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Träfflista för sökning "WFRF:(Best T) ;srt2:(2020-2023)"

Sökning: WFRF:(Best T) > (2020-2023)

  • Resultat 21-22 av 22
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21.
  • Šnidariać, Iva, et al. (författare)
  • LOFAR Deep Fields: Probing faint Galactic polarised emission in ELAIS-N1
  • 2023
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 674
  • Tidskriftsartikel (refereegranskat)abstract
    • We present the first deep polarimetric study of Galactic synchrotron emission at low radio frequencies. Our study is based on 21 observations of the European Large Area Infrared Space Observatory Survey-North 1 (ELAIS-N1) field using the Low-Frequency Array (LOFAR) at frequencies from 114.9 to 177.4 MHz. These data are a part of the LOFAR Two-metre Sky Survey Deep Fields Data Release 1. We used very low-resolution (4.3') Stokes QU data cubes of this release. We applied rotation measure (RM) synthesis to decompose the distribution of polarised structures in Faraday depth, and cross-correlation RM synthesis to align different observations in Faraday depth. We stacked images of about 150 h of the ELAIS-N1 observations to produce the deepest Faraday cube at low radio frequencies to date, tailored to studies of Galactic synchrotron emission and the intervening magneto-ionic interstellar medium. This Faraday cube covers ∼36 deg2 of the sky and has a noise of 27 μJy PSF-1 RMSF-1 in polarised intensity. This is an improvement in noise by a factor of approximately the square root of the number of stacked data cubes (√20), as expected, compared to the one in a single data cube based on five-to-eight-hour observations. We detect a faint component of diffuse polarised emission in the stacked cube, which was not detected previously. Additionally, we verify the reliability of the ionospheric Faraday rotation corrections estimated from the satellite-based total electron content measurements to be of ∼0.05 Cyrillic small letter GHEad m-2. We also demonstrate that diffuse polarised emission itself can be used to account for the relative ionospheric Faraday rotation corrections with respect to a reference observation.
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22.
  • Sol, Nik, et al. (författare)
  • Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma
  • 2020
  • Ingår i: Cell Reports Medicine. - : Elsevier. - 2666-3791. ; 1:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA profile of TEPs from glioblastoma patients with multiple sclerosis and brain metastasis patients (validation series, n = 157; accuracy, 80%; AUC, 0.81 [95% CI, 0.74-0.89; p < 0.001]). Second, analysis of patients with glioblastoma versus asymptomatic healthy controls in an independent validation series (n = 347) provided a detection accuracy of 95% and AUC of 0.97 (95% CI, 0.95-0.99; p < 0.001). Finally, we developed the digitalSWARM algorithm to improve monitoring of glioblastoma progression and demonstrate that the TEP tumor scores of individual glioblastoma patients represent tumor behavior and could be used to distinguish false positive progression from true progression (validation series, n = 20; accuracy, 85%; AUC, 0.86 [95% CI, 0.70-1.00; p < 0.012]). In conclusion, TEPs have potential as a minimally invasive biosource for blood-based diagnostics and monitoring of glioblastoma patients.
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