| 1. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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| 2. |
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| 3. |
- Adare, A., et al.
(författare)
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Heavy-flavor electron-muon correlations in p plus p and d plus Au collisions at root s(NN)=200 GeV
- 2014
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 89:3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Heavy-flavor modification in relativistic p(d) + A collisions are sensitive to different kinds of strong-interaction physics ranging from modifications of the nuclear wave function to initial- and final-state energy loss. Modifications to single heavy-flavor particles and their decay leptons at midrapidity and forward rapidity are well established at the Relativistic Heavy Ion Collider (RHIC). Purpose: This paper presents measurements of azimuthal correlations of electron-muon pairs produced from heavy-flavor decays, primarily c (c) over bar, in root s(NN) = 200 GeV p + p and d + Au collision using the PHENIX detector at RHIC. The electrons are measured at midrapidity while the muons in the pair are measured at forward rapidity, defined as the direction of the deuteron beam, in order to utilize the deuteron to probe low-x partons in the gold nucleus. Methods: This analysis uses the central spectrometer arms for electron identification and forward spectrometer arms for muon identification. Azimuthal correlations are built in all sign combinations for e-mu pairs. Subtracting the like-sign yield from the unlike-sign yield removes the correlations from light flavor decays and conversions. Results: Comparing the p + p results with several different Monte Carlo event generators, we find the results are consistent with a total charm cross section sigma(c (c) over bar) = 538 +/- 46 (stat) +/- 197 (data syst) +/- 174 (model syst) mu b. These generators also indicate that the back-to-back peak at Delta phi = pi is dominantly from the leading-order contributions (gluon fusion), while higher-order processes (flavor excitation and gluon splitting) contribute to the yield at all Delta phi. We observe a suppression in the pair yield per collision in d + Au. We find the pair yield suppression factor for 2.7 < Delta phi < 3.2 rad is J(dA) = 0.433 +/- 0.087 (stat) +/- 0.135 (syst). Conclusions: The e-mu pairs result from partons at x(Au) similar to 10(-2) at Q(2) = 10 GeV/c(2) at the edge of the shadowing region. The pair suppression indicates modification to c (c) over bar pairs for these kinematics in the cold nuclear medium at RHIC.
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| 4. |
- Adare, A., et al.
(författare)
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Measurement of transverse-single-spin asymmetries for midrapidity and forward-rapidity production of hadrons in polarized p plus p collisions at root s=200 and 62.4 GeV
- 2014
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368. ; 90:1
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of transverse-single-spin asymmetries (A(N)) in p + p collisions at root s = 62.4 and 200 GeV with the PHENIX detector at the Relativistic Heavy Ion Collider are presented. At midrapidity, A(N) is measured for neutral pion and eta mesons reconstructed from diphoton decay, and, at forward rapidities, neutral pions are measured using both diphotons and electromagnetic clusters. The neutral-pion measurement of A(N) at midrapidity is consistent with zero with uncertainties a factor of 20 smaller than previous publications, which will lead to improved constraints on the gluon Sivers function. At higher rapidities, where the valence quark distributions are probed, the data exhibit sizable asymmetries. In comparison with previous measurements in this kinematic region, the new data extend the kinematic coverage in root s and p(T), and it is found that the asymmetries depend only weakly on root s. The origin of the forward A(N) is presently not understood quantitatively. The extended reach to higher p(T) probes the transition between transverse momentum dependent effects at low p(T) and multiparton dynamics at high p(T).
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| 5. |
- Aad, G., et al.
(författare)
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- 2014
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Aad, G., et al.
(författare)
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- 2014
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Tidskriftsartikel (refereegranskat)
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| 7. |
- Aad, G., et al.
(författare)
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- 2014
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Aad, G., et al.
(författare)
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- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:4
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Tidskriftsartikel (refereegranskat)
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| 9. |
- Aad, G., et al.
(författare)
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- 2014
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:9
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Tidskriftsartikel (refereegranskat)
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| 10. |
- Aad, G., et al.
(författare)
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- 2014
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Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5
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Tidskriftsartikel (refereegranskat)
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