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Träfflista för sökning "WFRF:(Zheng Lilly S) srt2:(2008)"

Sökning: WFRF:(Zheng Lilly S) > (2008)

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  • Hsu, Fang-Chi, et al. (författare)
  • A multigenic approach to evaluating prostate cancer risk in a systematic replication study
  • 2008
  • Ingår i: Cancer Genetics and Cytogenetics. - ELSEVIER SCIENCE INC. - 0165-4608. ; 183:2, s. 94-98
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Although it is well known that multiple genes may influence prostate cancer risk, most current efforts at identifying prostate cancer risk variants rely on single-gene approaches. In previous work using mostly single-gene approaches, we observed significant associations (P &lt; 0.05) for 6 of 46 polymorphisms in five genes in a Swedish prostate cancer case-control study population. We now report on the higher-order gene-gene interactions among those 46 genetic variants and the combined effect of the six polymorphisms with significant main effects for association with prostate cancer risk in 795 controls and 1,461 cases. Classification and regression tree analysis was used to evaluate higher-order gene-gene interactions. No interactions were confirmed by the result from logistic regressions. For the combined analysis, we tested the hypothesis that individuals carrying multiple copies of risk variants are at increased risk for prostate cancer. Individuals carrying more than eight copies of any risk variant were almost twofold more likely to get prostate cancer (OR = 1.99, P = 0.0014). A significant trend relationship was observed (P &lt; 0.0001). In the present study, additive effects but not multiplicative effects among these six polymorphisms with significant main effects were observed. </p>
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  • Sun, Jielin, et al. (författare)
  • Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
  • 2008
  • Ingår i: Nature Genetics. - London : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 40:10, s. 1153-1155
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • <p>We carried out a fine-mapping study in the <em>HNF1B</em> gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, <img src="http://www.nature.com/__chars/math/special/sim/black/med/base/glyph.gif" />26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with <em>P</em> = 1.7 <img src="http://www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> 10<sup>-9</sup> for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.</p>
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  • Zheng, S. Lilly, et al. (författare)
  • Cumulative association of five genetic variants with prostate cancer
  • 2008
  • Ingår i: New England Journal of Medicine. - MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 358:9, s. 910-919
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background Single-nucleotide polymorphisms (SNPs) in five chromosomal regions -- three at 8q24 and one each at 17q12 and 17q24.3 -- have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger. Methods We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjects with prostate cancer and 1781 control subjects) and assessed the individual and combined association of the SNPs with prostate cancer. Results Multiple SNPs in each of the five regions were associated with prostate cancer in single SNP analysis. When the most significant SNP from each of the five regions was selected and included in a multivariate analysis, each SNP remained significant after adjustment for other SNPs and family history. Together, the five SNPs and family history were estimated to account for 46% of the cases of prostate cancer in the Swedish men we studied. The five SNPs plus family history had a cumulative association with prostate cancer (P for trend, 3.93x10(-28)). In men who had any five or more of these factors associated with prostate cancer, the odds ratio for prostate cancer was 9.46 (P=1.29x10(-8)), as compared with men without any of the factors. The cumulative effect of these variants and family history was independent of serum levels of prostate-specific antigen at diagnosis. Conclusions SNPs in five chromosomal regions plus a family history of prostate cancer have a cumulative and significant association with prostate cancer.</p>
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