SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Yang Rui) "

Sökning: WFRF:(Yang Rui)

  • Resultat 1-10 av 34
  • [1]234Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hu, Qing-Miao, et al. (författare)
  • Composition dependent elastic modulus and phase stability of Ni2MnGa based ferromagnetic shape memory alloys
  • 2012
  • Ingår i: SCI CHINA TECHNOL SC. - 1674-7321. ; 55:2, s. 295-305
  • Tidskriftsartikel (refereegranskat)abstract
    • Ni2MnGa based ferromagnetic alloys are ideal candidates for applications such as actuators, magnetic refrigerators or magnetostrictive transducers due to their attractive properties such as magnetic field induced shape memory effect and large magnetocaloric effect. The properties of these alloys (e.g., the martensitic transformation temperature T (M) ) sensitively depend on the composition. Understanding the composition dependence of these properties so as to design the alloy as desired is one of the main research topics in this area. In recent years, we have investigated the composition dependent elastic modulus and phase stability of Ni2MnGa-based alloys by using a first-principles method, in hope of clarifying their connection to the properties of these alloys. In this article, we review the main results of our investigations. We show that the tetragonal shear modulus C' is a better predictor of the composition dependent T (M) than the number of valence electrons per atom (e/a) since the general T (M) similar to C' correlation works for some of the alloys for which the T (M) similar to e/a correlation fails, although there exist several cases for which both the general T (M) similar to C' and T (M)similar to e/a correlations break down. Employing the experimentally determined modulation function, the complex 5-layer modulated (5M) structure of the martensite of Ni2MnGa and the Al-doping effect on it are studied. We find that the shuffle and shear of the 5M structure are linearly coupled. The relative stability of the austenite and the martensites is examined by comparing their total energies. The non-modulated martensite beta aEuro(3)aEuro(2) with the tetragonality of the unit cell c/a > 1 is shown to be globally stable whereas the 5M martensite with c/a < 1 is metastable. The critical Al atomic fraction over which the martensitic transformation between the 5M martensite and austenite cannot occur is predicted to be 0.26, in reasonable agreement with experimental findings.
  •  
2.
  • Shi, Leming, et al. (författare)
  • The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
  • 2010
  • Ingår i: Nature Biotechnology. - 1087-0156. ; 28:8, s. 827-838
  • Tidskriftsartikel (refereegranskat)abstract
    • Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.
  •  
3.
  • Wang, Mojin, et al. (författare)
  • A-Kinase Anchoring Proteins 10 Expression in Relation to 2073A/G Polymorphism and Tumor Progression in Patients with Colorectal Cancer
  • 2013
  • Ingår i: Pathology and Oncology Research. - Springer Verlag (Germany). - 1219-4956. ; 19:3, s. 521-527
  • Tidskriftsartikel (refereegranskat)abstract
    • The cAMP/PKA signalling events regulated by A-kinase anchoring proteins 10 (AKAP10) is involved in tumorigenesis. Previous study showed that AKAP10 polymorphism (2073 A/G, I646V) was associated with colorectal cancer risk. However, there was no literature reporting the role of AKAP10 in the pathogenesis of colorectal cancer. The aim of the study was to investigate the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer. The expression of AKAP10 was determined by immunohistochemical staining (IHC) and western blot assay on colorectal cancer (n = 176), adenoma (n = 87) and distant normal mucosa (n  = 72). 176 patients with colorectal cancer were genotyped for AKAP10 2073A/G polymorphism by TaqMan RT-PCR. We found that the positive expression rate of AKAP10 in colorectal cancer (59 %) was significantly higher than those in adenoma (39 %) and distant normal mucosa (42 %) (P = 0.004). There was no significant difference between adenoma and distant normal mucosa (P = 0.741). Positive AKAP10 staining was correlated with deeper tumor invasion (P < 0.001), lymph nodes metastasis (P = 0.022), advanced tumor stage (P < 0.001) and poorly differentiated degree (P  = 0.003). Compared with AA genotype (52 %), positive expression of AKAP10 was significantly increased in colorectal cancer patients with the variant (AG+GG) genotypes (68 %, P = 0.033). It was concluded that AKAP10 may play an important role in the development and progression of colorectal cancer.
4.
  • Wang, Mo-Jin, et al. (författare)
  • Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer
  • 2013
  • Ingår i: International Journal of Colorectal Disease. - Springer Verlag (Germany). - 0179-1958. ; 28:2, s. 183-189
  • Tidskriftsartikel (refereegranskat)abstract
    • PurposeRecently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal cancer.MethodsQuantitative real-time PCR was used to analyze miR-124 expression in 96 colorectal cancers and individual-matched normal mucosa samples. The expression of miR-124 was assessed for associations with clinicopathological characteristics using chi-square test. The survival curves were calculated by the Kaplan–Meier method. The influence of each variable on survival was examined by the Cox multivariate regression analysis.ResultsThe miR-124 expression was significantly downregulated in colorectal cancer compared to normal mucosa (P = 0.001). In colorectal cancer, miR-124 decreased expression correlated significantly with the grade of differentiation (P  = 0.021). Univariate survival analysis showed that the downregulated miR-124 was significantly correlated with worse prognosis, both in terms of overall survival (P = 0.017) and disease-free survival (DFS) (P  = 0.014). Further, the downregulated miR-124 was demonstrated as a prognostic factor for overall survival (hazard ratio, HR = 4.634; 95 % confidence interval, CI, 1.731–12.404; P = 0.002) and DFS (HR = 4.533, 95 % CI 1.733–11.856, P = 0.002), independently of gender, age, location, maximum tumor size, depth of invasion, differentiation, and TNM stage.ConclusionsMiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer.
5.
  • Cao, Yang, et al. (författare)
  • Validation of a survey methodology for gastroesophageal reflux disease in China
  • 2008
  • Ingår i: BMC Gastroenterology. - 1471-230X. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUNDGastroesophageal reflux disease (GERD) causes a wide range of clinical symptoms and potentially serious complications, but epidemiological data about GERD in China are limited. The aim of this pilot study was to develop and validate a methodology for the epidemiological study of GERD in China.METHODSRegionally stratified, randomized samples of Shanghai residents (n = 919) completed Mandarin translations of the Reflux Disease Questionnaire (RDQ), GERD Impact Scale, Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire and 36-item Short Form Health Survey (SF-36). Reliability and construct validity were tested by appropriate statistical analyses.RESULTSThe response rate was 86%. The test-retest reliability coefficients for the RDQ, GERD Impact Scale, QOLRAD and SF-36 were 0.80, 0.71, 0.93 and 0.96, respectively, and Cronbach's alpha coefficients were 0.86, 0.80, 0.98 and 0.90, respectively. Dimension scores were highly correlated with the total scores for the QOLRAD and SF-36, and factor analysis showed credible construct validity for the RDQ, GERD Impact Scale and SF-36. The RDQ GERD score was significantly negatively correlated with QOLRAD dimensions of food and drink problems and social functioning, and was significantly negatively correlated with all dimensions of the SF-36. All eight of the SF-36 dimensions were significantly correlated with the QOLRAD total score.CONCLUSIONThis study developed and tested a successful survey methodology for the investigation of GERD in China. The questionnaires used demonstrated credible reliability and construct validity, supporting their use in larger epidemiological surveys of GERD in China.
  •  
6.
  • Chen, D., et al. (författare)
  • GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation
  • 2014
  • Ingår i: Biochimica et Biophysica Acta. Molecular Cell Research. - 0167-4889. ; 1843:2, s. 454-463
  • Tidskriftsartikel (refereegranskat)abstract
    • Angiotensin II (Ang II)-elicited excessive proliferation, hypertrophy and migration of vascular smooth muscle cells (VSMCs) are vital to the pathogenesis of atheroclerosis. Glutathione S-transferase pi (GSTpi) exists extensively in various kinds of cells and protects cells against different stresses. However, knowledge remains limited about what GSTpi acts in VSMCs. We investigated the effect of GSTpi on Ang II-induced VSMC proliferation, hypertrophy and migration and its latent mechanism. Overexpression and RNAi experiments demonstrated that GSTpi inhibited Ang II-induced proliferation, hypertrophy and migration of VSMCs and arrested progression of cell cycle from G0/G1 to S phase. Immunoprecipitation, mass spectrometry and confocal microscopy analyses showed that GSTpi directly associated with signal transducer and activator of transcription 3 (STAT3) to prevent Ang II-triggered binding of Src to STAT3 and thus suppressed Ang II-stimulated phosphorylation and nuclear translocation of STAT3, as well as cyclin D1 expression. In contrast, GSTpi didn't affect Ang II-activated extracellular signal-regulated kinase (ERK1/2). GSTpi acts as a negative regulator to prevent Ang II-triggered proliferative signaling in VSMCs, suggesting that it may protect vessels against the stresses associated with atherosclerosis formation.
  •  
7.
  •  
8.
  • Hu, Qing-Miao, et al. (författare)
  • Hardness and elastic properties of covalent/ionic solid solutions from first-principles theory
  • 2008
  • Ingår i: Journal of Applied Physics. - 0021-8979. ; 103:8, s. 083505
  • Tidskriftsartikel (refereegranskat)abstract
    • Most of the engineering materials are alloys (solid solutions) and inevitably contain some impurities or defects such as vacancies. However, theoretical predictions of the hardness of this kind of materials have rarely been addressed in literature. In this paper, a hardness formula for multicomponent covalent solid solution is proposed based on the work of Simunek and Vackar [Phys. Rev. Lett. 96, 085501 (2006)]. With this formula, the composition dependence of the hardness is investigated for titanium nitrogencarbide (TiN1-xCx), off-stoichiometric transition-metal nitrides (TiN1-x and VN1-x), and B-doped semiconductors. The predicted hardness is in good agreement with experiments. To investigate the most frequently quoted correlation between hardness and elastic modulus, the elastic moduli of the systems involved in this paper have also been calculated. The results show that the elastic moduli cannot be used for rigorous predictions of the hardness of the solid solutions.
  •  
9.
  • Hu, Qing-Miao, et al. (författare)
  • Magnetoelastic effects in Ni2Mn1+xGa1-x alloys from first-principles calculations
  • 2010
  • Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121. ; 81:6, s. 064108-1-064108-5
  • Tidskriftsartikel (refereegranskat)abstract
    • The magnetic coupling between Mn atoms on Ga sublattice (Mn-Ga) and Mn atoms on Mn sublattice (Mn-Mn) in Ni2Mn1+xGa1-x alloy and its effect on the elastic modulus of the alloy are investigated by the use of first-principles methods. It is shown that, for x = 0.25, the state with antiparallel Mn-Ga-Mn-Mn magnetic coupling is slightly more stable than that with parallel coupling, whereas for x = 0.10, both magnetic states are almost degenerated. For both antiparallel and parallel Mn-Ga-Mn-Mn magnetic couplings, the bulk modulus (B) of Ni2Mn1+xGa1-x deviates from the general e/a-B relationship with e/a being the number of valence electrons per atom. The shear modulus C' versus the martensitic transformation temperature T-M for Ni2Mn1+xGa1-x with antiparallel Mn-Ga-Mn-Mn magnetic coupling is in line with the general C'-T-M relationship for Ni2MnGa-based alloys, in contrast to the case of parallel Mn-Ga-Mn-Mn magnetic coupling.
  •  
10.
  • Hu, Qing-Miao, et al. (författare)
  • Site occupancy, magnetic moments, and elastic constants of off-stoichiometric Ni2MnGa from first-principles calculations
  • 2009
  • Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121. ; 79:14
  • Tidskriftsartikel (refereegranskat)abstract
    • The site occupancy and elastic modulus of off-stoichiometric Ni2MnGa alloys are investigated by the use of the first-principles exact muffin-tin orbital method in combination with coherent-potential approximation. The stable site occupancy at 300 K is determined by comparing the free energies of the alloys with different site-occupation configurations. It is shown that, for most of the off-stoichiometric Ni2MnGa, the "normal" site occupation is favorable, i.e., the excess atoms of the rich component occupy the sublattice(s) of the deficient one(s). Nevertheless, for the Ga-rich alloys, the excess Ga atoms have strong tendency to take the Mn sublattice no matter if Mn is deficient or not. Based on the determined site occupancy, the elastic moduli of the off-stoichiometric Ni2MnGa are calculated. We find that, in general, the bulk modulus increases with increasing e/a ratio (i.e., the number of valence electrons per atom). The shear moduli C-' and C-44 change oppositely with e/a ratio: C-' decreases but C-44 increases with increasing e/a. However, the Mn-rich Ga-deficient alloys deviate significantly from this general trend. The correlation of calculated elastic moduli and available experimental martensitic transformation temperatures (T-M) demonstrates that the alloy with larger C-' than that of the perfect Ni2MnGa generally possesses lower T-M except for Ni2Mn1+xGa1-x.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 34
  • [1]234Nästa
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy