| 1. |
- Dunham, I, et al.
(författare)
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The DNA sequence of human chromosome 22
- 1999
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
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| 4. |
- Auce, A, et al.
(författare)
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Reaction cross sections for 38, 65, and 97 MeV deuterons on targets from Be-9 to Pb-208
- 1996
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Ingår i: PHYSICAL REVIEW C-NUCLEAR PHYSICS. - : AMER INST PHYSICS. - 0556-2813. ; 53:6, s. 2919-2925
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Reaction cross sections for deuterons have been measured for Be-9, C-12, O-16, Si-28, Ca-40,Ca-48, Ni-58,Ni-60, Sn-112,Sn-116,Sn-120,Sn-124, and Pb-208 at 37.9, 65.5, and 97.4 MeV.
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| 5. |
- Achcar, JA, et al.
(författare)
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25 years of applied statistics
- 1998
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Ingår i: JOURNAL OF APPLIED STATISTICS. - : CARFAX PUBL CO. - 0266-4763. ; 25:1, s. 3-22
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Andersson Dunstan, Christina, et al.
(författare)
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Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays
- 1997
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Ingår i: Journal of Ethnopharmacology. - 0378-8741 .- 1872-7573. ; 57:1, s. 35-56
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Tidskriftsartikel (refereegranskat)abstract
- In our ongoing program to find new anti-inflammatory compounds, 58 extracts from 46 different medicinal plant species, used in treatment of inflammatory disorders - 38 plants from the traditional medicine of Western Samoa and eight originating from the indigenous medicine of the Shipibo-Conibo tribe of Peruvian Amazonia - were evaluated. The ability of all extracts to inhibit cyclooxygenase-1 catalysed prostaglandin biosynthesis in vitro was examined. Of the plant species tested 14 showed moderate to strong inhibition; including 11 Samoan and three Peruvian species. Further, 12 Samoan and all eight Peruvian species were investigated on their inhibitory activity of ethyl phenylpropiolate induced rat ear oedema in vivo Significant activity was shown by 10 of the Samoan and by all eight Peruvian species. An additional evaluation of the most active species was provided through a compilation of existing literature documenting traditional medicinal uses, pharmacological activity and chemical constituents. Several known cyclooxygenase-l inhibitors were reported to which the observed pharmacological activity can be attributed at least partly. The combination of chemical and pharmacological literature data and our experimental data may help to explain the anti-inflammatory use of these species in indigenous medicine.
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| 7. |
- Dalziel, J E, et al.
(författare)
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A threonine residue in the M2 region of the beta1 subunit is needed for expression of functional alpha1beta1 GABA(A) receptors.
- 1999
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Ingår i: European Journal of Pharmacology. - 0014-2999 .- 1879-0712. ; 370:3, s. 345-8
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Tidskriftsartikel (refereegranskat)abstract
- Although there is a high degree of homology in the M2 transmembrane segments of alpha1 and beta1 subunits, subunit-specific effects were observed in alpha1beta1 GABA(A) receptors expressed in Spodoptera frugipedra (Sf9) cells when the conserved 13' threonine residue in the M2 transmembrane region was mutated to alanine. When threonine 263 (13') was mutated to alanine in the beta1 subunit, high-affinity muscimol binding and the response to GABA were abolished. This did not occur when the threonine 263 (13') was mutated to alanine in the alpha1 subunit, but the rate of desensitisation increased and the effect of bicuculline, a competitive inhibitor, was reduced. The results show differential effects of subunits on receptor function and support a role for M2 in desensitisation.
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