Search: WFRF:(Armstrong Nicola J.)
> (2018) >
A Meta-Analysis of ...
A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood
-
- Jiang, Jiyang (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia
-
- Thalamuthu, Anbupalam (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia
-
- Ho, Jennifer E. (author)
- Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA
-
show more...
-
- Mahajan, Anubha (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
-
- Ek, Weronica E (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
-
- Brown, David A. (author)
- St Vincents Hosp, St Vincents Ctr Appl Med Res, Darlinghurst, NSW, Australia;Westmead Inst Med Res, Inst Clin Pathol & Med Res, Westmead, NSW, Australia;Westmead Hosp, Westmead, NSW, Australia
-
- Breit, Samuel N. (author)
- St Vincents Hosp, St Vincents Ctr Appl Med Res, Darlinghurst, NSW, Australia
-
- Wang, Thomas J. (author)
- Vanderbilt Univ, Dept Med, Div Cardiol, Nashville, TN USA
-
- Gyllensten, Ulf B. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
-
- Chen, Ming-Huei (author)
- NHLBI, Populat Sci Branch, NIH, Framingham, MA USA;Framingham Heart Dis Epidemiol Study, Framingham, MA USA
-
- Enroth, Stefan, 1976- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
-
- Januzzi, James L., Jr. (author)
- Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA 02114 USA
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
-
- Armstrong, Nicola J. (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia;Murdoch Univ, Math & Stat, Perth, WA, Australia
-
- Kwok, John B. (author)
- Neurosci Res Australia, Randwick, NSW, Australia;Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
-
- Schofield, Peter R. (author)
- Neurosci Res Australia, Randwick, NSW, Australia;Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
-
- Wen, Wei (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia;Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia
-
- Trollor, Julian N. (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia;Univ New South Wales, Sch Psychiat, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia
-
- Johansson, Åsa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
-
- Morris, Andrew P. (author)
- Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England
-
- Vasan, Ramachandran S. (author)
- Boston Univ, Sch Med, Dept Med, Sect Prevent Med, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Epidemiol Sect, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Cardiol Sect, Boston, MA 02118 USA;Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Natl Heart Lung & Blood Inst, Boston, MA USA;Boston Univ, Framingham Heart Study, Boston, MA 02215 USA
-
- Sachdev, Perminder S. (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia;Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia
-
- Mather, Karen A. (author)
- Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia
-
show less...
-
(creator_code:org_t)
- 2018-03-23
- 2018
- English.
-
In: Frontiers in Genetics. - : Frontiers Media S.A.. - 1664-8021. ; 9
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.frontier...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Blood levels of growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), have been associated with various pathological processes and diseases, including cardiovascular disease and cancer. Prior studies suggest genetic factors play a role in regulating blood MIC-1/GDF-15 concentration. In the current study, we conducted the largest genome-wide association study (GWAS) to date using a sample of similar to 5,400 community-based Caucasian participants, to determine the genetic variants associated with MIC-1/GDF-15 blood concentration. Conditional and joint (COJO), gene-based association, and gene-set enrichment analyses were also carried out to identify novel loci, genes, and pathways. Consistent with prior results, a locus on chromosome 19, which includes nine single nucleotide polymorphisms (SNPs) (top SNP, rs888663, p = 1.690 x 10(-35)), was significantly associated with blood MIC-1/GDF-15 concentration, and explained 21.47% of its variance. COJO analysis showed evidence for two independent signals within this locus. Gene-based analysis confirmed the chromosome 19 locus association and in addition, a putative locus on chromosome 1. Gene-set enrichment analyses showed that the "COPI-mediated anterograde transport" gene-set was associated with MIC-1/GDF15 blood concentration with marginal significance after FDR correction (p = 0.067). In conclusion, a locus on chromosome 19 was associated with MIC-1/GDF-15 blood concentration with genome-wide significance, with evidence for a new locus (chromosome 1). Future studies using independent cohorts are needed to confirm the observed associations especially for the chromosomes 1 locus, and to further investigate and identify the causal SNPs that contribute to MIC-1/GDF-15 levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- genome-wide association study
- growth differentiation factor-15
- macrophage inhibitory cytokine-1
- community-based individuals
- chromosome 19
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Jiang, Jiyang
-
Thalamuthu, Anbu ...
-
Ho, Jennifer E.
-
Mahajan, Anubha
-
Ek, Weronica E
-
Brown, David A.
-
show more...
-
Breit, Samuel N.
-
Wang, Thomas J.
-
Gyllensten, Ulf ...
-
Chen, Ming-Huei
-
Enroth, Stefan, ...
-
Januzzi, James L ...
-
Lind, Lars
-
Armstrong, Nicol ...
-
Kwok, John B.
-
Schofield, Peter ...
-
Wen, Wei
-
Trollor, Julian ...
-
Johansson, Åsa
-
Morris, Andrew P ...
-
Vasan, Ramachand ...
-
Sachdev, Permind ...
-
Mather, Karen A.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Frontiers in Gen ...
- By the university
-
Uppsala University