| 1. |
- Andersson-Gäre, Boel, et al.
(författare)
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Incidence and prevalence of juvenile chronic arthritis : a population survey
- 1987
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Ingår i: Annals of the Rheumatic Diseases. - 0003-4967 .- 1468-2060. ; 46:4, s. 277-81
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Tidskriftsartikel (refereegranskat)abstract
- In a population based epidemiological survey of juvenile chronic arthritis (JCA), performed in Western Sweden in 1983, an incidence of 12/100,000 was found. The estimated prevalence was 56/100,000. Subgroup distribution showed a preponderance of mono- and pauciarticular forms. The peak age of onset was between 0 and 4 years of age. Girls predominated over boys in a ratio of 3:2. Overall, 30% were antinuclear antibody (ANA) positive, 9% rheumatoid factor (RF) positive, and eye involvement occurred in 10% of the children. The results suggest differences in population based studies of JCA compared with previously reported hospital based series.
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| 2. |
- Andersson, Rolf E, et al.
(författare)
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Antibacterial activity of plantaricin SIK-83, a bacteriocin produced by Lactobacillus plantarum
- 1988
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Ingår i: Biochimie. - : Elsevier BV. - 0300-9084 .- 1638-6183. ; 70:3, s. 381-390
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Tidskriftsartikel (refereegranskat)abstract
- Lactobacillus plantarum SIK-83 produces a bacteriocin, designated plantaricin SIK-83, which inhibits 66 of 68 lactic acid bacteria from the genera Lactobacillus, Leuconostoc, Pediococcus and Streptococcus. A 500-fold dilution of L. plantarum SIK-83 MRS culture supernatant with phosphate buffer was sufficient to kill 105 cells/ml of Pediococcus pentosaceus within 120s. The killing of a sensitive population followed exponential kinetics. It shown that the bacteriocin binds specifically to sensitive cells but not to nonsensitive lactic acid bacteria, the producer strain or Gram-negative bacteria. Sensitive cells, after exposure to the bacteriocin, could be rescued by treatment with proteolytic enzymes. In buffer, plantaricin SIK-83 was adsorbed to the cell surface almost immediately, and morphological lesions were observed within 2 h after the cells were exposed to the bacteriocin. The lethal mode of action appeared to be due to damage to the cell membrane, resulting in cell lysis, which was detected by electron microscopy and by determination of released intracellular components. © 1988.
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| 3. |
- Andersson, Rolf G, et al.
(författare)
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Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils
- 1989
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Ingår i: Agents and actions. - 0065-4299. ; 27:1-2, s. 25-28
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Tidskriftsartikel (refereegranskat)abstract
- Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.
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| 4. |
- Janson, A M, et al.
(författare)
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Protective effects of chronic nicotine treatment on lesioned nigrostriatal dopamine neurons in the male rat
- 1989
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Ingår i: Progress in Brain Research. - 1875-7855. ; 79, s. 257-265
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Tidskriftsartikel (refereegranskat)abstract
- The present results demonstrate that chronic nicotine treatment can in part protect against mechanically-induced and neurotoxin-induced degeneration of nigrostriatal DA neurons. These results indicate that in sufficient doses chronic treatment with nicotine may be considered in the pharmacological treatment of Parkinson's disease. It remains to be demonstrated whether these protective actions can be extended to include also other injured neurons such as the cholinergic neurons, known to be severely affected in Alzheimer's disease.
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| 5. |
- Andersson, C, et al.
(författare)
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Activation and inhibition of microsomal glutathione transferase from mouse liver.
- 1988
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Ingår i: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 249:3, s. 819-23
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Tidskriftsartikel (refereegranskat)abstract
- Mouse liver microsomal glutathione transferase was purified in an N-ethylmaleimide-activated as well as an unactivated form. The enzyme had a molecular mass of 17 kDa and a pI of 8.8. It showed cross-reactivity with antibodies raised against rat liver microsomal glutathione transferase, but not with any of the available antisera raised against cytosolic glutathione transferases. The fully N-ethylmaleimide-activated enzyme could be further activated 1.5-fold by inclusion of 1 microM-bromosulphophthalein in the assay system. The latter effect was reversible, which was not the case for the N-ethylmaleimide activation. At 20 microM-bromosulphophthalein the activated microsomal glutathione transferase was strongly inhibited, while the unactivated form was activated 2.5-fold. Inhibitors of the microsomal glutathione transferase from mouse liver showed either about the same I50 values for the activated and the unactivated form of the enzyme, or significantly lower I50 values for the activated form compared with the unactivated form. The low I50 values and the steep slope of the activity-versus-inhibitor-concentration curves for the latter group of inhibitors tested on the activated enzyme indicate a co-operative effect involving conversion of activated enzyme into the unactivated form, as well as conventional inhibition of the enzyme.
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| 6. |
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| 7. |
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| 8. |
- Andersson, J, et al.
(författare)
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Experimental and Theoretical Investigation of the Kinetics of the Sorption of Water Vapour by Silica Gel
- 1985
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Ingår i: Journal of the Chemical Society, Faraday Transactions 1: Physcal Chemistry in Condensed Phases. ; 81, s. 2681-2692
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Tidskriftsartikel (refereegranskat)abstract
- The kinetics and mechanism of the sorption reaction between water vapour and silica gel have been investigated in the pressure range 1–50 Torr using thermogravimetry under controlled temperature and water-vapour pressure. Measurements at equilibrium were carried out in order to determine the pertinent equilibrium parameters and the extent of hysteresis. The influence of particle radius and temperature on the kinetics in the whole of the pressure range investigated are well described by theoretical curves fitted to experimental data by taking into account simultaneous mass- and heat-transfer. Calculations yield a diffusivity of 8 × 10–10 m2 s–1. The sorption kinetics in the pressure range 15–40 Torr are shown to be controlled by heat transfer.
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| 9. |
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| 10. |
- Daeschel, M.A., et al.
(författare)
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Microbial ecology of fermenting plant materials
- 1987
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Ingår i: FEMS Microbiology Letters. - 0378-1097 .- 1574-6968. ; 46:3, s. 357-367
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Tidskriftsartikel (refereegranskat)abstract
- The lactic acid fermentation of plant materials is presented from an ecological perspective emphasizing microbial interactions and their influence on the production of fermented plant foods and silage. The plant lactic acid bacteria are discussed in terms of evolution; epiphytic function; physical distribution within fermented material; substrates and products; microbial sequences in fermentation; interactions among species; pure culture fermentation; and starter culture development. © 1987.
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