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- Svensson, Johan, 1964, et al.
(författare)
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Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.
- 1998
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Ingår i: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 0884-0431. ; 13:7, s. 1158-66
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Tidskriftsartikel (refereegranskat)abstract
- The effect of 2 months of treatment with the oral growth hormone (GH) secretagogue MK-677 on markers of bone metabolism was determined in healthy obese male subjects. This was a randomized, double-blind, parallel, placebo-controlled study. Twenty-four healthy obese males, 19-49 years of age, with body mass index > 30 kg/m2 were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. MK-677 increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels and a 28% increase in procollagen III peptide levels were seen with as little as 2 weeks of MK-677 treatment (p < 0.01 and p = 0.001 vs. placebo, respectively) while a 15% increase in serum levels of osteocalcin was not detected until 8 weeks of treatment (p < 0.01 vs. placebo). Markers of bone resorption were induced within 2 weeks of treatment with MK-677; serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen were increased 26% at 8 weeks (p = 0.001 vs. placebo), and urine hydroxyproline/creatinine and calcium/creatinine ratios at 8 weeks were increased by 23% (p < 0.05 vs. placebo) and 46% (p < 0.05 vs placebo), respectively, MK-677 increased serum insulin-like growth factor binding protein-5 (IGFBP-5) by 43-44% after 2-8 weeks of treatment (p < 0.01 vs. placebo). Serum IGFBP-4 was increased by 25% after 2 weeks of treatment (p < 0.001 vs. placebo) but no significant change from baseline was observed after 8 weeks of treatment. Plasma interleukin-6 was not significantly changed by active treatment. In conclusion, short-term treatment of healthy obese male volunteers with the GH secretagogue MK-677 increases markers of both bone resorption and formation. Large increases in serum levels of IGF-1 and IGFBP-5 and a transient increase in serum IGFBP-4 were found. Future long-term studies are needed to investigate if prolonged treatment with MK-677 increases bone mass.
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- Bendz, D., et al.
(författare)
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Kinematic wave model for water movement in municipal solid waste
- 1998
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Ingår i: Water Resources Research. - 0043-1397. ; 34:11, s. 2963-2970
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Tidskriftsartikel (refereegranskat)abstract
- The movement of water in a large (3.5 m(3)) undisturbed sample of 22-year-old municipal solid waste has been modeled using a kinematic wave approximation for unsaturated infiltration and internal drainage. The model employs a two-parameter power expression as macroscopic flux law. The model parameters were determined and interpreted in terms of the internal geometry of the waste medium by fitting the model to one set of infiltration and drainage data. The model was validated using another set of data from a sequence of water input events. The results of the validation show that the model performs satisfactorily, but further development of the model to incorporate spatial variability would increase its capability.
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- Bobba, A. G., et al.
(författare)
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Application of a watershed runoff model to north-east pond river, Newfoundland: To study water balance and hydrological characteristics owing to atmospheric change
- 1997
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Ingår i: Hydrological Processes. - 1099-1085. ; 11:12, s. 1573-1593
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Tidskriftsartikel (refereegranskat)abstract
- The hydrological sensitivities to long-term climate change of a watershed in Eastern Canada were analysed using a deterministic watershed runoff model developed to simulate watershed acidification. This model was modified to study atmospheric change effects in the watershed. Water balance modelling techniques, modified for assessing climate effects, were developed and tested for a watershed using atmospheric change scenarios from both state of the art general circulation models and a series of hypothetical scenarios. The model computed daily surface, inter- and groundwater hows from the watershed. The moisture, infiltration and recharge rate are also computed in the soil reservoirs. The thirty years of simulated data can be used to evaluate the effects of climatic change on soil moisture, recharge rate and surface and subsurface flow systems. The interaction between surface and subsurface water is discussed in relation to climate change. These hydrological results raise the possibility of major environmental and socioeconomic difficulties and have significant implications for future water resource planning and management. (C) 1997 John Wiley & Sons, Ltd.
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