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- Bekris, L. M., et al.
(författare)
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GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination
- 2007
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Ingår i: Diabetic Medicine. - : Wiley. - 1464-5491 .- 0742-3071. ; 24:5, s. 521-526
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Tidskriftsartikel (refereegranskat)abstract
- Aims Subcutaneous injection of recombinant human GAD65 (rhGAD65) in patients with latent autoimmune diabetes in adults (LADA) correlates with an increase in C-peptide levels. In this study we analysed the effect of rhGAD65 administration on the GAD65-specific autoimmune response. Methods Longitudinal serum samples obtained from LADA patients (n = 47) who received 4, 20, 100 or 500 mu g alum-formulated rhGAD65 or placebo by subcutaneous injection twice (4 weeks apart) were analysed for their epitope recognition using GAD65-specific recombinant Fab and GAD65/67 fusion proteins. Results Overall, minor changes in the epitope pattern were observed using either approach. Only in the 500-mu g dosage group was an increase in GAD65Ab level associated with a significant increase in the binding to a conformational epitope located at the middle part of GAD65. Conclusions Our data suggest that the apparent beneficial effects of 20 mu g alum-formulated recombinant human GAD65 is not explained by changes in the GAD65Ab epitope pattern.
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| 2. |
- Hampe, M., et al.
(författare)
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Transatlantic dual bachelor's degree programs between two European and an American university
- 2007
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Ingår i: 2007 ASEE Annual Conference and Exposition, Conference Proceedings. - : American Society for Engineering Education.
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Konferensbidrag (refereegranskat)abstract
- The ATLANTIS project joins the European Union and the United States of America in an unpreceded endeavor to foster international education on the undergraduate level. Technische Universität Darmstadt (TUD), Germany, Kungliga Tekniska Högskolan (KTH), Stockholm, Sweden, and Virginia Polytechnical Institute and State University (VT), Blacksburg, VA, will jointly establish Dual Bachelor of Science Programs in Mechanical Engineering between 2007 and 2010. The objective of the project is to produce highly competent graduates in the field of Mechanical Engineering (BSME) that are uniquely prepared to successfully engage and excel in the new global engineering economy. Another objective is to demonstrate that graduation is possible without delaying graduation to the extent that it delays the start of a consecutive master's program. Thus, the study program will be 4 years for students from Virginia Tech and 3 years and a few months for students from TUD and KTH. The language of instruction will be German for students staying at TUD, English for students staying at Virginia Tech, and Swedish or English for students staying at KTH. The program consists of two transatlantic dual BSME degree programs: VT-TUD and VT-KTH. The third combination TUD-KTH is basically an intra-European exchange and not considered here. The general model for these two dual degree programs is that (1) the students complete their introductory courses at their home universities; (2) they spend a summer at the third university that they will not receive a degree from; and (3) they spend their final year (senior) at the second university that they are receiving a degree from.
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