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Träfflista för sökning "WFRF:(HELLGREN H) srt2:(2005-2009)"

Sökning: WFRF:(HELLGREN H) > (2005-2009)

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1.
  • Shin, J. H., et al. (författare)
  • IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5
  • 2007
  • Ingår i: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 503-12
  • Tidskriftsartikel (refereegranskat)abstract
    • In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.
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2.
  • Sedimbi, S. K., et al. (författare)
  • SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients
  • 2007
  • Ingår i: Genes Immun. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 8:6, s. 518-21
  • Tidskriftsartikel (refereegranskat)abstract
    • SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.
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3.
  • Lindehammer, Sabina, et al. (författare)
  • Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
  • 2008
  • Ingår i: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.
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4.
  • Sanjeevi, Carani B., et al. (författare)
  • The risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group are different in different regions of Sweden
  • 2008
  • Ingår i: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. - 9781573317337 ; 1150, s. 106-11
  • Tidskriftsartikel (refereegranskat)abstract
    • HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP. The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six geographical regions, subjects from Stockholm had the highest OR, followed by those from Lund, Linköping, Gothenburg, Umeå, and Uppsala. Absolute protection was conferred by the presence of DQ6 in subjects from the Linköping region, but varied in the other regions. The frequency of DR3 and DQ2, DR4 and DQ8, DR15, and DQ6 in patients showed high linkage for each region, but were different between regions. In conclusion: The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden. The results highlight the important role played by the various environmental factors in the precipitation of T1D.
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6.
  • Askling, Helena H, et al. (författare)
  • Serologic Analysis of Returned Travelers with Fever, Sweden
  • 2009
  • Ingår i: Emerging Infectious Diseases. - Atlanta, GA, USA : U.S. Department of Health and Human Services * Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 15:11, s. 1805-1808
  • Tidskriftsartikel (refereegranskat)abstract
    • We studied 1,432 febrile travelers from Sweden who had returned from malaria-endemic areas during March 2005-March 2008. In 383 patients, paired serum samples were blindly analyzed for influenza and 7 other agents. For 21% of 115 patients with fever of unknown origin, serologic analysis showed that influenza was the major cause.
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9.
  • Ritz, R, et al. (författare)
  • A new software center for the neuroinformatics community
  • 2008
  • Konferensbidrag (refereegranskat)abstract
    • The mission of the International Neuroinformatics Coordinating Facility is to coordinate and foster international activities in neuroinformatics. In general, this includes combining neuroscience and informatics research to develop and apply advanced tools and approaches essential for a major advancement in understanding the structure and function of the brain. There are a significant number of resources available for neuroscientists today, yet they are not used as widely as they should because discovering their existence and evaluating their quality and relevance remain tedious tasks. Furthermore, the development of such resources often relies on isolated laboratories where collaboration across projects would be beneficial. INCF has therefore created a Neuroinformatics Portal, and released a Software Center as its first component.
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10.
  • Sverke, Magnus, et al. (författare)
  • Job insecurity and absenteeism : Cross-lagged analysis
  • 2008
  • Ingår i: Paper presented at the 7th International Conference on Occupational Stress and Health, Washington, DC, March 5-8, 2008.
  • Konferensbidrag (populärvet., debatt m.m.)abstract
    • Job insecurity can be defined as a perceptual phenomenon, reflecting the fear of involuntary job loss. One important characteristic with respect to this worry about the future of the employment situation is that it is involuntary. Another distinguishing feature about job insecurity is that it concerns an uncertainty regarding future events. A growing number of studies, including a meta-analysis, have documented that job insecurity is related to job dissatisfaction, impaired organizational commitment, increased turnover intention, and physical as well as mental health complaints. There are also indications that the worry of job loss may be related to factors such as impaired compliance with safety procedures, ischemic heart disease occurrence, and absenteeism.However, most studies have been cross-sectional and therefore unable to control for initial levels of the outcome variables and examine temporal precedence. Only a few studies have explicitly addressed the issue of direction of relation between job insecurity and such outcomes. The aim of the present study is to shed light on the issue of causality in the relationship between job insecurity and potential outcomes that have attracted comparatively limited research attention – sickness absenteeism and presenteeism. Drawing upon the literature on work stress, it is reasonable to suggest that job insecurity, because of its associations with mental and somatic symptoms, may lead to increased absenteeism from work. Equally plausible, however, would be to assume that individuals with high absenteeism records would feel more at risk in organizations where there is a threat of layoffs. In terms of presenteeism, job insecurity may lead workers to feel a pressure to go to work even when they are unhealthy. In contrast, it may also be that sickness presenteeism is a way to show that one is valuable to the organization, as an attempt to minimize the risk of being seen as redundant in the future.Longitudinal questionnaire data collected among white-collar workers in a Swedish organization, with a one-year time interval, served as input to cross-lagged analysis. In an attempt to rule out the alternative hypothesis that job insecurity as well as absenteeism and presenteeism are caused by third variables, we controlled for factors such as demographics and well-being. Preliminary analyses reveal that job insecurity was positively associated with subsequent absenteeism, but not with presenteeism, and there was no support for reverse causality. The results suggest that absenteeism may be an important, albeit hitherto rather neglected, outcome of job insecurity, and contribute to the understanding of the development and consequences of job insecurity by shedding light on the issue of sickness absenteeism/presenteeism in this process.
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