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Faecal microbiota t...
Faecal microbiota transfer in patients with microscopic colitis : a pilot study in collagenous colitis
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- Holster, Savanne (författare)
- Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
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- Rode, Julia, 1992- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Bohr, Johan, 1957- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Department of Gastroenterology
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- Kumawat, Ashok Kumar, 1982- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre
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- Veress, Gábor (författare)
- Department of Laboratory Medicine, Faculty for Medicine and Health, Örebro University, Örebro, Sweden; Örebro University Hospital, Örebro, Swed
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- Hultgren Hörnquist, Elisabeth, 1965- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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(creator_code:org_t)
- 2020-11-03
- 2020
- Engelska.
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Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:12, s. 1454-1466
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https://oru.diva-por... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Objectives: Faecal microbiota transfer (FMT) consists of the infusion of donor faecal material into the intestine of patients with the aim to restore a disturbed gut microbiota. Methods: In this pilot study (NCT03275467), the effect of three repeated FMTs (day 0, two weeks, four weeks) was studied and followed up for six months in nine collagenous colitis (CC) patients, using two stool donors. Results: Five patients had an active disease at the time of baseline sampling. The primary endpoint (remission at six weeks, defined as <3 stools whereof <1 watery stool per day) was achieved by two of these patients, and by one at eight weeks. Overall, in all nine patients, FMT did not result in a significant reduction of watery stools, assessed by daily diary. However, diarrhoea (assessed by gastrointestinal symptom rating scale) was significantly improved at four (p = .038) and eight weeks (p = .038), indigestion at eight (p = .045) and 12 weeks (p = .006), disease-related worries at four (p = .027) and eight weeks (p = .027), and quality of life at six months (p = .009). FMT resulted in an increased number of lamina propria lymphocytes, possibly indicating an initial mucosal immune activation. No serious adverse events, no systemic effects, and no changes in faecal calprotectin and psychological symptoms were observed. Conclusions: FMT is able to improve symptoms in a yet undefined subset of CC patients. Further studies could help to characterise this subset and to understand if these results can be generalised to all microscopic colitis patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Faecal microbiota transplantation
- microscopic colitis
- collagenous colitis
- gut microbiota
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Holster, Savanne
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Rode, Julia, 199 ...
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Bohr, Johan, 195 ...
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Kumawat, Ashok K ...
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Veress, Gábor
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Hultgren Hörnqui ...
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Brummer, Robert ...
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König, Julia, 19 ...
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Örebro universitet