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- Andersson, Ulrika, et al.
(författare)
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Sex och straff
- 2011
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Ingår i: Festskrift till Per Ole Träskman. ; , s. 24-32
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Bokkapitel (refereegranskat)
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| 6. |
- Andersson, Anastasia, et al.
(författare)
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Two shades of boldness : novel object and anti-predator behavior reflect different personality dimensions in domestic rabbits
- 2014
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Ingår i: Journal of ethology. - : Springer Science and Business Media LLC. - 0289-0771 .- 1439-5444. ; 32:3, s. 123-136
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Tidskriftsartikel (refereegranskat)abstract
- It is increasingly common to quantify and describe behavioral variation in domestic and wild animals in terms of personality. Correlating behavioral traits are referred to as personality dimensions or factors and different dimensions have been reported in different species. Boldness is a well-described personality dimension in several species, although some issues remain unclear. Previous models of boldness include both novelty and risk taking, but recent studies indicate that these types of behaviors may reflect separate personality dimensions. In this study, we developed a behavioral test battery for domestic rabbits, and recorded behaviors of 61 individuals in four different situations (novel object, novel arena, social, and predator interactions). We used domestic rabbits as a model because behavioral variation in rabbits has rarely been quantified in terms of personality dimensions, although rabbit behavior is described. We also wanted to investigate behavioral variation in a Swedish rabbit breed of conservation concern - the Gotland rabbit. Factor analysis of the behavioral test measures suggested three personality dimensions: exploration, boldness, and anxiety. Novel object scores clustered in the exploration and boldness factors, whereas scores associated with predator interactions were explained by anxiety, indicating that novel object and anti-predator behavior reflect different personality dimensions in rabbits.
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| 7. |
- Andersson, Christian, et al.
(författare)
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Maintaining high anaerobic succinic acid productivity by product removal
- 2010
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Ingår i: Bioprocess and biosystems engineering (Print). - : Springer Science and Business Media LLC. - 1615-7591 .- 1615-7605. ; 33:6, s. 711-718
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Tidskriftsartikel (refereegranskat)abstract
- During dual-phase fermentations using Escherichia coli engineered for succinic acid production, the productivity and viable cell concentration decrease as the concentration of succinic acid increases. The effects of succinic acid on the fermentation kinetics, yield, and cell viability were investigated by resuspending cells in fresh media after selected fermentation times. The cellular succinic acid productivity could be restored, but cell viability continuously decreased throughout the fermentations by up to 80% and subsequently the volumetric productivity was reduced. Omitting complex nutrients in the resuspension media had no significant effect on cellular succinate productivity and yield, although the viable cell concentration and thus the volumetric productivity was reduced by approximately 20%. By resuspending the cells, the amount of succinate produced during a 100-h fermentation was increased by more than 60%. The results demonstrate that by product removal succinic acid productivity can be maintained at high levels for extended periods of time.
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| 8. |
- Andersson, Charlotta, et al.
(författare)
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Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma
- 2014
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Ingår i: Cancer Medicine. - : Wiley. - 2045-7634. ; 3:4, s. 909-918
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Tidskriftsartikel (refereegranskat)abstract
- Ovarian carcinoma (OC) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 (WT1) is overexpressed in OCs. Therefore, it is of great interest to investigate whether WT1-specific antibody (Ab) measurements in plasma can serve as a biomarker of anti-OC response, and is of importance in relation to patient prognosis. Peripheral blood samples were obtained from a total of 103 women with ovarian tumors with median being 1 day (range 0-48 days) before operation. WT1 IgG Ab levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis of WT1 protein expression was performed on OC tissue samples. We found that low-WT1 Ab level in plasma was related to improved survival in patients diagnosed at stages III-IV and grade 3 carcinomas. Positive WT1 protein staining on OC tissue samples had a negative impact on survival in the entire cohort, both overall survival (OS) (P = 0.046) and progression-free survival (PFS) (P = 0.006), but not in the serous OC subtype. Combining WT1 IgG Ab levels and WT1 staining, patients with high-WT1 IgG Ab levels in plasma and positive WT1 protein staining in cancer tissues had shorter survival, with a significant association in PFS (P = 0.016). These results indicated that WT1 Ab measurements in plasma and WT1 staining in tissue specimens could be useful as biomarkers for patient outcome in the high-risk subtypes of OCs for postoperative individualized therapy.
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- Andersson, Daniel, 1979, et al.
(författare)
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Plasticity Response in the Contralesional Hemisphere after Subtle Neurotrauma: Gene Expression Profiling after Partial Deafferentation of the Hippocampus
- 2013
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:7
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Tidskriftsartikel (refereegranskat)abstract
- Neurotrauma or focal brain ischemia are known to trigger molecular and structural responses in the uninjured hemisphere. These responses may have implications for tissue repair processes as well as for the recovery of function. To determine whether the plasticity response in the uninjured hemisphere occurs even after a subtle trauma, we subjected mice to a partial unilateral deafferentation of the hippocampus induced by stereotactically performed entorhinal cortex lesion (ECL). The expression of selected genes was assessed by quantitative real-time PCR in the hippocampal tissue at the injured side and the contralesional side at day 4 and 14 after injury. We observed that expression of genes coding for synaptotagmin 1, ezrin, thrombospondin 4, and C1q proteins, that have all been implicated in the synapse formation, re-arrangement and plasticity, were upregulated both in the injured and the contralesional hippocampus, implying a plasticity response in the uninjured hemisphere. Several of the genes, the expression of which was altered in response to ECL, are known to be expressed in astrocytes. To test whether astrocyte activation plays a role in the observed plasticity response to ECL, we took advantage of mice deficient in two intermediate filament (nanofilament) proteins glial fibrillary acidic protein (GFAP) and vimentin (GFAP(-/-) Vim(-/-)) and exhibiting attenuated astrocyte activation and reactive gliosis. The absence of GFAP and vimentin reduced the ECL-induced upregulation of thrombospondin 4, indicating that this response to ECL depends on astrocyte activation and reactive gliosis. We conclude that even a very limited focal neurotrauma triggers a distinct response at the contralesional side, which at least to some extent depends on astrocyte activation.
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| 10. |
- Andersson, Elin, et al.
(författare)
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Uppföljning av biologisk mångfald meddata från Riksskogstaxeringen : Slutrapport, mars 2012
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport redovisar resultatet av ett samarbete mellan två projekt, dels ett projekt inom fortlöpandemiljöanalys på SLU, lett av Artdatabanken, dels ett projekt som letts av Länsstyrelsen i Jämtlandtillsammans med Artdatabanken och Skogsstyrelsen. Det senare drivs som ett så kallat miljömålsprojekt,med medel från Naturvårdsverket. I båda projekten är Riksskogstaxeringen en samarbetspartner.Grundtanken i båda projekten är att undersöka vilka parametrar i Riksinventeringen av skog (RIS) sombäst speglar tillståndet för biologisk mångfald.I ett första steg har arbetsgruppen valt ut ett antal parametrar som bör tas fram och undersökas. I ett andrasteg har SLU tagit fram ett bakgrundsmaterial som diskuterats vidare inom gruppen. Därefter har gruppentagit fram ett preliminärt förslag på vilka parametrar som kan vara lämpliga att prioritera för uppföljningav miljömålen. Förslaget har remitterats till forskare och myndigheter som kan tänkas ha intresse avinnehållet och inkomna synpunkter har inarbetats i föreliggande slutrapport. Innehållet kan utgöralämpligt bakgrundsmaterial om tillståndet i skogen, men också som indikatorer och andra mått som kananvändas på olika sätt i uppföljning av biologisk mångfald.Övergripande kan det konstateras att RIS ger värdefull kunskap om främst utvecklingen av skogligastrukturer som trädens ålder, trädslag, beståndsålder och andra kvaliteter. Denna information kan bidra tillatt beskriva förutsättningarna för den biologiska mångfalden. Ett flertal av parametrarna har haft enpositiv utveckling under miljömålsperioden. Det är däremot inte liktydigt med att utvecklingen för denbiologiska mångfalden utvecklats i en positiv riktning. Detta på grund av att de nivåer som vi har att utgåfrån (1999) ofta ligger på en så låg nivå jämfört med många arters behov att det krävs kraftigaförändringar för att arterna ska kunna utvecklas i positiv riktning.Projektet har hitintills prioriterat drygt ett tjugotal skogliga parametrar för uppföljning av biologiskmångfald inom miljömålssystemet. Av de skogliga parametrarna har följande föreslagits få hög prioritet:•Antal gamla träd över 121 år per kvadratkilometer, indelat i åldersklasser•Areal gammal skog fördelad på skogstyper; tall, gran, barr (ädel, barrädel, barrlöv)•Volym död ved av olika trädslag; tall, gran, löv•Volym död ved av olika grovlek•Areal ädellövskog indelad i åldersklasser•Areal ädellövskog fördelat på olika klasser för mängden död vedDe arter och spårtecken från inventeringen som särskilt uppmärksammats är:•Hackmärken•Vedsvamp•Tickor•Mjölkört•Hänglavar; man- och skägglav
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