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| 2. |
- Fagerberg, Linn, et al.
(författare)
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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
- 2014
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 13:2, s. 397-406
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Tidskriftsartikel (refereegranskat)abstract
- Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody- based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to 80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.
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| 3. |
- Danielsson, Jens, et al.
(författare)
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Global structural motions from the strain of a single hydrogen bond
- 2013
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 110:10, s. 3829-3834
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Tidskriftsartikel (refereegranskat)abstract
- The origin and biological role of dynamic motions of folded enzymes is not yet fully understood. In this study, we examine the molecular determinants for the dynamic motions within the beta-barrel of superoxide dismutase 1 (SOD1), which previously were implicated in allosteric regulation of protein maturation and also pathological misfolding in the neurodegenerative disease amyotrophic lateral sclerosis. Relaxation-dispersion NMR, hydrogen/deuterium exchange, and crystallographic data show that the dynamic motions are induced by the buried H43 side chain, which connects the backbones of the Cu ligand H120 and T39 by a hydrogen-bond linkage through the hydrophobic core. The functional role of this highly conserved H120-H43-T39 linkage is to strain H120 into the correct geometry for Cu binding. Upon elimination of the strain by mutation H43F, the apo protein relaxes through hydrogen-bond swapping into a more stable structure and the dynamic motions freeze out completely. At the same time, the holo protein becomes energetically penalized because the twisting back of H120 into Cu-bound geometry leads to burial of an unmatched backbone carbonyl group. The question then is whether this coupling between metal binding and global structural motions in the SOD1 molecule is an adverse side effect of evolving viable Cu coordination or plays a key role in allosteric regulation of biological function, or both?
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| 5. |
- Danielsson, Martin, 1982-
(författare)
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Digitala distinktioner : Klass och kontinuitet i unga mäns vardagliga mediepraktiker
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This dissertation explores how social class matters in young men’s everyday relationship to digital media. The aim is to contribute to the existing knowledge about how young people incorporate digital media in their everyday lives by focusing on the structural premises of this process. It also presents an empirically grounded critique of popular ideas about young people as a “digital generation”, about the internet as a socially transformative force, and about class as an increasingly redundant category.The empirical material consists of qualitative interviews with 34 young men (16-19 years) from different class backgrounds, upper secondary schools and study programmes. Drawing on the conceptual tools of Pierre Bourdieu, three classes are constructed: the “cultural capital rich”, the “upwardly mobile”, and the “cultural capital poor”.The analysis shows that class, through the workings of habitus, structures the young men’s relationship to school and future aspirations. This also engenders class-distinctive ways of conceiving leisure and digital media use. Through their class habitus and taste, the young men tend to orient themselves and navigate in different ways in what they perceive as a space of digital goods and practices, endowed with different symbolic value in school and society. The “cultural capital rich” are drawn to-wards practices capable of yielding symbolic profit in the field of education and beyond, whereas the other classes gravitate towards the “illegitimate” digital culture but deal with this different ways.These findings indicate that there are social and cultural continuities at play within recent technological changes. They also expose the structural differences hidden by sweeping statements about young people as a “digital generation”. Finally, they show that class, contrary to popular beliefs about “the death of class”, still represents a pertinent analytical category.
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| 6. |
- Danielsson, Martin, 1982-
(författare)
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New media, habitus and the problem of voice : The case of young men in Sweden
- 2012
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Konferensbidrag (refereegranskat)abstract
- In enabling “ordinary people” to participate in the public sphere, new media are often celebrated as a democratizing force. And even if the projected egalitarian world of new media is yet to come, it is frequently believed to be an inevitable effect of the coming of age of the so-called “the digital generation”, who have grown up with these media and so have come to incorporate their democratic potentials.This hyperbolic optimism about new media rests on a flawed technological determinism. We cannot presume that the possibility of online participation amounts to an actual process of democratization. Being able to make one’s voice heard is not the same as being listened to and acknowledged, nor is it the same as exercising this ability. Nevertheless, much debate and research on young people’s new media use has been implicitly based on this premise. Little attention has been paid to the structures, mechanisms and contexts that enable and constrain online participatory practices among young people.As part of my ongoing PhD project this paper sets out to identify forms and patterns of online participation and non-participation among 34 Swedish boys (16-19 years) from different class backgrounds. Drawing on qualitative interview data and the conceptual tools of Pierre Bourdieu, it also tries to grasp some of the processes engendering these forms and patterns.Preliminary analyses suggest that the sense of having “the right to speak” (or not) in different matters seems to shape whether, how, and where the boys participate online. This sense is rooted in habitus and as such in their different class backgrounds. The boys privileged in terms of capital tend to participate with greater ease insofar as they feel that their voice matters in most matters, whereas the disprivileged boys seem to feel that their voice matters in a more limited range of matters, most of them generally regarded as trivial.
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| 7. |
- Danielsson, Martin, 1982-
(författare)
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On the Classified and Classifying Consumption of Digital Media : Initial Findings from a Comparative Case Study of Young Men in Sweden
- 2010
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Konferensbidrag (refereegranskat)abstract
- New media in general and the internet in particular are regularly ascribed with various democratizing potentials. According to politicians, journalists, marketers and even some academics, the proliferation of internet access (via broadband) will bring about a shift in the power relations between media industries and media consumers, between governments and citizens, between professionals and amateurs, etc. Young people are often conceptualized as a driving force in this change, in so far as growing up in this new communication environment is considered enough for making real the potentials of new media. These simplistic ideas draw from technological deterministic assumptions and must be put into question by detailed empirical analyses. Although this has been done to a certain extent, previous research on young people’s consumption of new media has tended to focus on their creative, playful and more or less particular (or peripheral) digital interpretations and interactions. The social structures producing and reproducing themselves through (the lack of) these interactions, on the other hand, have seldom been taken into account. By and large, questions of social power relations such as class, gender and race/ethnicity are missing. Building primarily on the ideas of technology-as-text as elaborated within the context of cultural studies and on Pierre Bourdieu’s sociology of culture – including concepts such as habitus, capital (economic, cultural, social, symbolic), social fields, symbolic power, etc. – my PhD project constitutes an attempt to fill this gap. More specifically, it aims at qualitatively examining the ways in which 16-18 years old Swedish boys with different positions in social space conceive, relate to and make use of the internet as a differentiating and potentially enabling technology in their everyday lives. This will be done through a series of case studies. This paper presents and problematizes some initial findings from a pilot study carried out in the autumn of 2009, when twelve young men from four upper secondary schools (preparing either for further education or directly for the working life) in one of Sweden’s largest cities were interviewed individually. An intercultural comparison between boys occupying different positions in social space (i.e. the discernible volume and composition of their families’ accumulated capital) reveal divergent perceptions of the school, further education and one’s future more generally, which also tend to have a bearing on their readings of the internet. The preliminary analyses suggest that, in general, these socially structured readings of the internet are carried out in ways that serve to reproduce existing power relations rather than dissolving them. The boys from families with large cultural capital perceive the internet as a resource for accumulating forms of capital that can be employed in the struggle for positions to which they aspire. For example, they stress its various possibilities for learning. The boys having less cultural capital at their disposal, on the other hand, often articulate a narrower outlook, reducing the new technology to an instrument for immediate amusement or just passing time. Hence, the democratizing potentials of new media seem to be unequally realized.
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| 8. |
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| 9. |
- Lindell, Johan, 1985-, et al.
(författare)
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(Mediated) cosmopolitanism as symbolic violence
- 2014
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The notions of a “mediated cosmopolitanism”, a “global imagined community” and an “imagined cosmopolitanism” speak of a cosmopolitan opportunism gaining ground in contemporary media and communication studies. This line of research tends to epistemologically situate human beings exclusively as users or audiences of media. The risk by such a media-centric focus is to confine oneself to the question of “what the media does to people”. By understanding users and audiences of potentially global media as contextualized social agents we engage with the relationship between cosmopolitanism and the media from a different vantage point. Our media sociological perspective insists on accounting for social context, and so we turn to the question of how classified social agents classify the contemporary media landscape as gateways to the wider world. What emerges in our qualitative and quantitative data is a pattern of social reproduction by way of cultural distinction – agents strong on cultural capital is particularly prone to approach the media landscape as an avenue for cosmopolitan socialization. There is thus reason to question the universalizing rhetoric pertaining to notions of a “mediated cosmopolitanism”.
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