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- Carlsson, Anders, et al.
(författare)
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Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays.
- 2008
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 44:3, s. 472-480
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Tidskriftsartikel (refereegranskat)abstract
- The driving force behind oncoproteomics is to identify biomarker signatures associated with a particular malignancy. Here, we have for the first time used large-scale recombinant scFv antibody microarrays in an attempt to classify metastatic breast cancer versus healthy controls, based on differential protein expression profiling of whole serum samples. Using this multiplexed and miniaturised assay set-up providing pM range sensitivities, breast cancer could be classified with a specificity and sensitivity of 85% based on 129 serum analytes. However, by adopting a condensed 11 analyte biomarker signature, composed of nine non-redundant serum proteins, we were able to distinguish cancer versus healthy serum proteomes with a 95% sensitivity and specificity, respectively. When a subgroup of patients, not receiving anti-inflammatory drugs, was analysed, a novel eight analyte biomarker signature with a further improved predictive power was indicated. In a longer perspective, antibody microarray analysis could provide a tool for the development of improved diagnostics and intensified biomarker discovery for breast cancer patients.
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- Gulliksson, Mårten, 1963-, et al.
(författare)
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Surface Fitting with NURBS - a Gauss Newton with Trust Region Approach : 13th WSEAS International Conference on APPLIED MATHEMATICS Puerto de la Cruz, SPAIN, DEC 15-17, 2008
- 2008
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Ingår i: APPLIED AND COMPUTATIONAL MATHEMATICS, 2ND EDITION. - AG LOANNOU THEOLOGOU 17-23, 15773 ZOGRAPHOU, ATHENS, GREECE : World Scientific and Engineering Academy and Society. - 9789604740345 ; , s. 169-174
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Konferensbidrag (refereegranskat)abstract
- This paper shows a new approach for non-linear least squares fitting with NURBS as curves and surfaces to measured data by the Gauss-Newton method. A Trust Region algorithm is used to reach global convergence as well as variable substitution and simple bounds.
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- Lund Ohlsson, Marie
(författare)
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New methods for movement technique development in cross-country skiing using mathematical models and simulation
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This Licentiate Thesis is devoted to the presentation and discussion of some new contributions in applied mathematics directed towards scientific computing in sports engineering. It considers inverse problems of biomechanical simulations with rigid body musculoskeletal systems especially in cross-country skiing. This is a contrast to the main research on cross-country skiing biomechanics, which is based mainly on experimental testing alone. The thesis consists of an introduction and five papers. The introduction motivates the context of the papers and puts them into a more general framework. Two papers (D and E) consider studies of real questions in cross-country skiing, which are modelled and simulated. The results give some interesting indications, concerning these challenging questions, which can be used as a basis for further research. However, the measurements are not accurate enough to give the final answers. Paper C is a simulation study which is more extensive than paper D and E, and is compared to electromyography measurements in the literature. Validation in biomechanical simulations is difficult and reducing mathematical errors is one way of reaching closer to more realistic results. Paper A examines well-posedness for forward dynamics with full muscle dynamics. Moreover, paper B is a technical report which describes the problem formulation and mathematical models and simulation from paper A in more detail. Our new modelling together with the simulations enable new possibilities. This is similar to simulations of applications in other engineering fields, and need in the same way be handled with care in order to achieve reliable results. The results in this thesis indicate that it can be very useful to use mathematical modelling and numerical simulations when describing cross-country skiing biomechanics. Hence, this thesis contributes to the possibility of beginning to use and develop such modelling and simulation techniques also in this context.
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- Nilsson, Lennart, et al.
(författare)
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Bra immunsvar av vaccination mot difteri, stelkramp och kikhosta i årskurs 4 : Lokala reaktioner mycket vanliga – och förväntade
- 2009
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 106:38, s. 2357-2361
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Tidskriftsartikel (refereegranskat)abstract
- Acellulärt kikhostevaccin, difterivaccin och stelkrampsvaccin gav bra serologiska svar vid påfyllnadsvaccination vid 10 års ålder. Även skolbarn som aldrig fått kikhostevaccin svarade med antikroppar mot kikhosta efter endast en dos acellulärt kikhostevaccin.Lokala biverkningar som ont i armen, rodnad/svullnad och klåda var mycket vanliga, och dessa lokalreaktioner höll i sig vanligtvis 3–4 dagar.Större lokala reaktioner om minst fem centimeters rodnad eller svullnad drabbade mellan vart tredje till vart sjätte barn.Dessa reaktioner är ofarliga, men det är viktigt att korrekt informera skolelever och föräldrar om vilka vanliga reaktioner som kan förväntas vid påfyllnadsvaccination mot difteri, stelkramp och kikhosta i denna ålder.
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