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- Allvin, Kerstin, 1970, et al.
(författare)
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Elevated serum levels of estradiol, dihydrotestosterone, and inhibin B in adult males born small for gestational age
- 2008
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Ingår i: Journal of Clinical Endocrinology & Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 93:4, s. 1464-9
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Prenatal growth restriction may affect future fertility in both females and males. Studies have shown that growth-retarded male rats have different sexual behavior and disturbed steroidogenesis. OBJECTIVE: We hypothesized that adult human males born small for gestational age (SGA) have an altered sex hormone profile. DESIGN, SETTING, AND PATIENTS: Twenty-five adult males born SGA with median birth weight -2.2 sd scores (SDS) and birth length -2.4 SDS were studied. Median age was 23.1 yr and final height -0.5 SDS. They were compared with 44 male controls with median age 20.5 yr and final height 0.4 SDS. MAIN OUTCOME MEASURE: The primary outcome before the study started was 17beta-estradiol (E(2)) levels in SGA males. RESULTS: The SGA group showed significantly higher median levels of E(2), 17.9 pg/ml (P < 0.001), and dihydrotestosterone (DHT), 0.543 ng/ml (P < 0.05), compared with controls, 12.6 pg/ml and 0.423 ng/ml, respectively. Testosterone (T) levels did not differ between groups. E(2) to T ratio correlated negatively to birth weight (r = -0.40, P < 0.01) and birth length (r = -0.44, P < 0.001). DHT to T ratio correlated negatively to birth weight (r = -0.51, P < 0.001) and birth length (r = -0.38, P < 0.01). Males born SGA also had significantly higher median levels of inhibin B, 164 pg/ml (P < 0.05), compared with controls, 137 pg/ml. Inhibin B correlated negatively to birth length (r = -0.34, P < 0.01). CONCLUSION: SGA males of normal stature have higher levels of E(2), DHT, and inhibin B than controls, indicating a disturbed steroid synthesis or metabolism. Aromatase activity, calculated as E(2) to T ratio, and 5alpha-reductase activity, calculated as DHT to T ratio, is negatively correlated to size at birth.
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| 2. |
- Fors, Carina, 1978-, et al.
(författare)
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Online Laser Doppler Measurements of Myocardial Perfusion
- 2008
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Ingår i: IFMBE Proceedings 22,2008. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783540892076 - 9783540892083 ; , s. 1718-1721
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Konferensbidrag (refereegranskat)abstract
- Laser Doppler perfusion monitoring is a suitable method for microvascular blood perfusion measurements. When used on a moving tissue or organ, the Doppler signal arising from the moving blood cells may be distorted. ECG triggering of the laser Doppler signal can be used for reducing the influence from movements during measurements on the beating heart. The aim of this study was to determine the most appropriate triggering intervals during the cardiac cycle for online measurements. Recordings from thirteen coronary artery bypass graft (CABG) patients were included in the study. During surgery, the fibre-optic probe was passed through the chest wall and sutured to the left anterior ventricular wall with the probe tip inserted 3–5 mm into the myocardium. After the patient arrived at the intensive care unit a second measurement was initiated and lasted for about two hours. Before the probe was removed a third measurement was performed for about 5 minutes the following morning. A total of 97 data sequences were analysed and the intervals of low and stable perfusion signal were compared to the positions of the T and P peaks in the ECG.It was found that the most appropriate time intervals were in late systole at the T peak [−3, 9] ms and just before the P peak [−28, -10] ms in late diastole. However, the position of these intervals may vary between individuals, because of e.g., abnormal cardiac motion. With the use of the appropriate interval online measurement of the myocardial perfusion on a beating heart appears possible.
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| 3. |
- Kircher, Katja, et al.
(författare)
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Fokus på halka : fokusgruppsresultat om attityder kring framtida halkinformationssystem
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SRIS (Slippery Road Information System) is a Swedish project that will be accomplished during 2006-2008. The project aims to develop a system to evaluate winter road conditions in real-time. Information about the road condition is received both from the road weather information stations that are located along the roads and from ordinary vehicles running on the roads. The road friction is estimated from the vehicle's existing sensors and the information is sent to a central unit that merges all information and calculates a low friction index, which is presented on a web page. Further development of the system could make it possible to send information about low friction to drivers, when they are driving. Information about slipperiness could potentially also be useful for the winter maintenance workforce. In order to investigate professional drivers' and winter maintenance workers' attitudes towards slippery road information systems, two focus groups were conducted. Five winter maintenance workers participated in the first focus group, while the second group consisted of eight professional drivers of heavy vehicles.
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