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- Landin-Olsson, Mona, et al.
(författare)
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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls
- 1990
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Ingår i: Pancreas. - : Ovid Technologies (Wolters Kluwer Health). - 0885-3177. ; 5:3, s. 241-247
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.
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| 5. |
- Rigné, E.M., et al.
(författare)
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Child Sexual Abuse : A Study of Controversy and Construction
- 1994
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Ingår i: Acta Sociologica. - : SAGE Publications. - 0001-6993 .- 1502-3869. ; 37, s. 141-163
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we focus on the construction of and controversy surrounding child sexual abuse as a social problem in the Swedish context. Using concepts and approaches from the field of science studies, we investigate how the problem has been introduced to the public and by whom. We identify what we call a knowledge-based controversy. The frequency of child sexual abuse, the methods of diagnosing it, and the role of the investigator are highly disputed. It would appear that clinical child psychologists are especially engaged in this problem construction as well as in controversy with other professionals. Different strategies are chosen in order to increase professional legitimacy, and exclude others' claims to expertise on the subject. Our conclusion is that at present there is no indication that psychologists have reached a more comprehensive experience and/or unified knowledge of child sexual abuse than any competing professional group dealing with the issue.
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