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Sökning: WFRF:(Zhu Ning)

  • Resultat 1-10 av 54
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1.
  • Ma, Ming-Guo, et al. (författare)
  • Fabrication and characterization of Ag/calcium silicate core-shell nanocomposites
  • 2011
  • Ingår i: Materials letters (General ed.). - 0167-577X. ; 65:19-20, s. 3069-3071
  • Tidskriftsartikel (refereegranskat)abstract
    • The Ag/calcium silicate nanocomposite with core-shell nanostructure has been successfully synthesized using Ag solution, Ca(NO(3))(2)center dot 4H(2)O and Na(2)SiO(3)center dot 9H(2)O in ethanol/water mixed solvents at room temperature for 48 h. Ag solution was previously prepared by microwave-assisted method in ethylene glycol (EG) at 150 degrees C for 10 min. The nanocomposites consisted of Ag core and an amorphous calcium silicate shell. The XRD and EDS results confirmed that the product was the Ag/calcium silicate nanocomposite. The TEM micrographs indicated that the Ag/calcium silicate nanocomposite was core-shell nanoparticles. The effects of Ca (NO(3))(2)center dot 4H(2)O and Na(2)SiO(3)center dot 9H(2)O concentration on the shells of Ag/calcium silicate nanocomposite were investigated. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and energy-dispersive X-ray spectra (EDS). This method is simple, fast and may be extended to the synthesis of the other kinds of core-shell nanocomposites.
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2.
  • Zhang, Xiaoying, et al. (författare)
  • Expression of MMP-10 in lung cancer
  • 2007
  • Ingår i: Anticancer Research. - International Institute of Anticancer Research. - 0250-7005. ; 27:4C, s. 2791-2795
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a key point in tumor development and expansion. MMP-10 is one of the most important and well-characterized members of the MMP family. In the present study, we examined MMP-10 mRNA and protein levels in non-small cell lung cancer (NSCLC). Patients and Methods: Three endogenous reference genes including GAPDH, beta-actin and 18S rRNA, and MMP-10 mRNA levels were determined using real-time RT-PCR. Immunohistochemical staining was applied to examine MMP-10 protein levels. Both tumor and adjacent normal lung tissues were collected from 32 NSCLC patients. The mRNA levels of GAPDH, beta-actin and 18S rRNA exhibited great differences in tumor tissues and in the adjacent normal tissues. The ratio of mRNA levels in the tumor tissues compared to the adjacent normal tissues followed the pattern GAPDH > beta-actin > 18S rRNA. Thereafter, we chose 18S rRNA as the reference gene for MMP-10 mRNA level determinations. MMP-10 mRNA levels in tumor tissues were significantly lower than those in the adjacent normal tissues (p = 0.0423). However, the MMP- 10 protein levels were higher in the tumor tissues than in the adjacent normal tissues (p=0.0055). The MMP-10 mRNA level was positively-correlated to the MMP-10 protein level in tumor tissues (r=0.4672, p=0.0161), but this correlation was not seen in the adjacent normal tissues (r=-0.0030, p=0.9891). Conclusion: There were no statistical differences in MMP-10 mRNA levels and protein levels in relation to patient's gender, age, tumor stages, tumor size, lymph node metastasis or tumor histological type.
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3.
  • Guo, Xiao-Hua, et al. (författare)
  • Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells
  • 2006
  • Ingår i: APMIS. - Blackwell Publishing Ltd. - 0903-4641. ; 114:12, s. 874-883
  • Tidskriftsartikel (refereegranskat)abstract
    • This study aimed to determine the effects of advanced glycation end products (AGEs) on endothelial cytoskeleton morphology and permeability, and to detect the underlying signaling mechanisms involved in these responses. Cultured endothelial cells (ECs) were exposed to AGE-modified human serum albumin (AGE-HSA), and EC cytoskeletal changes were evaluated by observing fluorescence of F-actin following ligation with labeled antibodies. Endothelial permeability was detected by measuring the flux of TRITC-albumin across the EC monolayers. To explore the signaling pathways behind AGE-induced EC alteration, ECs were treated with either soluble anti-AGE receptor (RAGE) IgG, or the MAPK inhibitors PD98059 and SB203580 before AGE-HSA administration. To further elucidate possible involvement of the ERK and p38 pathways in AGE-induced EC changes, adenovirus-carried recombinant constitutive dominant-negative forms of upstream ERK and p38 kinases, namely MEK1(A) and MKK6b(A), were pre-infected into ECs 24 h prior to AGE-HSA exposure. AGE-HSA induced actin cytoskeleton rearrangement, as well as EC hyperpermeability, in a dose and time-dependent manner. The effects were attenuated in cells pretreated with anti-RAGE IgG, PD98059 or SB203580, respectively. EC pre-infection with MEK1(A) and MKK6b(A) also alleviated the effect of AGEs. Furthermore, adenovirus-mediated administration of activated forms of either MEK1 or MKK6b alone induced rearrangement of F-actin and hyperpermeability. The results indicate that ERK and p38 MAPK play important roles in the mediation of AGE-induced EC barrier dysfunction associated with morphological changes of the F-actin.
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4.
  • Hu, Jing, et al. (författare)
  • Hydrothermal preparation of boehmite-doped AgCl nanocubes and their characterization
  • 2011
  • Ingår i: Materials letters (General ed.). - 0167-577X. ; 65:11, s. 1531-1534
  • Tidskriftsartikel (refereegranskat)abstract
    • A simple hydrothermal route to the preparation of the boehmite-doped AgCl nanocubes using AgNO3,AlCl3 center dot 6H(2)O and NaOH at 200 degrees C for 24 h is reported. The products were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectrometry (FT-IR), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED), UV-vis, thermogravimetric analysis (TGA), and differential thermal analysis (DTA). FE-SEM and TEM micrographs showed that the obtained boehmite-doped AgCl had nanocube-like morphology. The influence of heating temperature on the phase, microstructure, morphology, and thermal stability of the products were also investigated. UV-visible results indicated that the absorption edge moved to higher wavelength with the increasing heating temperature. These materials would be a promising material for photocatalyst applications.
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5.
  • Hudson, Thomas J., et al. (författare)
  • International network of cancer genome projects
  • 2010
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 464:7291, s. 993-998
  • Tidskriftsartikel (refereegranskat)abstract
    • The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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6.
  • Jaskorzynska, Bozena, et al. (författare)
  • Dielectric and Plasmon Slot Waveguides for Photonic Integration
  • 2009
  • Ingår i: ICTON 2009: 11th International Conference on Transparent Optical Networks : 2009 11TH INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS, VOLS 1 AND 2. - NEW YORK : IEEE. ; s. 653-656
  • Konferensbidrag (refereegranskat)abstract
    • Slot waveguides formed either in high-index dielectrics or in metals attract great interest because they provide sub-wavelength confinement in the slot region. While this feature is very attractive for devices relying on stimulated emission or nonlinear effects, it does not necessarily improve the integration density. The spacing between dielectric slot waveguides is still limited by diffraction. Although for metal (plasmon) waveguides the total field can be shrunk far beyond the diffraction limit, the associated increase in propagation loss will set practical limits on both the minimum waveguide width and edge-to-edge separation. Here we compare the packing densities for 3D slot waveguides in silicon and plasmon waveguides in gold with a silicon slot. As a reference we also consider silicon photonic wire. We calculate center-to-center waveguide separations (pitch) versus cross-talk level. We show that at ca 24 dB/mu m cross-talk and requiring the attenuation length of at least 5 mu m, plasmon slot waveguides can be packed ca 3.5 times denser than silicon slot waveguides, and ca 2.5 times denser than photonic wires. We also show examples of the fabricated devices.
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7.
  • Jia, Ning, et al. (författare)
  • Hydrothermal fabrication, characterization, and biological activity of cellulose/CaCO3 bionanocomposites
  • 2012
  • Ingår i: Carbohydrate Polymers. - 0144-8617. ; 88:1, s. 179-184
  • Tidskriftsartikel (refereegranskat)abstract
    • Bionanocomposites with the combination of natural polymers and inorganic nanoparticles may induce unique properties and exhibit promising functions for different applications. Herein, we report a hydrothermal route to the preparation of cellulose/CaCO3 bionanocomposites using the cellulose solution. Ca(NO3)(2)center dot 4H(2)O and Na2SiO3 center dot 9H(2)O. The cellulose solution was previously prepared by the dissolution of microcrystalline cellulose in NaOH-urea aqueous solution. The urea also acts as the CO32- source for the synthesis of CaCO3. The influences of several reaction parameters, such as the heating time, the heating temperature, and the types of additives on the products were investigated by X-ray powder diffraction, Fourier transform infrared spectrometry, scanning electron microscopy, thermogravimetric analysis, and differential thermal analysis. The experimental results demonstrated that the hydrothermal conditions had an effect on the morphology of the bionanocomposites. Cytotoxicity experiments indicated that the cellulose/CaCO3 bionanocomposites had good biocompatibility, so that the bionanocomposites could be ideal candidate for practical biomedical applications.
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8.
  • Jia, Ning, et al. (författare)
  • Hydrothermal Synthesis and Characterization of Cellulose-Carbonated Hydroxyapatite Nanocomposites in NaOH-Urea Aqueous Solution
  • 2010
  • Ingår i: Science of Advanced Materials. - 1947-2935. ; 2:2, s. 210-214
  • Tidskriftsartikel (refereegranskat)abstract
    • Cellulose-carbonated hydroxyapatite (CHA) nanocomposites with CHA nanostructures dispersed in the cellulose matrix have been successfully synthesized using microcrystalline cellulose, CaCl2, and NaH2PO4 in NaOH-urea aqueous solution by hydrothermal method. The cellulose solution was previously prepared by the dissolution of microcrystalline cellulose in NaOH-urea aqueous solution. The effects of the hydrothermal heating time, the heating temperature, and cellulose concentration on the products were investigated. The XRD and FTIR results indicated that the obtained products were the cellulose CHA nanocomposites. The SEM micrographs showed the CHA particles were dispersed in the cellulose matrix. The TGA and DTA indicated the cellulose content in the cellulose-CHA nanocomposites decreased with the decreasing raw cellulose. The size of CHA in nanocomposites decreased with the increasing preparation temperature. The products were characterized by X-ray powder diffraction (XRD), thermogravimetric analysis (TG), differential thermal analysis (DTA), Fourier transform infrared spectrometry (FTIR), and scanning electron microscopy (SEM). This type of cellulose/CHA nanocomposites would be expected to be useful as novel biomedical material.
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9.
  • Jia, Ning, et al. (författare)
  • Microwave-assisted synthesis and characterization of cellulose-carbonated hydroxyapatite nanocomposites in NaOH-urea aqueous solution
  • 2010
  • Ingår i: Materials letters (General ed.). - 0167-577X. ; 64:20, s. 2223-2225
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the microwave-assisted synthesis of the cellulose-carbonated hydroxyapatite (CHA) nanocomposites with CHA nanostructures dispersed in the cellulose matrix by using the cellulose solution, CaCl2, and NaH2PO4. The cellulose solution was previously prepared by the dissolution of microcrystalline cellulose in NaOH-urea aqueous solution. The influences of the heating time and cellulose concentration on the products were also investigated. The X-ray powder diffraction (XRD) and Fourier transform infrared spectrometry (FT-IR) results indicated that the obtained products were the cellulose-CHA nanocomposites. The scanning electron microscopy (SEM) micrographs showed the CHA nanostructures were dispersed in the cellulose matrix. The thermal stability of the cellulose-CHA nanocomposites in air was investigated using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). This method is simple, fast, low-cost and suitable for large-scale production of cellulose-based nanocomposites.
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10.
  • Jia, Ning, et al. (författare)
  • Synthesis and characterization of cellulose-silica composite fiber in ethanol/water mixed solvents
  • 2011
  • Ingår i: BioResources. - 1930-2126. ; 6:2, s. 1186-1195
  • Tidskriftsartikel (refereegranskat)abstract
    • Cellulose-silica composite fiber samples have been successfully synthesized using cellulose solution, tetraethoxysilane, and NH3 center dot H2O in ethanol/water mixed solvents at room temperature for 24 h. The cellulose solution was previously prepared by the dissolution of microcrystalline cellulose in a solvent mixture of N,N-dimethylacetamide (DMAc)/lithium chloride (LiCl). The effect of the tetraethoxysilane concentration on the product was investigated. The products were characterized by X-ray powder diffraction (XRD), thermogravimetric analysis (TG), differential scanning calorimetric analysis (DSC), scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FT-IR), energy-dispersive X-ray spectrum (EDS), and cross polarization magic angle spinning (CP/MAS) solid state C-13-NMR. The morphology of the cellulose-silica composite fiber was investigated by SEM, while their composition was established from EDS measurements combined with the results of FT-IR spectral analysis and XRD patterns. The XRD, FT-IR and EDS results indicated that the obtained product was cellulose-silica composite fiber. The SEM micrographs showed that the silica particles were homogeneously dispersed in the cellulose fiber. The CP/MAS solid state C-13-NMR results indicated that the silica concentration had an influence on the crystallinity of the cellulose. This method is simple for preparation of cellulose-based composites.
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  • Resultat 1-10 av 54
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