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Fracture incidence ...
Fracture incidence in GH-deficient patients on complete hormone replacement including GH
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- Holmer, Helene (author)
- Skåne University Hospital,Centralsjukhuset, Kristianstad, Sweden
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- Svensson, Johan (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Rylander, Lars (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Sweden
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- Johannsson, Gudmundur (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Rosén, Thord (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Bengtsson, Bengt-Åke (author)
- Sahlgrenska University Hospital, Göteborg, Sweden
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- Thorén, Marja (author)
- Karolinska University Hospital Solna, Stockholm, Sweden
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- Höybye, Charlotte (author)
- Karolinska University Hospital Solna, Stockholm, Sweden
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- Degerblad, Marie (author)
- Karolinska University Hospital Solna, Stockholm, Sweden
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- Bramnert, Margareta (author)
- Skåne University Hospital,University Hospital, Malmö, Sweden
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- Hägg, Erik (author)
- Umeå universitet,Medicin,University Hospital, Umeå, Sweden
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- Edén Engström, Britt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism,Uppsala University Hospital, Sweden
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- Ekman, Bertil, 1958- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Thorngren, Karl-Göran (author)
- University Hospital, Lund, Sweden
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- Hagmar, Lars (author)
- Lund University, Sweden
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- Erfurth, Eva-Marie (author)
- Skåne University Hospital,Lund University Hospital, Sweden
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(creator_code:org_t)
- 2007-08-27
- 2007
- English.
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In: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431 .- 1523-4681. ; 22:12, s. 1842-1850
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Fracture risk in GHD patients is not definitely established. Studying fracture incidence in 832 patients on GH therapy and 2581 matched population controls, we recorded a doubled fracture risk in CO GHD women, but a significantly lower fracture risk in AO GHD men. Introduction: The objective of this study was to evaluate fracture incidence in patients wilh confirmed growth hormone deficiency (GHD) on replacement therapy (including growth hormone [GH]) compared with population controls, while also taking potential confounders and effect modifiers into account. Materials and Methods: Eight hundred thirty-two patients with GHD and 2581 matched population controls answered a questionnaire about fractures and other background information. Incidence rate ratio (IRR) and 95% CI for first fracture were estimated. The median time on GH therapy for childhood onset (CO) GHD men and women was 15 and 12 yr, respectively, and 6 and 5 yr for adult onset (AO) GHD men and women, respectively. Results: A more than doubled risk (IRR, 2.29; 95% CI, 1.23-4.28) for nonosteoporotic fractures was recorded in women with CO GHD, whereas no risk increase was observed among CO GHD men (IRR. 0.61) and AO GHD women (IRR, 1.08). A significantly decreased incidence of fractures (IRR, 0.54; 95% CI 0.34-0.86) was recorded in AO GHD men. Conclusions: Increased fracture risk in CO GHD women can most likely be explained by interaction between oral estrogen and the GH-IGF-I axis. The adequate substitution rate of testosterone (90%) and GH (94%) may have resulted in significantly lower fracture risk in AO GHD men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Fracture incidence
- Growlh hormone deficiency
- Growth hormone therapy
- Pituitary deficiency
- Population study
- MEDICINE
- MEDICIN
- growth hormone therapy
- hormone deficiency
- growth
- pituitary deficiency
- population study
- fracture incidence
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Holmer, Helene
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Svensson, Johan
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Rylander, Lars
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Johannsson, Gudm ...
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Rosén, Thord
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Bengtsson, Bengt ...
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Thorén, Marja
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Höybye, Charlott ...
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Degerblad, Marie
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Bramnert, Margar ...
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Hägg, Erik
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Edén Engström, B ...
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Ekman, Bertil, 1 ...
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Thorngren, Karl- ...
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Hagmar, Lars
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Erfurth, Eva-Mar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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MEDICAL AND HEAL ...
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- Articles in the publication
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Journal of Bone ...
- By the university
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Uppsala University
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Umeå University
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Lund University
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Linköping University