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Träfflista för sökning "WFRF:(Zhu Ning) ;pers:(Liu Liu)"

Sökning: WFRF:(Zhu Ning) > Liu Liu

  • Resultat 1-6 av 6
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  • Shi, Leming, et al. (författare)
  • The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
  • 2010
  • Ingår i: Nature Biotechnology. - 1087-0156. ; 28:8, s. 827-838
  • Tidskriftsartikel (refereegranskat)abstract
    • Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.
  • Hudson, Thomas J., et al. (författare)
  • International network of cancer genome projects
  • 2010
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 464:7291, s. 993-998
  • Tidskriftsartikel (refereegranskat)abstract
    • The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
  • Wosinski, Lech, et al. (författare)
  • Photonic crystals for polarization splitting, filtering and sensing
  • 2010
  • Ingår i: 2010 OSA-IEEE-COS Advances in Optoelectronics and Micro/Nano-Optics, AOM 2010. - IEEE Communications Society. - 978-1-4244-8393-8 - 978-1-4244-8392-1
  • Konferensbidrag (refereegranskat)abstract
    • In this paper we discuss different unconventional nanophotonic solutions using photonic crystal-based components including filters, sensors and polarization splitter, which utilizes positive and negative refracted beams. We illustrate them with design, technology and fabricated devices.
  • Wosinski, Lech, et al. (författare)
  • Technology challenges for monolithically integrated waveguide demultiplexers
  • 2009
  • Ingår i: CHINESE OPTICS LETTERS. - 1671-7694. ; 7:4, s. 315-318
  • Tidskriftsartikel (refereegranskat)abstract
    • A short overview of integrated waveguide demultiplexers for different applications ill future highly integrated optical communication systems is presented. Some fabricated devices based on amorphous silicon nanowire technology are described.
  • Schoch, C.L., et al. (författare)
  • Finding needles in haystacks: linking scientific names, reference specimens and molecular data for Fungi
  • 2014
  • Ingår i: Database: The Journal of Biological Databases and Curation. - 1758-0463. ; 2014:bau061, s. 1-21
  • Tidskriftsartikel (refereegranskat)abstract
    • DNA phylogenetic comparisons have shown that morphology-based species recognition often underestimates fungal diversity. Therefore, the need for accurate DNA sequence data, tied to both correct taxonomic names and clearly annotated specimen data, has never been greater. Furthermore, the growing number of molecular ecology and microbiome projects using high-throughput sequencing require fast and effective methods for en masse species assignments. In this article, we focus on selecting and re-annotating a set of marker reference sequences that represent each currently accepted order of Fungi. The particular focus is on sequences from the internal transcribed spacer region in the nuclear ribosomal cistron, derived from type specimens and/or ex-type cultures. Re-annotated and verified sequences were deposited in a curated public database at the National Center for Biotechnology Information (NCBI), namely the RefSeq Targeted Loci (RTL) database, and will be visible during routine sequence similarity searches with NR_prefixed accession numbers. A set of standards and protocols is proposed to improve the data quality of new sequences, and we suggest how type and other reference sequences can be used to improve identification of Fungi.
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