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Träfflista för sökning "WFRF:(Burger K) srt2:(2020-2021)"

Search: WFRF:(Burger K) > (2020-2021)

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  • Burger, Stefan, et al. (author)
  • A new polar perovskite coordination network with azaspiroundecane as A-site cation
  • 2020
  • In: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; 49:31, s. 10740-10744
  • Journal article (peer-reviewed)abstract
    • ABX(3) perovskite coordination networks are a rapidly growing subclass of crystalline coordination networks. At present, synthetic efforts in the field are dominated by the use of commercially available building blocks, leaving the potential for tuning properties via targeted compositional changes largely untouched. Here we apply a rational crystal engineering approach, using 6-azaspiro[5.5]undecane ([ASU](+)) as A-site cation for the synthesis of the polar perovskite [ASU][Cd(C2N3)(3)].
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  • Ferrer, G, et al. (author)
  • Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL
  • 2021
  • In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:11, s. 3163-3175
  • Journal article (peer-reviewed)abstract
    • Cancer pathogenesis involves the interplay of tumor- and microenvironment-derived stimuli. Here we focused on the influence of an immunomodulatory cell type, myeloid-derived suppressor cells (MDSCs), and their lineage-related subtypes on autologous T lymphocytes. Although MDSCs as a group correlated with an immunosuppressive Th repertoire and worse clinical course, MDSC subtypes (polymorphonuclear, PMN-MDSC, and monocytic, M-MDSCs) were often functionally discordant. In vivo, PMN-MDSCs existed in higher numbers, correlated with different Th-subsets, and more strongly associated with poor clinical course than M-MDSCs. In vitro, PMN-MDSCs were more efficient at blocking T-cell growth and promoted Th17 differentiation. Conversely, in vitro M-MDSCs varied in their ability to suppress T-cell proliferation, due to the action of TNFα, and promoted a more immunostimulatory Th compartment. Ibrutinib therapy impacted MDSCs differentially as well, since after initiating therapy, PMN-MDSC numbers progressively declined, whereas M-MDSC numbers were unaffected, leading to a set of less immunosuppressive Th cells. Consistent with this, clinical improvement based on decreasing CLL-cell numbers correlated with the decrease in PMN-MDSCs. Collectively, the data support a balance between PMN-MDSC and M-MDSC numbers and function influencing CLL disease course.
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  • Result 1-9 of 9

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