| 21. |
- Cashin, Peter, et al.
(författare)
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Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy : a retrospective study of in vitro drug sensitivity and survival
- 2011
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Ingår i: Clinical Colorectal Cancer. - : Elsevier BV. - 1533-0028 .- 1938-0674. ; 10:2, s. 108-112
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study was to present results on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) of appendiceal adenocarcinoid (MC) with peritoneal carcinomatosis (PC), to assess drug sensitivity of AAC, as compared with colorectal cancer (CRC), and to report any discordant histopathology. Methods: Ten patients were treated with CRS and HIPEC. Treatment, drug sensitivity profiles, histopathology, and survival data were recorded and matched with potential prognostic indicators. Drug sensitivity was assessed with short-term fluorometric microculture cytotoxicity assay and compared with peritoneal metastases from CRC. Results: Patients with completeness of cytoreduction score (CC) 1 (16.4 months). In the CC 1 group. For standard drugs, tumor cells from MC and CRC were equally sensitive; except for docetaxel, to which MC was more sensitive than CRC. Conclusion: The CC-score correlated with overall survival. Candidates for this type of treatment should be referred early for evaluation in order to reach a better CC score. Drugs used for CRC also seem adequate for treatment of MC, although other drugs, eg, docetaxel, might be more active.
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| 22. |
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| 23. |
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| 24. |
- Morén, Håkan, et al.
(författare)
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Angiography and mfERG show that blood supply to the pig retina may be both ipsilateral and contralateral.
- 2013
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Ingår i: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 54:9, s. 6112-6117
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: We recently presented a transfemoral endovascular coiling technique for inducing experimental retinal ischemia in pigs. Substantial variation was seen in the degree of ischemia. It was hypothesized that the blood supply to the retina may originate from both the ipsi- and contralateral ophthalmic arteries, and that there may be an interconnecting artery between the eyes. Methods: The external carotid system of ten pigs was catheterized using a fluoroscopy- monitored, transfemoral, endovascular approach. Vascular occlusion was achieved in the ophthalmic artery using coils. The effect of occlusion was examined using angiography and multifocal electroretinography (mfERG). Results: During angiography of the ophthalmic artery on one side, contrast filling was seen in the retinas on both sides, suggesting that the ophthalmic artery on one side may supply both retinas. A blood vessel connecting the eyes was visualized. mfERG recordings showed that the use of coiling to occlude the ophthalmic artery had greater ischemic effects in eyes that depended mainly on the ipsilateral ophthalmic artery for blood supply and smaller ischemic effect in retinas that received blood from both the ipsilateral and contralateral ophthalmic artery via the interconnecting vessel. Conclusions: The blood supply to the retina may originate from both the ipsi- and contralateral ophthalmic artery in the pig. There is an interindividual variability in the ischemic effect of occlusion depending on the architecture of the vasculature. These findings may be important in the development of new animal models of experimental retinal ischemia, since arterial occlusion in one eye may affect the blood supply to the contralateral eye.
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| 25. |
- Morén, Håkan, et al.
(författare)
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Endovascular Coiling of the Ophthalmic Artery in Pigs to Induce Retinal Ischemia
- 2011
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Ingår i: Investigative Ophthalmology & Visual Science. - : Association for Research in Vision and Ophthalmology (ARVO). - 1552-5783. ; 52:7, s. 4880-4885
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was investigated. METHODS. The ophthalmic artery was catheterized through the external carotid system using a fluoroscopy-monitored, transfemoral, endovascular approach in 12 pigs (mean weight, 70 kg). The effects were evaluated using angiography and multifocal electroretinography. RESULTS. Occlusion of arteries supplying the retina was established using endovascular coiling. Coiling in the proximal part of the ophthalmic artery caused no or little ischemia, presumably because of collateral blood supply. Coiling in the distal part of the ophthalmic artery, over the branching of the main ciliary artery, caused more severe retinal ischemia. Multifocal electroretinography recordings, which reflect retinal function in an area close to the visual streak, showed decreased amplitudes and increased implicit times after distal occlusion, but not after proximal occlusion of the ophthalmic artery. The responses were similar 1 hour and 72 hours after coiling, indicating that a permanent ischemic injury was established. CONCLUSIONS. The porcine ophthalmic artery can be occluded using an endovascular coiling technique. This provides an experimental animal model of retinal ischemia in which occlusion at different sites of the vasculature produces different degrees of severity of the ischemic damage. (Invest Ophthalmol Vis Sci. 2011;52:4880-4885) DOI:10.1167/iovs.11-7628
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| 26. |
- Morén, Håkan, et al.
(författare)
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Multifocal electroretinogram for functional evaluation of retinal injury following ischemia-reperfusion in pigs.
- 2010
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Ingår i: Graefe's Archive for Clinical and Experimental Ophthalmology. - : Springer Science and Business Media LLC. - 1435-702X .- 0721-832X. ; 248, s. 627-634
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Multifocal electroretinogram (mfERG) has the power to discriminate between localized functional losses and overall retinal changes when evaluating retinal injury. So far, full-field ERG has been the gold standard for examining retinal ischemia and the effects of different neuroprotectants in experimental conditions. The aim of the present study was to establish mfERG, with simultaneous fundus monitoring, for analyzing the localized functional response in the retina after ischemia-reperfusion in the porcine eye. METHODS: 70 kg pigs underwent pressure-induced retinal ischemia (1 hour) followed by reperfusion. mfERG recordings were obtained before and after ischemia, followed by 1 and 5 hours of reperfusion. Individual components of the summed mfERG responses were correlated to ischemia and the time of reperfusion. RESULTS: The visual streak area had significantly higher amplitudes than the optic nerve head and the area in between, suggesting that the mfERG monitors localized functional retinal responses. The mfERG recordings were altered following ischemia-reperfusion. In one group of animals, there was a complete flattening of the mfERG waveforms, indicating complete ischemic injury. In the other group of animals, ischemia-reperfusion altered the mfERG such that the implicit time was increased (20.82 +/- 0.18 before ischemia and 21.57 +/- 0.21 after ischemia and 1 hour of reperfusion, in the visual streak area, p < 0.05) and the amplitude was decreased (13.16 +/- 2.3 before ischemia and 11.47 +/- 0.88 after ischemia and 1 hour of reperfusion, in the visual streak area, p < 0.001), suggesting partial ischemic injury. CONCLUSIONS: In conclusion, the porcine model of pressure-induced retinal ischemia-reperfusion results in mfERG changes, typical for retinal ischemia. mfERG may be a useful tool for evaluating and monitoring localized cone dysfunction after an ischemic injury.
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