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- Yao, W-M, et al.
(författare)
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Review of Particle Physics
- 2006
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Ingår i: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 33:1, s. 1-1
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Tidskriftsartikel (refereegranskat)
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- Villa, Luisa L., et al.
(författare)
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Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18
- 2006
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Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 24:27-28, s. 5571-5583
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Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.
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- Monoranu, Camelia Maria, et al.
(författare)
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pH measurement as quality control on human post mortem brain tissue : a study of the BrainNet Europe consortium
- 2009
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Ingår i: Neuropathology and Applied Neurobiology. - : Wiley. - 0305-1846 .- 1365-2990. ; 35:3, s. 329-337
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Most brain diseases are complex entities. Although animal models or cell culture experiments mimic some disease aspects, human post mortem brain tissue remains essential to advance our understanding of brain diseases using biochemical and molecular techniques. Post mortem artefacts must be properly understood, standardized, and either eliminated or factored into such experiments. Here we examine the influence of several premortem and post mortem factors on pH, and discuss the role of pH as a biochemical marker for brain tissue quality. METHODS: We assessed brain tissue pH in 339 samples from 116 brains provided by 8 different European and 2 Australian brain bank centres. We correlated brain pH with tissue source, post mortem delay, age, gender, freezing method, storage duration, agonal state and brain ischaemia. RESULTS: Our results revealed that only prolonged agonal state and ischaemic brain damage influenced brain tissue pH next to repeated freeze/thaw cycles. CONCLUSIONS: pH measurement in brain tissue is a good indicator of premortem events in brain tissue and it signals limitations for post mortem investigations.
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- Sundqvist, J. O., et al.
(författare)
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MgI emission lines at 12 and 18 mu m in K giants
- 2008
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 486:3, s. 985-993
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Tidskriftsartikel (refereegranskat)abstract
- Context. The solar mid-infrared metallic emission lines have already been observed and analyzed well, and the formation scenario of the Mg I 12 mu m lines has been known for more than a decade. Detections of stellar emission at 12 mu m have, however, been limited to Mg I in very few objects. Previous modeling attempts have been made only for Procyon and two cool evolved stars, with unsatisfactory results for the latter. This prevents the lines' long predicted usage as probes of stellar magnetic fields. Aims. We want to explain our observed Mg I emission lines at 12 mu m in the K giants Pollux, Arcturus, and Aldebaran and at 18 mu m in Pollux and Arcturus. We discuss our modeling of these lines and particularly how various aspects of the model atom affect the emergent line profiles. Methods. High-resolution observational spectra were obtained using TEXES at Gemini North and the IRTF. To produce synthetic line spectra, we employed standard one-dimensional, plane-parallel, non-LTE modeling for trace elements in cool stellar atmospheres. We computed model atmospheres with the MARCS code, applied a comprehensive magnesium model atom, and used the radiative transfer code MULTI to solve for the magnesium occupation numbers in statistical equilibrium. Results. The Mg I emission lines at 12 mu m in the K giants are stronger than in the dwarfs observed so far. We present the first observed stellar emission lines from Mg I at 18 mu m and from Al I, Si I, and presumably Ca I at 12 mu m. We successfully reproduce the observed Mg I emission lines simultaneously in the giants and in the Sun, but show how the computed line profiles depend critically on atomic data input and how the inclusion of energy levels with n > ;= 10 and collisions with neutral hydrogen are necessary to obtain reasonable fits.
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