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- Benhamou, S, et al.
(författare)
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Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
- 2002
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 23:8, s. 1343-1350
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Tidskriftsartikel (refereegranskat)abstract
- Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including >18 000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.07-1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publication bias in our results. A pooled analysis of the original data of about 9500 subjects involved in 21 case-control studies from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of GSTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95% CI 0.98-1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.
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- Bellotti, E., et al.
(författare)
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Monte Carlo calculation of hole initiated impact ionization in 4H phase SiC
- 2000
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Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 87:8, s. 3864-3871
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we present a comprehensive, full band theoretical study of the high field, hole transport properties of the 4H phase of silicon carbide (4H-SiC). The calculations are performed using a full band ensemble Monte Carlo simulation that includes numerically tabulated impact ionization rates, and phonon and ionized impurity scattering rates. In addition, the simulation includes a mechanism, interband tunneling, by which the holes can move between bands in the proximity of band intersection points, It is found that there exists a significant anisotropy in the calculated steady-state hole drift velocity for fields applied parallel and perpendicular to the c-axis direction. Good agreement with experimental measurements of the hole initiated impact ionization coefficient for fields applied along the c axis is obtained, provided that interband tunneling in the proximity of band intersections is included in the model. If interband tunneling is not included, the calculated ionization coefficients are orders of magnitude lower than the experimental measurements. © 2000 American Institute of Physics.
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- Brennan, K.F., et al.
(författare)
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Monte Carlo modeling of wurtzite and 4H phase semiconductor materials
- 2001
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Ingår i: VLSI design (Print). - 1065-514X .- 1563-5171. - 0852617046 ; 13:1-4, s. 117-124
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Tidskriftsartikel (refereegranskat)abstract
- We present a discussion of the complexities encountered in particle simulation models for noncubic symmetry materials, focusing on the wurtzite and 4H phases of semiconductors. We have identified three general issues, band structure, scattering mechanisms, and band intersections, which in our opinion, constitute the most important modifications to Monte Carlo simulators for cubic symmetry materials. Owing to the increased number of atoms and size of the unit cell, the band structure is far more complex in wurtzite and 4H polytypes than in zincblende phase semiconductors. This added complexity is reflected by the greater number of bands, smaller Brillouin zone and concomitant increase in the number of band intersections. We have found that the band intersection points greatly influence the transport dynamics. In this paper, we discuss our initial attempts at treating transport near these points
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