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- Narod, SA, et al.
(författare)
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Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
- 2002
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105. ; 94:23, s. 1773-1779
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Tidskriftsartikel (refereegranskat)abstract
- Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1 and/or BRCA2 mutations recruited from 52 centers in 11 countries. Women who had been diagnosed with breast cancer were matched to control subjects by year of birth, country of residence, mutation (BRCA1 or BRCA2), and history of ovarian cancer. All study subjects completed a questionnaire about oral contraceptive use. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived by conditional logistic regression. All statistical tests were two-sided. Results: Among BRCA2 mutation carriers, ever use of oral contraceptives was not associated with an increased risk of breast cancer (OR = 0.94, 95% CI = 0.72 to 1.24). For BRCAI mutation carriers, ever use of oral contraceptives was associated With a modestly increased risk of breast cancer (OR = 1.20, 95 % CI = 1.02 to 1.40). However, compared with BRCA1 mutation carriers who never used oral contraceptives, those who used oral contraceptives for at least 5 years had an increased risk of breast cancer (OR = 1.33, 95% CI = 1.11 to 1.60), as did those who used oral contraceptives before age 30 (OR = 1.29, 95% CI = 1.09 to 1.52), those who were diagnosed with breast cancer before age 40 (OR = 1.38, 95% CI = 1.11 to 1.72), and those who first used oral contraceptives before 1975 (OR = 1.42, 95 % CI = 1.17 to 1.75). Conclusions: Among BRCA1 mutation carriers, women who first used oral contraceptives before 1975, who used them before age 30, or who used them for 5 or more years may have an increased risk of early-onset breast cancer. Oral contraceptives do not appear to be associated with risk of breast cancer in BRCA2 carriers, but data for BRCA2 carriers are limited.
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| 3. |
- Garber, Nicholas J, et al.
(författare)
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Distribution and characteristics of crashes at different locations within work zones in Virginia
- 2001
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Ingår i: Proceedings of the Conference Road Safety on Three Continents in Pretoria, South Africa, 20-22 September 2000. - Linköping : Statens väg- och transportforskningsinstitut. ; , s. 473-498
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Work zones tend to cause hazardous conditions for vehicle drivers and construction workers since these work zones generate conflicts between construction activities and the traffic, and therefore aggravate the existing traffic conditions. This study investigated the characteristics of work zone crashes in Virginia that occurred between 1996 and 1999. The information on each crash was obtained from the police crash records. Each crash was located in one of five areas of the work zone: 1) advance warning area; 2) transition area; 3) longitudinal buffer area; 4) activity area; and 5) termination area. An analysis of the percentage distributions was then carried out, with respect to the locations of the crashes, the severity, collision types and different types of highways. The proportionality test was used to determine significant differences at the 5% significance level. The results indicate that the Activity Area (Area 4) is the predominant location for work zone crashes regardless of the highway type, and that rear-end crashes are the predominant type of crashes. However, the results also indicated that the proportion of the sideswipe in same direction (SS) crashes in the Transition Area (area 2) is significantly higher than that in the Advance Warning Area (Area 1).
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