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Computed tomography...
Computed tomography of experimental liver metastases using an iodinated hepatocyte-specific lipid emulsion : a correlative study in the nude rat
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- Sundín, Anders (författare)
- Uppsala universitet,Enheten för radiologi
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Graf, Wilhelm (författare)
- Uppsala universitet,Kolorektalkirurgi
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visa fler...
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- Magnusson, Anders (författare)
- Uppsala universitet,Enheten för radiologi
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visa färre...
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(creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: Investigative Radiology. - 0020-9996 .- 1536-0210. ; 29:11, s. 963-969
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- RATIONALE AND OBJECTIVES: A hepatocyte-specific iodinated lipid emulsion, NRI 757, was used for detection of experimental hepatic metastases. MATERIALS AND METHODS: The study was performed in a correlative model of multiple hepatic metastases from a human colonic cancer implanted in the nude rat. RESULTS: After intravenous injection, normal liver parenchyma remained enhanced for several hours, whereas the uptake in hepatic metastases was negligible. A liver-to-lesion contrast of 45 Hounsfield units (HU) was obtained at a dose of 1 mL NRI 757/kg body weight (BW). In a lesion-by-lesion analysis of 177 metastases ranging in size from 1 to 32 mm, the mean +/- standard deviation overall detection rate for native scanning and contrast-enhanced scanning in vivo and post mortem, 20 +/- 0.4%, 53 +/- 5.2%, and 55 +/- 4.0%, respectively and 28%, 84%, and 82%, retrospectively. When metastatic size also was considered, for native scanning the maximum detection rate of 61% was reached for 8- to 10-mm lesions, whereas for contrast-enhanced computed tomography scanning, 100% of the 5- to 7-mm lesions and 42% of the 1- to 2-mm nodules were detected. CONCLUSION: The use of NRI 757 improved the diagnostic yield considerably.
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