| 1. |
- Afewerki, Samson, et al.
(författare)
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Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications
- 2020
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Ingår i: Nanomedicine. - : Elsevier BV. - 1549-9634 .- 1549-9642. ; 24
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Forskningsöversikt (refereegranskat)abstract
- A vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration.
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| 2. |
- Assis, Talita Oliveira, et al.
(författare)
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CO2emissions from forest degradation in Brazilian Amazon
- 2020
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Ingår i: Environmental Research Letters. - : IOP Publishing. - 1748-9326. ; 15:10
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Forest degradation is widespread around the world, due to multiple factors such as unsustainable logging, agriculture, invasive species, fire, fuelwood gathering, and livestock grazing. In the Brazilian Amazon forest degradation from August 2006 to July 2016 reached 1,1 869 800 ha. The processes of forest degradation are still poorly understood, being a missing component in anthropogenic CO2 emission estimates in tropical forests. In this work, we analyzed temporal trajectories of forest degradation from August 2006 to July 2016 in the Brazilian Amazon and assessed their impact on the regional carbon balance. We combined the degradation process with deforestation-related processes (clear-cut deforestation and secondary vegetation dynamics), using the spatially-explicit INPE-EM carbon emission model. The trajectory analysis showed that 13% of the degraded area ended up being cleared and converted in the period and 61% of the total degraded area experienced only one event of degradation throughout the whole period. Net emissions added up to 5.4 GtCO2, considering the emissions from forest degradation and deforestation, absorption from degraded forest recovery, and secondary vegetation dynamics. The results show an increase in the contribution of forest degradation to net emissions towards the end of the period, related to the decrease in clear-cut deforestation rates, decoupled from the forest degradation rates. The analysis also indicates that the regeneration of degraded forests absorbed 1.8 GtCO2 from August 2006 and July 2016—a component typically overlooked in the regional carbon balance.
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