Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials

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Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials

Clarke, Robert (author): University of Oxford

Brattström, L. (author): Lund University

Landgren, F. (author): Lund University

Israelsson, B. (author): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine

Lindgren, A. (author): Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine

Hultberg, B. (author): Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine

Andersson, A (author): Lund University

Cuskelly, G. (author): University of Ulster

McNulty, H. (author): University of Ulster

Strain, S. S. (author): University of Ulster

McPartlin, J. (author): Trinity College Dublin

Weir, D. G. (author): Trinity College Dublin

Scott, J. M. (author): Trinity College Dublin

den Heijer, H. (author): Radboud University Nijmegen

Brouwer, I. A. (author): Radboud University Nijmegen

Blom, H. J. (author): Radboud University Nijmegen

Bos, G. M.J. (author): Radboud University Nijmegen

Spaans, A. (author): Radboud University Nijmegen

Rosendaal, F. R. (author): Radboud University Nijmegen

Thomas, C. M.G. (author): Radboud University Nijmegen

Haak, H. L. (author): Radboud University Nijmegen

Wijermans, P. W. (author): Radboud University Nijmegen

Gerrits, W. B.J. (author): Radboud University Nijmegen

Naurath, H. J. (author): Catholic University of Leuven

Joosten, E. (author): Catholic University of Leuven

Riezler, R. (author): Catholic University of Leuven

Stabler, S. P. (author): Catholic University of Leuven

Allen, R. H. (author): Catholic University of Leuven

Lindenbaum, J. (author): Catholic University of Leuven

Pietrzik, K. (author): University of Bonn

PrinzLangenohl, R. (author): University of Bonn

Dierkes, J. (author): University of Bonn

Saltzman, E. (author): Tufts University

Mason, J. B. (author): Tufts University

Jacques, P. (author): Tufts University

Selhub, J. (author): Tufts University

Salem, D. (author): Tufts University

Schaefer, E. (author): Tufts University

Rosenberg, I. H. (author): Tufts University

Ubbink, J. (author): University of Pretoria

van der Mere, A. (author): University of Pretoria

Vermack, W. J.H. (author): University of Pretoria

Delport, R. (author): University of Pretoria

Becker, P. J. (author): University of Pretoria

Potgieter, H. C. (author): University of Pretoria

Woodside, J. V. (author): Queen's University Belfast

Yarnell, J. W.G. (author): Queen's University Belfast

McMaster, D. (author): Queen's University Belfast

Young, I. S. (author): Queen's University Belfast

McCrum, E. E. (author): Queen's University Belfast

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(creator_code:org_t)

BMJ, 1998
1998
English.
In: British Medical Journal. - : BMJ. - 0959-8146. ; 316:7135, s. 894-898

Related links:: https://www.ncbi.nlm... (free); show more...; http://dx.doi.org/10...; https://www.bmj.com/...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Research review (peer-reviewed)

Abstract Subject headings

Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid based supplements on blood homocysteine concentration. Multivariate regression analysis was used to determine the effects on homocysteine concentrations of different doses of folic acid and of the addition of vitamin B-12 or B-6. Subjects: Individual data on 1114 people included in 12 trials. Findings: The proportional and absolute reductions in blood homocysteine produced by folic acid supplements were greater at higher pretreatment blood homocysteine concentrations (P < 0.001) and at lower pretreatment blood folate concentrations (P < 0.001). After standardisation to pretreatment blood concentrations of homocysteine of 12 μmol/l and of folate of 12 nmol/l (approximate average concentrations for Western populations), dietary folic acid reduced blood homocysteine concentrations by 25% (95% confidence interval 23% to 28%; P < 0.001), with similar effects in the range of 0.5-5 mg folic acid daily. Vitamin B-12 (mean 0.5 mg daily) produced an additional 7% (3% to 10%) reduction in blood homocysteine. Vitamin B-6 (mean 16.5 mg daily) did not have a significant additional effect. Conclusions: Typically in Western populations, daily supplementation with both 0.5-5 mg folic acid and about 0.5 mg vitamin B-12 would be expected to reduce blood homocysteine concentrations by about a quarter to a third (for example, from about 12 μmol/l to 8-9 μmol/l). Large scale randomised trials of such regimens in high risk populations are now needed to determine whether lowering blood homocysteine concentrations reduces the risk of vascular disease.

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By the author/editor: Clarke, Robert; Brattström, L.; Landgren, F.; Israelsson, B.; Lindgren, A.; Hultberg, B.; show more...; Andersson, A; Cuskelly, G.; McNulty, H.; Strain, S. S.; McPartlin, J.; Weir, D. G.; Scott, J. M.; den Heijer, H.; Brouwer, I. A.; Blom, H. J.; Bos, G. M.J.; Spaans, A.; Rosendaal, F. R.; Thomas, C. M.G.; Haak, H. L.; Wijermans, P. W.; Gerrits, W. B.J.; Naurath, H. J.; Joosten, E.; Riezler, R.; Stabler, S. P.; Allen, R. H.; Lindenbaum, J.; Pietrzik, K.; PrinzLangenohl, ...; Dierkes, J.; Saltzman, E.; Mason, J. B.; Jacques, P.; Selhub, J.; Salem, D.; Schaefer, E.; Rosenberg, I. H.; Ubbink, J.; van der Mere, A.; Vermack, W. J.H.; Delport, R.; Becker, P. J.; Potgieter, H. C.; Woodside, J. V.; Yarnell, J. W.G.; McMaster, D.; Young, I. S.; McCrum, E. E.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: British Medical ...; BMJ

By the university: Lund University

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Lowering blood homocysteine with folic acid based supplements : Meta-analysis of randomised trials

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