| 1. |
- Kraen, M., et al.
(författare)
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Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking
- 2019
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 14:2
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Tidskriftsartikel (refereegranskat)abstract
- Background Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods 450 middle-aged subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12. Due to missing data 33 subjects were excluded. Results The remaining 417 participants were divided into 4 different groups. Group I (n = 157, no plaque and no COPD), group II (n = 136, plaque but no COPD), group III (n = 43, COPD but no plaque) and group IV (n = 81, plaque and COPD). Serum levels of MMP-1,-7,-10-12 were significantly influenced by smoking, and MMP-1, -3, -7 and-12 were elevated in subjects with COPD and carotid plaque. This remained statistically significant for MMP-1 and-12 after adjusting for traditional risk factors. Conclusion COPD and concomitant plaque in the carotid artery were associated with elevated levels of MMP-1 and -MMP-12 even when adjusting for risk factors. Further studies are needed to elucidate if these two MMP´s could be useful as biomarkers in a clinical setting. Smoking was associated with increased serum levels of MMP´s (except for MMP-3) and should be taken into account when interpreting serum MMP results.
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| 2. |
- Stenevi Lundgren, S., et al.
(författare)
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Low physical activity is related to clustering of risk factors for fracture—a 2-year prospective study in children
- 2017
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Ingår i: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 28:12, s. 3373-3378
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Tidskriftsartikel (refereegranskat)abstract
- Summary: The study investigates the effect of physical activity (PA) on a composite score for fracture risk in pre-pubertal children. Low PA in children is related to the composite score for fracture risk and the pre-pubertal years seem to be a period when PA positively affects the score. Introduction: This study evaluates if PA in children is related to clustering of risk factors for fracture. Research questions are the following: (i) What is the effect of physical activity (PA) on single traits and a composite score for fracture risk? (ii) Could this score be used to identify the level of PA needed to reach beneficial effects? Methods: This prospective population-based study included 269 children, aged 7–9 years at baseline while 246 attended the 2-year follow-up. We estimated duration of PA by questionnaires and measured traits that independently predict fractures. We then calculated gender specific Z-scores for each variable. The mean Z-score of all traits was used as a composite score for fracture risk. We tested correlation between duration of PA, each trait, and the composite score and group differences between children in different quartiles of PA. Results: At baseline, we found no correlation between duration of PA and any of the traits or the composite score. At follow-up, we found a correlation between PA and the composite score. Physical activity had an effect on composite score, and children in the lowest quartiles of PA had unbeneficial composite score compared to children in the other quartiles. Conclusion: Low PA in children is related to clustering of risk factors for fracture, and the pre-pubertal years seem to be a period when PA positively affects the composite score.
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| 3. |
- Larsson, Jonas, 1968-, et al.
(författare)
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Cardiovascular Effects of Load Carriage in Soldiers; A Pilot Study
- 2019
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Ingår i: Book of Abstracts of the 24th Annual Congress of the European College of Sport Science – 3rd - 6th July 2019, Prague – Czech Republic. - : European College of Sport Science. - 9783981841428 ; , s. 422-423
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Konferensbidrag (refereegranskat)abstract
- Introduction: Previous studies have shown that risk of physical fatigue increases if prolonged average work intensity exceeds 50% of oxygen uptake (VO2). In order to avoid persistent fatigue in a work setting, it is important to conduct suitable work capacity analyses. In physically demanding jobs where wearing protective gear and/or external load is mandatory, monitoring of cardiovascular demands through heart rate (HR) is one way to track the workers’ relative effort. There are limited studies examining effects of load carrying on cardiovascular capacity where it appears that VO2peak differ when soldiers and firefighters are tested with work-related equipment/clothing compared to light clothing. The aim of this pilot study was to investigate effects of load (combat gear) on HR, VO2 and muscle oxygen saturation (SmO2) compared to no load in soldiers during a graded treadmill protocol.Methods: Eight volunteer army soldiers (1 woman, 7 men) performed a graded treadmill test until exhaustion. All soldiers performed the test twice, once with light clothes and no load (NL) and once with added load, their personal combat gear (CG), with at least 48 h between sessions. The treadmill protocol stages included supine and standing positions, followed by marching speeds of 5.4 km/h and 8 km/h at 0 incline (all 5 min) immediately followed by a set marching speed of 8 km/h with a starting incline of 2 % increasing the incline 2 % every third minute until voluntary exhaustion. Measurements of HR, VO2 and SmO2 were collected continuously and the last 30 s of each stage were averaged and used for statistical analyses (paired t-tests).Results: The mean added load for all soldiers with CG was 16.8 ± 1.1 kg. All soldiers completed at least 6 stages (range 6-11 stages) with both NL and CG, where time to exhaustion with NL was longer (19.1 ± 3.2 min) compared to CG (9.1 ± 2.9 min; p <0.01). Submaximal HR and VO2 were both significantly higher with CG compared to NL (at absolute intensities) at all marching speeds all soldiers completed (5.4 km/h 0 % grade - 8 km/h 4% grade; all p<0.05). For SmO2, marching with CG compared to NL resulted in increased muscle oxygen utilization, at submaximal stages 8 km/h 0% -4% grade (all p<0.05). For values at maximal effort the CG had a significantly lower VO2peak (3.7 ± 0.5 L/min) compared to NL (4.1 ± 0.6 L/min, p <0.01), whereas there was no difference in HRpeak or the lowest value of SmO2 between CG (193.1 ± 7.2 bpm; 42.4 ± 30.3%) and NL (195.4 ± 8.9 bpm; 47.0 ± 29.2%).Conclusions: This pilot study suggests that assessment of aerobic capacity in soldiers should be conducted with combat gear to help determine their actual work capacity during combat and other load carrying tasks. These results suggest that if soldiers’ work performance is determined without added load it overestimates their aerobic capacity (VO2peak) in tasks wearing combat gear, which might lead to added fatigability and deleterious effect on performance.
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| 4. |
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| 5. |
- Larsson, Jonas, 1968-, et al.
(författare)
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Self-rated physical work demands for ground combat soldiers
- 2018
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Ingår i: PES 2018 3rd International Conference on Physical Employment Standards, University of Portsmouth, United Kingdom, 17-19 July 2018. ; , s. 31-31
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Konferensbidrag (refereegranskat)abstract
- Introduction: Military tasks are physically demanding, and the ability to achieve and maintain the physical capacity required to perform all military tasks are important. Previous studies in other countries have identified the most physically demanding work tasks to be carrying, lifting heavy loads, and digging. The aim of the present study was to identify the most physically demanding work tasks for Swedish ground combat soldiers and to study gender differences in perceived difficulty of the tasks.Methods: Based on procedural documentation, field manuals and job analyses, a questionnaire was developed that defined 30 work tasks for ground combat soldiers. To assess face and content validity, an expert focus group was used. The questionnaire was distributed to 231 ground combat soldiers, 165 of whom responded (71.4%), rating the perceived physical strain of the identified work tasks.Results: Of the 30 item work tasks included in the survey, five were selected as the most physically demanding. Transport of wounded was rated as the most demanding task both for aerobic endurance and strength. Other highly demanding tasks for aerobic capacity were low/high crawl, dismounted attack in close country, urban and rough terrain, and carrying heavy loads. For muscle strength demands there were a total of 11 different work task ranked for hand-, arm-, leg-, and core strength although many of them only occurred in one of the areas of interest. Carrying heavy loads were ranked in second place except for leg and core strength there it was in third place, instead high and low crawl was ranked very strenuous for leg and core strength. Care of wounded were ranked high for hand strength but not so hard for the rest of the areas.Conclusions: Swedish ground combat soldiers rate many tasks as physically demanding. Almost all the identified tasks were physically challenging and contains elements of lifting and carrying, which demand personnel’s muscular strength and muscular endurance capabilities for the soldiers. There were no significant differences in ranked physical requirements between male and female soldiers although they sometimes ranked the tasks in different order.
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| 6. |
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| 7. |
- Lopez, A. Garcia, et al.
(författare)
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Validation of SenseWear Armband in children, adolescents, and adults
- 2018
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 28:2, s. 487-495
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Tidskriftsartikel (refereegranskat)abstract
- SenseWear Armband (SW) is a multisensor monitor to assess physical activity and energy expenditure. Its prediction algorithms have been updated periodically. The aim was to validate SW in children, adolescents, and adults. The most recent SW algorithm 5.2 (SW5.2) and the previous version 2.2 (SW2.2) were evaluated for estimation of energy expenditure during semi-structured activities in 35 children, 31 adolescents, and 36 adults with indirect calorimetry as reference. Energy expenditure estimated from waist-worn ActiGraph GT3X+ data (AG) was used for comparison. Improvements in measurement errors were demonstrated with SW5.2 compared to SW2.2, especially in children and for biking. The overall mean absolute percent error with SW5.2 was 24% in children, 23% in adolescents, and 20% in adults. The error was larger for sitting and standing (23%-32%) and for basketball and biking (19%-35%), compared to walking and running (8%-20%). The overall mean absolute error with AG was 28% in children, 22% in adolescents, and 28% in adults. The absolute percent error for biking was 32%-74% with AG. In general, SW and AG underestimated energy expenditure. However, both methods demonstrated a proportional bias, with increasing underestimation for increasing energy expenditure level, in addition to the large individual error. SW provides measures of energy expenditure level with similar accuracy in children, adolescents, and adults with the improvements in the updated algorithms. Although SW captures biking better than AG, these methods share remaining measurements errors requiring further improvements for accurate measures of physical activity and energy expenditure in clinical and epidemiological research.
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| 8. |
- Soriano-Vidal, F. J., et al.
(författare)
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The Spanish version of the Childbirth Experience Questionnaire (CEQ-E): Reliability and validity assessment
- 2016
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Ingår i: BMC Pregnancy and Childbirth. - : Springer Science and Business Media LLC. - 1471-2393. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- © 2016 The Author(s).Background: The Childbirth Experience Questionnaire (CEQ) was originally designed to study women's perceptions of labour and birth. The main objective of our study was to adapt the CEQ to the Spanish context and determine its psychometric properties. This would provide an opportunity to evaluate women's experiences in order to improve evidence in the Spanish context as recommended by national guidelines. Methods: The CEQ was translated into Spanish using a standard forward and back translation method (CEQ-E). A convenience sample of 364 women was recruited from 3 Spanish hospitals; all participants were able to read and write in Spanish. Mothers with high risk pregnancies or preterm deliveries were excluded from the study. A self-administered questionnaire on sociodemographic variables was completed by participants before discharge. Data on childbirth variables were obtained from maternity records. Between 1 and 3 months postpartum a postal CEQ-E questionnaire was sent. The CEQ-E structure was examined by a confirmatory factor analysis of polychoric correlations using a diagonally weighted least squares estimator. Reliability was assessed using Cronbach's alpha. Construct validity was conducted by testing differences in CEQ-E scores between known-groups (to differ on key variables). Results: 226 (62.1%) of the recruited participants completed the postal questionnaire. The CEQ-E factor structure was similar to the original one. The Spanish version showed fit statistics in line with standard recommendations: CFI = 0.97; NNFI = 0.97; RMSEA = 0.066; SRMS = 0.077. The internal consistency reliability of the CEQ-E was good for the overall scale (0.88) and for all subscales (0.80, 0.90, 0.76, 0.68 for "own capacity", "professional support", "perceived safety" and "participation", respectively) and similar to the original version. Women with a labour duration ≤ 12 h, women with a labour not induced, women with a normal birth and multiparous women showed higher overall CEQ-E scores and "perceived safety" subscale scores. Women with a labour duration ≤ 12 h and those with previous experience of labour obtained higher scores for the "own capacity" and "participation" subscales. Conclusions: The results of this study indicate that the CEQ-E can be considered a valid and reliable measure of women's perceptions of labour and birth in Spain.
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| 9. |
- Thomsen, M., et al.
(författare)
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The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice
- 2017
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Ingår i: Pharmacology Biochemistry and Behavior. - : Elsevier BV. - 0091-3057. ; 160, s. 14-20
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Tidskriftsartikel (refereegranskat)abstract
- Glucagon-like peptide-1 (GLP-1) is a gut peptide that regulates food intake and glucose metabolism. GLP-1 is also produced and released in the brain, and GLP-1 receptors are expressed in brain regions important for alcohol and drug reward, and for the development of addiction. GLP-1 receptor agonists can decrease alcohol intake acutely in rodents. However, alcohol use disorder is a chronic condition that requires treatments to be effective in promoting abstinence from excessive alcohol consumption over time. Here, we assessed the effect of daily treatment with the GLP-1 receptor agonist Exendin-4 in an assay of relapse-like drinking in socially housed mice. Male C57BL/6NTac mice were allowed continuous access to alcohol without tastant in the home cage for 37 days. Then, alcohol bottles were removed and Exendin-4 (1.5 μg/kg/day) or saline was administered subcutaneously for 8 days during alcohol deprivation. Treatment continued for 8 additional days after reintroducing access to alcohol. A high-precision automated fluid consumption system was used to monitor intake of alcohol and water, drinking kinetics, and locomotor activity. Exendin-4 prevented the deprivation-induced increase in alcohol intake observed in control mice, without significantly affecting total fluid intake, body weight, or locomotor activity. The reduced alcohol intake was caused by a protracted latency to the first drink of alcohol and a reduced number of drinking bouts, while bout size and duration were not affected. The effect was maintained undiminished throughout the treatment period. These findings support the possible use of GLP-1 receptor agonists in the treatment of alcohol use disorder. © 2017 Elsevier Inc.
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