| 1. |
- Traven, G., et al.
(författare)
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The GALAH survey : multiple stars and our Galaxy: I. A comprehensive method for deriving properties of FGK binary stars?
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 638
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Tidskriftsartikel (refereegranskat)abstract
- Context. Binary stellar systems form a large fraction of the Galaxy's stars. They are useful as laboratories for studying the physical processes taking place within stars, and must be correctly taken into account when observations of stars are used to study the structure and evolution of the Galaxy. The advent of large-scale spectroscopic and photometric surveys allows us to obtain large samples of binaries that permit characterising their populations.Aims. We aim to obtain a large sample of double-lined spectroscopic binaries (SB2s) by analysis of spectra from the GALAH survey in combination with photometric and astrometric data. A combined analysis will provide stellar parameters of thousands of binary stars that can be combined to form statistical observables of a given population. We aim to produce a catalogue of well-characterised systems, which can in turn be compared to models of populations of binary stars, or to follow-up individual systems of interest.Methods. We obtained a list of candidate SB2 systems from a t-distributed stochastic neighbour embedding (t-SNE) classification and a cross-correlation analysis of GALAH spectra. To compute parameters of the primary and secondary star, we used a Bayesian approach that includes a parallax prior from Gaia DR2, spectra from GALAH, and apparent magnitudes from APASS, Gaia DR2, 2MASS, and WISE. We used a Markov chain Monte Carlo approach to sample the posterior distributions of the following model parameters for the two stars: T-eff[1,T-2], logg([1,2]), [Fe/H], V-r[1,V-2], v(mic[1,2]), v(broad[1,2]), R-[1,R-2], and E(B-V).Results. We present results for 12 760 binary stars detected as SB2s. We construct the statistical observables T-1/T-2, Delta V-r, and R-1/R-2, which demonstrate that our sample mostly consists of dwarfs, with a significant fraction of evolved stars and several dozen members of the giant branch. The majority of these binary stars is concentrated at the lower boundary of the Delta V-r distribution, and the R-1/R-2 ratio is mostly close to unity. The derived metallicity of our binary stars is statistically lower than that of single dwarf stars from the same magnitude-limited sample.Conclusions. Our sample of binary stars represents a large population of well-characterised double-lined spectroscopic binaries that are appropriate for statistical studies of the binary populations. The derived stellar properties and their distributions show trends that are expected for a population of close binary stars (a < 10 AU) detected through double lines in their spectra. Our detection technique allows us to probe binary systems with mass ratios 0.5 q <= 1.
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| 2. |
- Amarsi, Anish, et al.
(författare)
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The GALAH Survey : non-LTE departure coefficients for large spectroscopic surveys
- 2020
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 642
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Tidskriftsartikel (refereegranskat)abstract
- Massive sets of stellar spectroscopic observations are rapidly becoming available and these can be used to determine the chemical composition and evolution of the Galaxy with unprecedented precision. One of the major challenges in this endeavour involves constructing realistic models of stellar spectra with which to reliably determine stellar abundances. At present, large stellar surveys commonly use simplified models that assume that the stellar atmospheres are approximately in local thermodynamic equilibrium (LTE). To test and ultimately relax this assumption, we have performed non-LTE calculations for 13 different elements (H, Li, C, N, O, Na, Mg, Al, Si, K, Ca, Mn, and Ba), using recent model atoms that have physically-motivated descriptions for the inelastic collisions with neutral hydrogen, across a grid of 3756 1D MARCS model atmospheres that spans 3000 <= T-eff/K <= 8000, - 0.5 <= log g/cm s(-2) <= 5.5, and - 5 <= [Fe/H] <= 1. We present the grids of departure coefficients that have been implemented into the GALAH DR3 analysis pipeline in order to complement the extant non-LTE grid for iron. We also present a detailed line-by-line re-analysis of 50 126 stars from GALAH DR3. We found that relaxing LTE can change the abundances by between - 0.7 dex and + 0.2 dex for different lines and stars. Taking departures from LTE into account can reduce the dispersion in the [A/Fe] versus [Fe/H] plane by up to 0.1 dex, and it can remove spurious differences between the dwarfs and giants by up to 0.2 dex. The resulting abundance slopes can thus be qualitatively different in non-LTE, possibly with important implications for the chemical evolution of our Galaxy. The grids of departure coefficients are publicly available and can be implemented into LTE pipelines to make the most of observational data sets from large spectroscopic surveys.
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| 3. |
- Holmgren, Gustav, 1983-, et al.
(författare)
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Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases
- 2020
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 21:2
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Tidskriftsartikel (refereegranskat)abstract
- There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We investigated the potential of hiPS-HEP as an in vitro model for metabolic diseases by combining transcriptomics with multiple functional assays. The transcriptomics analysis revealed that 86% of the genes were expressed at similar levels in hiPS-HEP as in human primary hepatocytes (hphep). Adult characteristics of the hiPS-HEP were confirmed by the presence of important hepatocyte features, e.g., Albumin secretion and expression of major drug metabolizing genes. Normal energy metabolism is crucial for modeling metabolic diseases, and both transcriptomics data and functional assays showed that hiPS-HEP were similar to hphep regarding uptake of glucose, low-density lipoproteins (LDL), and fatty acids. Importantly, the inflammatory state of the hiPS-HEP was low under standard conditions, but in response to lipid accumulation and ER stress the inflammation marker tumor necrosis factor alpha (TNF alpha) was upregulated. Furthermore, hiPS-HEP could be co-cultured with primary hepatic stellate cells both in 2D and in 3D spheroids, paving the way for using these co-cultures for modeling non-alcoholic steatohepatitis (NASH). Taken together, hiPS-HEP have the potential to serve as an in vitro model for metabolic diseases. Furthermore, differently expressed genes identified in this study can serve as targets for future improvements of the hiPS-HEP.
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| 4. |
- Viñuela, Ana, et al.
(författare)
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Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
- 2020
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4912-4912
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Tidskriftsartikel (refereegranskat)abstract
- Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic traits, and human pancreatic islet transcription using data from 420 donors. We find: (a) 7741 cis-eQTLs in islets with a replication rate across 44 GTEx tissues between 40% and 73%; (b) marked overlap between islet cis-eQTL signals and active regulatory sequences in islets, with reduced eQTL effect size observed in the stretch enhancers most strongly implicated in GWAS signal location; (c) enrichment of islet cis-eQTL signals with T2D risk variants identified in genome-wide association studies; and (d) colocalization between 47 islet cis-eQTLs and variants influencing T2D or glycemic traits, including DGKB and TCF7L2. Our findings illustrate the advantages of performing functional and regulatory studies in disease relevant tissues.
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| 5. |
- Walming, Sofie, et al.
(författare)
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Quality of life in patients with resectable rectal cancer during the first 24 months following diagnosis
- 2020
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Ingår i: Colorectal Disease. - : Wiley. - 1462-8910 .- 1463-1318. ; 22:12, s. 2028-2037
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Tidskriftsartikel (refereegranskat)abstract
- Aim An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient's needs. The aim of the study was to describe the quality of life during the 24 months following diagnosis and to identify risk factors for poor quality of life. Method This is a prospective cohort study of patients with rectal cancer followed up by extensive questionnaires. Patients from 16 surgical departments in Denmark and Sweden from 2012 to 2015 were included. The self-assessed quality of life was measured with a seven-point Likert scale. Results A total of 1110 patients treated with curative intent were included, and the response rate at the 24-month follow-up was 71%. Patients with rectal cancer assessed their quality of life before start of treatment as poorer than that of a reference population. At the 12- and 24-month follow-up, the quality of life on group level had recovered to the same level as for the reference population. Risk factors for poor quality of life included bother with urinary, bowel and stoma function. A reference population was used for comparison. Conclusion The quality of life of patients with resectable rectal cancer recovered to levels comparable to a reference population 12 and 24 months after diagnosis. Our results indicate that the urinary, bowel and stoma function has an impact on quality of life.
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