| 1. |
- Landén, Mikael, 1966, et al.
(författare)
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Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: a comparison of buspirone, nefazodone and placebo.
- 2001
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Ingår i: Psychopharmacology. - 0033-3158. ; 155:3, s. 292-8
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE: It is well established that serotonin reuptake inhibitors (SRIs) are effective for the treatment of premenstrual dysphoria (PMD), but the receptor subtype(s) mediating this effect of serotonin have yet not been identified. OBJECTIVE: In this trial, the possible efficacy of buspirone, a partial 5HT1A receptor agonist, and nefazodone, a combined SRI and 5HT2 receptor antagonist, was evaluated in women with PMD. METHODS: After a three-menstrual-cycle screening phase, patients were randomised to buspirone (n=19), nefazodone (n=22) or placebo (n=22). During the first two treatment cycles, patients were taking the drug during the luteal phase only (mean +/- SD daily dose of buspirone: 21 +/- 6 mg; nefazodone: 228 +/- 54 mg). During the subsequent two cycles, the medication was taken each day of the menstrual cycle (mean daily dose of buspirone: 27 +/- 10 mg; nefazodone: 304 +/- 95 mg). RESULTS: With respect to self-rated global improvement, buspirone (P<0.001) but not nefazodone was significantly superior to placebo. While buspirone appeared to reduce self-rated irritability (visual analogue scale) more effectively than placebo, other self-rated symptoms did not differ markedly between the groups. The side-effects were mild, and sexual dysfunction was not significantly more common in patients given buspirone or nefazodone than in those given placebo. CONCLUSION: It is suggested that buspirone is mildly effective for premenstrual irritability. In patients experiencing sexual dysfunction when treated with an SRI, buspirone may be a useful alternative.
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| 2. |
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| 3. |
- Liu, Wei, et al.
(författare)
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High frequency measurements and simulations of SiC MESFETs up to 250 degrees C
- 2004
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Ingår i: Materials Science Forum. - ZURICH-UETIKON : Trans Tech Publications Inc.. - 0255-5476 .- 1662-9752. ; 457-460, s. 1209-1212
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Tidskriftsartikel (refereegranskat)abstract
- 4H-SiC metal-semiconductor field effect transistors (MESFETs) [1] were characterized at 25, 100, 150, 200, and 250 degreesC and two-dimensional electro-thermal simulations [2] were performed to examine the effects of elevated device operating temperature and self-heating on DC and RF performance of the MESFETs. The gate and drain characteristics (I-d-V-g & I-d-V-d) were measured at room and elevated temperatures. The threshold voltage decreased with temperature and drain voltage. The shift of the threshold voltage was more prominent at low temperatures (2 V from 25 to 100 degreesC) than at high temperatures (negligible shift above 150 degreesC). No short channel effects could be seen in drain characteristics due to the self-heating effects. The measured drain saturation current decreases with increase temperature. At lower gate and drain voltages the measured drain current at room temperature is smaller than the drain current at elevated temperatures. The threshold voltage shift and the lower drain current at room temperature are believed to be caused by the substrate traps, which induce extra charges at the channel-buffer interface acting as a backside gate. The current gain and power gain were measured as a function of frequency. Decrease of f(T) and f(max) with increase of temperature was observed for both measurements and simulations. Higher fT and f(max) were obtained from simulations than from the measurements. Traps and parasitics are believed to be the cause for the differences. A strong influence of contact resistance was seen on f(T) and f(max) in the HF simulations.
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| 4. |
- Melke, Jonas, 1971, et al.
(författare)
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Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria.
- 2003
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Ingår i: Psychoneuroendocrinology. - 0306-4530. ; 28:3, s. 446-58
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to investigate if women with premenstrual dysphoria differ from controls with respect to the number of platelet serotonin transporters, and with respect to three polymorphisms in the gene coding for the serotonin transporter: a 44 base pair insertion/deletion in the promoter region, a variable number of tandem repeats in the second intron, and a single nucleotide polymorphism in the 3' untranslated region. Also, the possible relationship between the three polymorphisms and platelet serotonin transporter density was analyzed. The density of platelet [(3)H]paroxetine binding sites was significantly lower in women with premenstrual dysphoria than in controls, but patients and controls did not differ with respect to allele or genotype frequency for any of the three polymorphisms examined. A significant association between the number of platelet serotonin transporters and the promoter polymorphism was observed, subjects being homozygous for the short (deletion) variant having higher platelet serotonin transporter density than subjects carrying the long (insertion) allele. The results support the assumption that serotonin-related psychiatric disorders-such as premenstrual dysphoria-may be associated with a reduction in platelet [(3)H]paroxetine binding, but argue against the notion that this reduction is due to certain variants of the serotonin transporter gene being more common in patients than in controls.
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| 5. |
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| 6. |
- Anderberg, B, et al.
(författare)
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The design of a 3 GHz thermionic RF-gun and energy filter for MAX-lab
- 2002
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 491:1-2, s. 307-313
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Tidskriftsartikel (refereegranskat)abstract
- A new pre-injector has been designed for the MAX-laboratory. It consists of an RF-gun and a magnetic energy filter. The newly designed RF-gun geometry will be operated at 3 GHz in the thermionic mode using a BaO cathode. The pre-injector will provide a 2.3 MeV electron beam in 3 ps micro pulses to a new injector system currently under construction. (C) 2002 Elsevier Science B.V. All rights reserved.
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| 7. |
- Andersson, Greger, et al.
(författare)
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Finns det en "evangelikal exegetik"?
- 2004
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I vilken mening kan vi idag tala om en "evangelikal" exegetik? Vad innebär det idag att bedriva exegetik utifrån en evangelikal utgångspunkt och teologi? Är evangelikal exegetik i själva verket ett uttryck för en svunnen tid och gamla polariseringar? Finns det idag nya fronter i bibelsynsfrågorna? Detta är några av de brännande frågor som behandlas av de åtta bidragsgivarna.
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| 8. |
- Andersson, Åke, et al.
(författare)
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An RF-gun-driven recirculated linac as injector and FEL driver
- 2000
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - 0167-5087. ; 445:1-3, s. 413-421
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Tidskriftsartikel (refereegranskat)
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| 9. |
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| 10. |
- Andersson, Åke, et al.
(författare)
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Status of the new injector for MAX-lab
- 2002
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Ingår i: 8th European Particle Accelerator Conference. ; , s. 772-774
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Konferensbidrag (refereegranskat)abstract
- The new injector for MAX-lab is built around two 125 MeV linacs [B. Anderberg, (2000)] equipped with SLED cavities [Z.D. Farkas, (1974)]. The electron beam is recirculated once to reach 500 MeV. A 2.3 MeV thermionic RF gun [B. Anderberg, (2000)] injects into the system. The RF-gun is put into operation and commissioning of the first linac is proceeding. Results from the thermionic RF-gun operation, linac commissioning and first beam operations are presented.
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