och smärta
  • 2008
  • Ingår i: Tandläkartidningen;9-10. - 0039-6982. ; :9-10
  • Tidskriftsartikel (populärvet., debatt m.m.)
  • Eva, Wolf, et al. (författare)
  • Lyssnande möten i tandvården
  • 2012
  • Ingår i: Hälsofrämjande möten : från barnhälsovård till palliativ vård. - Studentlitteratur. - 9789144070452
  • Bokkapitel (övrigt vetenskapligt)
  • Fransson, Helena, et al. (författare)
  • Efficacy of lasers as an adjunct to chemo-mechanical disinfection of infected root canals: a systematic review.
  • 2013
  • Ingår i: International Endodontic Journal;4. - Wiley-Blackwell. - 0143-2885. ; :4
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim was to evaluate the efficacy of various types of lasers used as an adjunct to chemo-mechanical disinfection of infected root canals with the outcome measures 'normal periapical condition' or 'reduction of microbial load'. PubMed, CENTRAL and ISI Web of Knowledge literature searches with specific indexing terms and a subsequent hand search were made with stated limits and criteria. Relevant publications were retrieved, followed by interpretation. The quality of each included publication was assessed as high, moderate or low. The initial search process yielded 234 publications. All abstracts of these publications were read, and the reference lists of relevant publications were hand-searched. Ten articles were read in full text and interpreted according to a data extraction form. Five were included in the systematic review and were assessed. A meta-analysis was impossible to perform because the included studies were heterogeneous with regard to study design, treatment and outcome measures. Positive effects were reported; however, no concluding evidence grade could be made because each included study was judged to have low quality, primarily due to lack of a power analysis, blinding and reproducibility. The evidence grade for whether lasers can be recommended as an adjunct to chemo-mechanical disinfection of infected root canals was insufficient. This does not necessarily imply that laser should not be used as an adjunct to root canal treatment but instead underscores the need for future high-quality studies.
  • Koch, Margaretha, et al. (författare)
  • Successful clinical and organisational change in endodontic practice : a qualitative study
  • 2013
  • Ingår i: European Journal of Dental Education. - Wiley. - 1396-5883.
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to explicate and describe the qualitative meaning of successful clinical and organizational change in endodontic practice, following a comprehensive implementation program, including the integration of the nickel-titanium-rotary-technique. After an educational intervention in the Public Dental Service in a Swedish county, thematic in-depth interviews were conducted, with special reference to the participants' experience of the successful change. Interviews with four participants, were purposively selected on the basis of occupation (dentist, dental assistant, receptionist, clinical manager), for a phenomenological human scientific analysis. Four constituents were identified as necessary for the invariant, general structure of the phenomenon: 1) disclosed motivation, 2) allowance for individual learning processes, 3) continuous professional collaboration, and 4) a facilitating educator. The perceived requirements for achieving successful clinical and organizational change in endodontic practice were clinical relevance, an atmosphere which facilitated discussion and allowance for individual learning patterns. The qualities required in the educator were acknowledged competence with respect to scientific knowledge and clinical expertise, as well as familiarity with conditions at the dental clinics. The results indicate a complex interelationship among various aspects of the successful change process.
  • Nikolić, Dragan, et al. (författare)
  • Dielectronic recombination resonances in Na8
  • 2004
  • Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - The American Physical Society. - 1050-2947. ; 70:6
  • Tidskriftsartikel (refereegranskat)abstract
    • The electron-ion recombination spectrum of the Li-like Na8+ ion in the energy range 0.0–0.5 eV is presented. Experimental results obtained by storage-ring techniques are compared with a calculated spectrum, based on a combination of relativistic many-body methods and complex rotation, and the agreement is found to be very good. The deviations between measured and calculated dielectronic recombination resonance energies are usually below about 2 meV with a maximum difference at 5.5 meV, while the theoretical cross sections deviate by at most 20% from the experiment. The recombination spectrum in the investigated energy region is determined by the 2pj7ℓj′ Rydberg manifold of dielectronic recombination resonances, comprising 61 states within half an eV above the ground state of Na8+. The theoretical resonance parameters of all contributing states are provided.
  • Pettersson, Jonas, et al. (författare)
  • The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation :  
  • 1999
  • Ingår i: Molecular Microbiology. - John Wiley & Sons. - 0950-382X. ; 32:5, s. 961-976
  • Tidskriftsartikel (refereegranskat)abstract
    • Type III-mediated translocation of Yop effectors is an essential virulence mechanism of pathogenic Yersinia. LcrV is the only protein secreted by the type III secretion system that induces protective immunity. LcrV also plays a significant role in the regulation of Yop expression and secretion. The role of LcrV in the virulence process has, however, remained elusive on account of its pleiotropic effects. Here, we show that anti-LcrV antibodies can block the delivery of Yop effectors into the target cell cytosol. This argues strongly for a critical role of LcrV in the Yop translocation process. Additional evidence supporting this role was obtained by genetic analysis. LcrV was found to be present on the bacterial surface before the establishment of bacteria target cell contact. These findings suggest that LcrV serves an important role in the initiation of the translocation process and provides one possible explanation for the mechanism of LcrV-induced protective immunity.
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