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A randomized, doubl...
A randomized, double-blind, placebo-controlled trial of camicinal in Parkinson's disease.
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Marrinan, Sarah L (författare)
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Otiker, Tal (författare)
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Vasist, Lakshmi S (författare)
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visa fler...
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Gibson, Rachel A (författare)
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Sarai, Bhopinder K (författare)
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Barton, Matthew E (författare)
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Richards, Duncan B (författare)
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- Hellström, Per M., 1954- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Nyholm, Dag (författare)
- Uppsala universitet,Neurologi
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Dukes, George E (författare)
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Burn, David J (författare)
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(creator_code:org_t)
- 2017-12-26
- 2018
- Engelska.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 33:2, s. 329-332
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Delayed gastric emptying may impair l-dopa absorption, contributing to motor fluctuations. We evaluated the effect of camicinal (GSK962040), a gastroprokinetic, on the absorption of l-dopa and symptoms of PD.METHODS: Phase II, double-blind, placebo-controlled trial. Participants were randomized to receive camicinal 50 mg once-daily (n = 38) or placebo (n = 20) for 7 to 9 days.RESULTS: l-dopa exposure was similar with coadministration of camicinal compared to placebo. Median time to maximum l-dopa concentration was reduced, indicating more rapid absorption of l-dopa. Camicinal resulted in significant reduction in OFF time (-2.31 hours; 95% confidence interval: -3.71, -0.90), significant increase in ON time (+1.88 hours; 95% confidence interval: 0.28, 3.48) per day, and significant decrease in mean total MDS-UPDRS score (-12.5; 95% confidence interval: -19.67, -5.29). Camicinal treatment was generally well tolerated.CONCLUSIONS: PD symptom improvement with camicinal occurred in parallel with more rapid absorption of l-dopa. This study provides evidence of an improvement of the motor response to l-dopa in people with PD treated with camicinal 50 mg once-daily compared with placebo, which will require further evaluation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Clinical trials Randomized controlled (CONSORT agreement)
- Parkinson's disease/parkinsonism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Marrinan, Sarah ...
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Otiker, Tal
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Vasist, Lakshmi ...
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Gibson, Rachel A
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Sarai, Bhopinder ...
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Barton, Matthew ...
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visa fler...
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Richards, Duncan ...
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Hellström, Per M ...
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Nyholm, Dag
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Dukes, George E
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Burn, David J
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Movement Disorde ...
- Av lärosätet
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Uppsala universitet