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Träfflista för sökning "WFRF:(Broderick Peter) srt2:(2005-2009)"

Sökning: WFRF:(Broderick Peter) > (2005-2009)

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1.
  • Ding, Li, et al. (författare)
  • Somatic mutations affect key pathways in lung adenocarcinoma
  • 2008
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 455:7216, s. 1069-1075
  • Tidskriftsartikel (refereegranskat)abstract
    • Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.
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2.
  • Gallo, Katia, et al. (författare)
  • Buried slab waveguides in LiNbO3 nonlinear photonic crystals
  • 2005
  • Ingår i: Proceedings of WFOPC 2005. - 0780389492 ; , s. 36-40
  • Konferensbidrag (refereegranskat)abstract
    • We present an efficient integrated device for SHG at telecom wavelengths in Hexagonally Poled LiNbO3, based on the reverse proton exchange waveguide technology. We discuss its nonlinear response in terms of power, wavelength and angle tunability and use the experimental SHG data to infer also information on the linear properties of the waveguide.
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3.
  • Gallo, Katia, et al. (författare)
  • Guided-wave second-harmonic generation in a LiNbO3 nonlinear photonic crystal
  • 2006
  • Ingår i: Optics Letters. - 0146-9592 .- 1539-4794. ; 31:9, s. 1232-1234
  • Tidskriftsartikel (refereegranskat)abstract
    • We demonstrate twin-beam second-harmonic generation from telecommunications wavelengths in an optimized buried reverse proton exchanged planar waveguide made in 2D hexagonally poled LiNbO3. Experiments carried out with a nanosecond narrow-bandwidth, high-power fiber source thoroughly explored the response of the nonlinear photonic crystal device in terms of its power, wavelength, and angle tunability.
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  • Resultat 1-4 av 4

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