| 1. |
- Akimov, D., et al.
(författare)
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Physics with WASA and PROMICE
- 1994
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Ingår i: Physics with GeV-particle beams, Juelich 1994. ; , s. 519-530
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Konferensbidrag (refereegranskat)
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| 2. |
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| 3. |
- Calén, H., et al.
(författare)
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Deuteron breakup by 1.15 GeV protons and excitation of the Δ isobar
- 1993
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 303:1-2, s. 10-15
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Tidskriftsartikel (refereegranskat)abstract
- The pd→npp reaction has been measured using circulating 1.15 GeV protons, a gas jet target and scintillation detectors selecting scattered protons with energy above 30 MeV. The distribution of the two-proton invariant mass has a maximum at 2.13 ± 0.01 GeV/c2 and a width of 130 ± 10 MeV/c2 (FWHM). We see no evidence of narrow (Γ < 30 MeV/c2) peaks in the phase-space region selected. The mass of X, excited in the pN→nX elementary process, is 40 MeV/c2 smaller than the mass of a real Δ isobar.
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| 4. |
- Calén, H, et al.
(författare)
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Deuteron breakup in the Δ-isobar region
- 1993
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Ingår i: Physica Scripta. - : Institute of Physics (IOP). - 0031-8949 .- 1402-4896. ; 48:1, s. 86-91
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Tidskriftsartikel (refereegranskat)abstract
- The pd → npp charge exchange reaction has been studied at 1.15 GeV incident proton energy in a selected kinematical region. The distributions of two-proton invariant mass Mpp, of angle of a single proton and the differential cross section dσ/dt of the (p, n) reaction are presented and compared with model predictions corrected for the acceptance of the experimental apparatus. We see no evidence of narrow (Γ < 30 MeV/c2) peaks in the Mpp interval 2.1-2.3 GeV/c2. The production of an intermediate Δ isobar in the primary (p, n) charge exchange and its subsequent absorption in a final state ΔN → pp process together with the background from quasi-free charge exchange scattering reasonably reproduces the general trends of the data.
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| 5. |
- Calen, H., et al.
(författare)
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Status of the CELSIUS and WASA projects
- 1990
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Ingår i: Gif-sur-Yvette 1990, Proceedings, Rare decays of light mesons. ; , s. 187-197
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Konferensbidrag (refereegranskat)
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| 6. |
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| 7. |
- Franzén, Lars, et al.
(författare)
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Fractionated-irradiation and late changes in rat parotid-gland : effects on the number of acinar-cells, potassium efflux, and amylase secretion
- 1993
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Ingår i: International Journal of Radiation Biology. - : Informa UK Limited. - 0955-3002 .- 1362-3095. ; 64:1, s. 93-101
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Tidskriftsartikel (refereegranskat)abstract
- Irradiation of head- and neck cancer commonly results in oral dryness and discomfort for the patients due to salivary gland damage. The exact mechanisms behind the inherent radiosensitivity of salivary glands remain to be elucidated. In the present study, we used different in vitro secretory models and quantitative morphological characterization of rat parotid gland following fractionated unilateral irradiation to one gland on a 5-day fraction schedule (Monday-Friday) with 6 MV photons (total dose 30, 35, 40 and 45 Gy) or a two-fractions regimen in 5 days (Monday and Friday) with total dose of 24 and 32 Gy. The contralateral shielded gland served as control, and parallel analyses of irradiated and control glands were performed 180 days following the last irradiation treatment. The relative noradrenaline stimulated electrolyte secretion (rubidium-86 tracer for potassium) was decreased in the irradiated compared with control glands. The noradrenaline-stimulated exocytotic amylase release was not significantly affected by irradiation, but the gland content of amylase was decreased dose-dependently. The quantitative morphological analysis revealed a dose-dependent decline in the number of acinar cells, whereas the other parenchymal cells (intercalated, striated- and excretory duct cells) were un-, affected by the irradiation compared with control glands.
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| 8. |
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| 9. |
- Henriksson, R, et al.
(författare)
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Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity
- 1994
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Ingår i: British Journal of Cancer. - 1532-1827. ; 69:2, s. 320-326
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Tidskriftsartikel (refereegranskat)abstract
- The detailed mechanisms which can explain the inherent radiosensitivity of salivary glands remain to be elucidated. Although DNA is the most plausible critical target for the lethal effects of irradiation, interactions with other constituents, such as cell membrane and neuropeptides, have been suggested to cause important physiological changes. Moreover, mast cells seem to be closely linked to radiation-induced pneumonitis. Therefore, in the present study the effects of fractionated irradiation on salivary glands have been assessed with special regard to the appearance of mast cells and its correlation with damage to gland parenchyma. Sprague-Dawley strain rats were unilaterally irradiated to the head and neck with the salivary glands within the radiation field. The irradiation was delivered once daily for 5 days to a total dose of 20, 35 and 45 Gy. The contralateral parotid and submandibular glands served as intra-animal controls and parallel analysis of glands was performed 2, 4, 10 or 180 days following the last radiation treatment. Morphological analysis revealed no obvious changes up to 10 days after the irradiation. At 180 days a radiation dose-dependent loss of gland parenchyma was seen, especially with regard to serious acinar cells in parotid gland and acinar cells and serous CGT (convoluted granular tubule) cells in the submandibular gland. These changes displayed a close correlation with a concomitant dose-dependent enhanced density of mast cells and staining for hyaluronic acid. This cell population seems to conform with the features of the connective tissue mast cell type. The parotid seems to be more sensitive to irradiation than the submandibular gland. Thus, the present results further strengthen the role of and the potential interaction of mast cells with radiation-induced tissue injury and alterations in normal tissue integrity.
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| 10. |
- Rönnelid, J, et al.
(författare)
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Short-term kinetics of the humoral anti-C1q response in SLE using the ELISPOT method : fast decline in production in response to steroids.
- 1994
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Ingår i: Scandinavian Journal of Immunology. - 0300-9475 .- 1365-3083. ; 40:2, s. 243-250
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Tidskriftsartikel (refereegranskat)abstract
- Twenty four systemic lupus erythaematosus patients and 17 patients with other diagnoses were investigated regarding the presence of cells producing C1q reactive antibodies in peripheral blood mononuclear cells using the ELISPOT technique. These results were then compared with parallel serum levels of C1q reactive antibodies. Current production of anti-C1q was almost entirely confined to the systemic lupus erythaematosus group. Longitudinal analysis of anti-C1q ELISPOT positive patients showed rapid changes in the number of anti-C1q producing cells, but only slowly changing serum levels of the corresponding antibodies in response to glucocorticoids. In one systemic lupus erythaematosus patient prednisolone treatment had a selective effect on this autoantibody production, as the production of anti-C1q spot forming cells rapidly dropped to zero, at the same time as the number of total spot-forming cells showed only less change. In another patient, self-limiting connective tissue disease was associated with temporal occurrence of IgM anti-C1q. We believe, from these data, that the ELISPOT method for determination of current antibody production may be of particular value in longitudinal evaluation of disease course and therapeutic effects in systemic lupus erythaematosus and other rheumatic diseases.
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