| 1. |
- Lindvall, O, et al.
(författare)
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Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease
- 1994
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Ingår i: Annals of Neurology. - : Wiley. - 0364-5134. ; 35:2, s. 80-172
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Tidskriftsartikel (refereegranskat)abstract
- Two patients with idiopathic Parkinson's disease (Patients 3 and 4 in our series) were followed up to 3 years after grafting of human embryonic dopamine-rich mesencephalic tissue unilaterally into the putamen. During the first postoperative year both patients showed significant amelioration of parkinsonian symptoms and increased 6-L-[18F]-fluorodopa uptake in the grafted putamen, as assessed with positron emission tomography. Three years after grafting the patients still exhibited increased fluorodopa uptake in the grafted putamen and significant clinical improvements, evidenced by a reduction of the severity of symptoms and of the time spent in the "off" phase, and by a prolongation of the effect of a single dose of L-dopa. Between 1 and 3 years after surgery, Patient 3 showed only minor changes of parkinsonian symptoms on the side contralateral to the graft, whereas there was a worsening on the ipsilateral side. Fluorodopa uptake decreased in the nongrafted putamen but was unchanged in the grafted putamen. Patient 4 continued to improve after the first postoperative year and L-dopa was withdrawn after 32 months. The reduction of parkinsonian symptoms on the side contralateral to the graft became more pronounced between 1 and 3 years after surgery. Fluorodopa uptake further increased in the grafted putamen, whereas no change was detected on the non-grafted side. These results indicate that grafts of embryonic dopamine neurons can survive, grow, and exert functional effects up to at least 3 years after surgery in the parkinsonian brain, despite an ongoing disease process leading to degeneration of the intrinsic dopamine system.
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| 2. |
- Olsson, Erik J, et al.
(författare)
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Pentium till lågpris
- 1994
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Ingår i: Maxidata. - 1102-7029. ; :2, s. 43-47
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 3. |
- Åström, Karl J., et al.
(författare)
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Facing the Challenge of Computer Science in the Industrial Applications of Control
- 1992
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Control, signal processing, and more generally "systems" industries ignore the boundaries we have in the academic world between control, signal processing, and computer sciences. Industries think of "hardware" (electronics or computers) and "software", making little distinction between algorithms development and implementation of them. Acting as a chariman of the IFAC Technical Committee on Theory for the triennium 1990-1993, Albert Benveniste proposed in the fall of 1989 this project to investigate some fundamental questions raised by the above mentioned facts. Since CDC'90 this has been approved as a joint IEEE/CSS-IFAC project managed by the above listed group of people. A detailed progress report of the project has been written in March 20, 1991, followed by a brief update in October 19, 1991. This is summary of the conclusions of the report. Additional detailed information on the project is found in the bibliography.
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