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Träfflista för sökning "WFRF:(Fernandez G) srt2:(1995-1999)"

Sökning: WFRF:(Fernandez G) > (1995-1999)

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1.
  • Richard, G., et al. (författare)
  • Multi Modal Verification for Teleservices and Security Applications (M2VTS)
  • 1999
  • Ingår i: IEEE International Conference on Multimedia Computing and Systems. - Los Alamitos : IEEE. - 0769502539 ; , s. 1061-1064
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper presents the European ACTS project M2VTS which stands for Multi Modal Verification for Teleservices and Security Applications. The primary goal of this project is to address the issue of secured access to local and centralised services in a multimedia environment. The main objective is to extend the scope of application of network-based services by adding novel and intelligent functionalities, enabled by automatic verification systems combining multimodal strategies (secured access based on speech, image or other information). The objectives of the project are also to show that limitations of individual technologies (speaker verification, frontal face authentication, profile identification,...) can be overcome by relying on multi-modal decisions (combination or fusion of these technologies).
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2.
  • Fernandez, JA, et al. (författare)
  • The population, magnitudes, and sizes of Jupiter family comets
  • 1999
  • Ingår i: ASTRONOMY AND ASTROPHYSICS. - : SPRINGER VERLAG. - 0004-6361. ; 352:1, s. 327-340
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • We analyze the sample of measured nuclear magnitudes of the observed Jupiter family (JF) comets (taken as those with orbital periods P < 20 years and Tisserand parameters T > 2). We find a tendency of the measured nuclear magnitudes to be fainter as JF co
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  • Mannervik, B, et al. (författare)
  • An evolutionary approach to the design of glutathione-linked enzymes
  • 1998
  • Ingår i: CHEMICO-BIOLOGICAL INTERACTIONS. - : ELSEVIER SCI IRELAND LTD. - 0009-2797. ; 112, s. 15-21
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Studies of protein structure provide information about principles of protein design that have come into play in natural evolution. This information can be exploited in the redesign of enzymes for novel functions. The glutathione-binding domain of glutathi
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6.
  • Perlmann, P, et al. (författare)
  • Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria
  • 1997
  • Ingår i: Infection and immunity. - : American Society for Microbiology. - 0019-9567 .- 1098-5522. ; 65:1, s. 116-121
  • Tidskriftsartikel (refereegranskat)abstract
    • Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this immunoglobulin isotype. In this study, we show that IgE elevation may also be seen in severe malaria without cerebral involvement and parallels an elevation of tumor necrosis factor alpha (TNF). IgE-containing serum from malaria immune donors was added to tissue culture plates coated with rabbit anti-human IgE antibodies or with P. falciparum antigen. IgE-anti-IgE complexes as well as antigen-binding IgE antibodies induced TNF release from peripheral blood mononuclear cells (PBMC). Nonmalaria control sera with no IgE elevation induced significantly less of this cytokine, and the TNF-inducing capacity of malaria sera was also strongly reduced by passing them over anti-IgE Sepharose columns. The cells giving rise to TNF were adherent PBMC. The release of this cytokine probably reflects cross-linking of their low-affinity receptors for IgE (CD23) by IgE-containing immune complexes known to give rise to monocyte activation via the NO transduction pathway. In line with this, adherent monocytic cells exposed to IgE complexes displayed increased expression of CD23. As the malaria sera contained IgG anti-IgE antibodies, such complexes probably also play a role in the induction of TNF in vivo. Overproduction of TNF is considered a major pathogenic mechanism responsible for fever and tissue lesions in P. falciparum malaria. This overproduction is generally assumed to reflect a direct stimulation of effector cells by certain parasite-derived toxins. Our results suggest that IgE elevation constitutes yet another important mechanism involved in excessive TNF induction in this disease.
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7.
  • Rakov, V. A., et al. (författare)
  • New insights into lightning processes gained from triggered-lightning experiments in Florida and Alabama
  • 1998
  • Ingår i: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 103:D12, s. 14117-14130
  • Tidskriftsartikel (refereegranskat)abstract
    • Analyses of electric and magnetic fields measured at distances from tens to hundreds of meters from the ground strike point of triggered lightning at Camp Blanding, Florida, and at 10 and 20 m at Fort McClellan, Alabama, in conjunction with currents measured at the lightning channel base and with optical observations, allow us to make new inferences on several aspects of the lightning discharge and additionally to verify the recently published “two-wave” mechanism of the lightning M component. At very close ranges (a few tens of meters or less) the time rate of change of the final portion of the dart leader electric field can be comparable to that of the return stroke. The variation of the close dart leader electric field change with distance is somewhat slower than the inverse proportionality predicted by the uniformly charged leader model, perhaps because of a decrease of leader charge density with decreasing height associated with an incomplete development of the corona sheath at the bottom of the channel. There is a positive linear correlation between the leader electric field change at close range and the succeeding return stroke current peak at the channel base. The formation of each step of a dart-stepped leader is associated with a charge of a few millicoulombs and a current of a few kiloamperes. In an altitude-triggered lightning the downward negative leader of the bidirectional leader system and the resulting return stroke serve to provide a relatively low-impedance connection between the upward moving positive leader tip and the ground, the processes that follow likely being similar to those in classical triggered lightning. Lightning appears to be able to reduce, via breakdown processes in the soil and on the ground surface, the grounding impedance which it initially encounters at the strike point, so at the time of channel-base current peak the reduced grounding impedance is always much lower than the equivalent impedance of the channel. At close ranges the measured M-component magnetic fields have waveshapes that are similar to those of the channel-base currents, whereas the measured M-component electric fields have waveforms that appear to be the time derivatives of the channel-base current waveforms, in further confirmation of the “two-wave” M-component mechanism.
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  • Sikut, R, et al. (författare)
  • Detection of CD43 (leukosialin) in colon adenoma and adenocarcinoma by novel monoclonal antibodies against its intracellular domain.
  • 1999
  • Ingår i: International journal of cancer. Journal international du cancer. - 0020-7136. ; 82:1, s. 52-8
  • Tidskriftsartikel (refereegranskat)abstract
    • CD43 is a leukocyte-associated sialoglycoprotein which is also expressed in human colon adenoma and carcinoma. To obtain monoclonal antibodies (MAbs) that would react with CD43 in a glycosylation-independent way, antibodies were raised against a peptide corresponding to a portion of the CD43 cytoplasmic domain. Hybridomas were screened on paraffin sections from CD43-positive colon tumours. The reactivity of the antibodies with CD43 was verified by Western blot analysis of lysate of CHO cells transfected with human CD43 cDNA and by immunoprecipitation of lysates from CD43+ cell lines. Epitope mapping of antibodies was done using overlapping heptameric peptides. A detailed characterisation of one of the novel antibodies (CD43-3A1) is presented. This antibody reacts with the CD43 protein regardless of its glycosylation in Western blot analysis, immunoprecipitation and immuno-histochemistry of paraffin sections. Immuno-histochemical analysis of paraffin sections from colon adenoma and carcinoma tissues as well as colon cancer cell lines revealed that CD43 was predominantly localised intracellularly, in contrast to leukocyte-type cells. The MAb reacted more efficiently with paraffin-embedded colon adenoma and carcinoma cells than previously characterised CD43-specific antibodies. This should facilitate the evaluation of a potential role of CD43 during cancer development.
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