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Sökning: WFRF:(Dale Caroline E) > (2011)

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1.
  • Artigas Soler, María, et al. (författare)
  • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
  • 2011
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:11, s. 1082-90
  • Tidskriftsartikel (refereegranskat)abstract
    • Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
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2.
  • Limburg, Karin E., et al. (författare)
  • Tracking Baltic hypoxia and cod migration over millennia with natural tags
  • 2011
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 108:22, s. E177-E182
  • Tidskriftsartikel (refereegranskat)abstract
    • Growing hypoxic and anoxic areas in coastal environments reduce fish habitat, but the interactions and impact on fish in these areas are poorly understood. Using natural tag properties of otoliths, we found significant correlations between the extent of Baltic Sea hypoxia and Mn/Ca ratios in regions of cod (Gadus morhua) otoliths corresponding to year 1 of life; this is associated with elevated bottom water dissolved manganese that increases with hypoxia. Elevated Mn/Ca ratios were also found in other years of life but with less frequency. We propose that cod exhibiting enhanced Mn/Ca ratios were exposed to dissolved manganese from hypoxia-induced redox dynamics in nursery areas. Neolithic (4500 B. P.) cod otoliths (n = 12) had lowlevels of Mn/Ca ratios, consistent with low hypoxia, but a single otolith dated to the younger Iron Age had a distinct growth band with an elevated Mn/Ca ratio. Sr/Ca patterns reflecting changes in environmental salinity and temperature were similar in both modern and Stone Age otoliths, indicating consistent migration habits across time, and Ba/Sr ratios in modern cod otoliths indicate increasing use of a more saline habitat with age. Using elemental ratios, numerous existing archival collections of otoliths could provide the means to reconstruct hypoxia exposure histories and major patterns of fish movement near dead zones globally.
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