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Träfflista för sökning "WFRF:(Ahlgren C.) srt2:(2005-2009)"

Sökning: WFRF:(Ahlgren C.) > (2005-2009)

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  • Wilking, N., et al. (författare)
  • Long-term follow-up of the SBG 9401 study comparing tailored FEC-based therapy versus marrow-supported high-dose therapy
  • 2007
  • Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 18:4, s. 694-700
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The purpose was to investigate adjuvant marrow-supportive high-dose chemotherapy compared with an equitoxicity-tailored comparator arm. Patients and methods: Five hundred and twenty-five women below theage of 60 years with operated high-risk primary breast cancer were randomised to nine cycles of granulocyte colony-stimulating factor supported and individually tailored FEC (5-fluorouracil, epirubicin, cyclophosphamide), (n = 251) or standard FEC followed by marrow-supported high-dose therapy with CTCb (cyclophosphamide, thiotepa, carboplatin) therapy (n = 274), followed by locoregional radiotherapy and tamoxifen for 5 years. Results: There were 104 breast cancer relapses in the tailored FEC group versus 139 in the CTCb group (double triangular method by Whitehead, P = 0.046), with a median follow-up of all included patients of 60.8 months. The event-free survival demonstrated 121 and 150 events in the tailored FEC- and CTCb group, respectively [P = 0.074, hazard ratio (HR) 0.804, 95% confidence interval (CI) 0.633-1.022]. Ten patients in the tailored FEC regimen developed acute myeloid leukaemia (AML)/myelodysplasia (MDS). One hundred deaths occurred in the tailored FEC group and 121 in the CTCb group (P = 0.287, HR 0.866, 95% CI 0.665-1.129). Conclusion: The update of this study shows an improved outcome linked to the tailored FEC treatment in relation to breast cancer relapse, but also an increased incidence of AML/MDS. © 2007 Oxford University Press.
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  • Callander, Margarita, 1964-, et al. (författare)
  • Multiple sclerosis immunopathic trait and HLA-DR(2)15 as independent risk factors in multiple sclerosis
  • 2007
  • Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 13:4, s. 441-445
  • Tidskriftsartikel (refereegranskat)abstract
    • We analysed HLA haplotypes in pairs of 78 sporadic multiple sclerosis (MS) patients and 78 healthy siblings. The presence of 2 oligoclonal IgG bands, detected by immunoblotting of the cerebrospinal fluid in healthy siblings, has previously been defined as MS immunopathic trait (MSIT), based on a cut-off derived from healthy unrelated volunteers. The frequency of MSIT was 17.9% (n=14/78 siblings). The HLA-DR(15)2 allelle was present in 21.4% (n=3/14) of the siblings with MSIT, in 40.6% (n =26/64) of the siblings without MSIT, and in 59% (n =46/78) of the patients with clinically-definite (CD) MS. The distribution of zero, one or two HLA-DR(2)15 alleles was significantly skewed towards a lower allelle count in the siblings with MSIT compared with the group of unrelated siblings with MS (P=0.002), and also lower than their related siblings with MS (P=0.1). These results suggest that the MS susceptibility gene, HLA-DR(2)15 type, does not induce MSIT, and conceivably these are two separate risk factors in the development of MS. The effect of HLA-DR(2)15 and MSIT in sporadic MS appears to be synergistic.
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  • Kneider, Maria, et al. (författare)
  • Sequence analysis of human rhinovirus aspirated from the nasopharynx of patients with relapsing-remitting MS.
  • 2009
  • Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 15:4, s. 437-42
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundUpper respiratory infections were reported to trigger multiple sclerosis relapses. A relationship between picornavirus infections and MS relapses was recently reported.ObjectiveTo evaluate whether human rhinovirus is associated with multiple sclerosis relapses and whether any particular strain is predominant.MethodNasopharyngeal fluid was aspirated from 36 multiple sclerosis patients at pre-defined critical time points. Reverse-transcriptase-PCR was performed to detect human rhinovirus-RNA. Positive amplicons were sequenced.ResultsWe found that rhinovirus RNA was present in 17/40 (43%) of specimens obtained at the onset of a URTI in 19 patients, in 1/21 specimens during convalescence after URTI in 14 patients, in 0/6 specimens obtained in 5 patients on average a week after the onset of an "at risk" relapse, occurring within a window in time from one week before to three weeks after an infection, and in 0/17 specimens obtained after the onset of a "not at risk" relapse not associated with any infection in 12 patients. Fifteen specimens from healthy control persons not associated with URTI were negative. The frequency of HRV presence in URTI was similar to that reported for community infections. Eight amplicons from patients represented 5 different HRV strains.ConclusionWe were unable to reproduce previous findings of association between HRV infections and multiple sclerosis relapses. HRV was not present in nasopharyngeal aspirates obtained during "at risk" or "not at risk" relapses. Sequencing of HRV obtained from patients during URTI did not reveal any strain with predominance in multiple sclerosis.
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  • Rehn, Börje, et al. (författare)
  • Symptoms of musculoskeletal disorders among drivers of all-terrain vehicles in northern Sweden
  • 2005
  • Ingår i: Noise and Vibration Worldwide. - : SAGE Publications. - 0957-4565 .- 2048-4062. ; 36:1, s. 13-18
  • Tidskriftsartikel (refereegranskat)abstract
    • All-terrain vehicles (ATVs) are a group of machines that do not operate on prepared roads. Off-road use of these fast-moving machines results in the driver being exposed to high magnitudes of vibration and shock. It is estimated that there are up to 20,000 people in Sweden that uses ATVs during their work, such as forest machines, snowmobiles, snowgroomers, motorcycles, and three- and four-wheeled vehicles. The aim of this cross-sectional study was to investigate the risk for musculoskeletal symptoms of the neck, shoulders, upper and lower back among professional drivers of ATVs. Data from 215 male drivers of forest machines, 137 drivers of snowmobiles, 79 drivers of snowgroomers and 167 men randomly selected from the general population to act as a control group were collected. All subjects were from the four most northern counties in Sweden. Musculoskeletal symptoms during the previous year were assessed using the standardised Nordic questionnaire. Prevalence rate ratios were adjusted for age, smoking and job strain. Results showed that all driver categories had significantly increased prevalence rate ratios (1.5-2.9) for experiencing symptoms in the neck-shoulder and thoracic regions. Unlike findings from previous epidemiological studies, there was not an increased risk of low back pain among any of the driver categories compared to the control group. The higher prevalence of musculoskeletal problems is thought to be due to long-term exposure to physical factors, such as, whole-body vibration (WBV) and shock, static muscle overload and extreme body postures. The findings in this study highlight the fact that working with ATVs may cause, aggravate or prevent resolution of musculoskeletal symptoms. However, the exact cause of these problems is unclear and the interaction between vibration and body posture is not known. The authors believe however that it is necessary to reduce exposure to WBV and shock to decrease the high prevalence of musculoskeletal symptoms among professional ATV drivers. This may be done by implementing preventative measures, such as selecting the best vehicle model or seat, optimising driving style and minimizing use in rough terrain. Health surveillance seems to be important for people that regularly use ATVs in their work.
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