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Träfflista för sökning "WFRF:(Heikkilä R) srt2:(2000-2004)"

Sökning: WFRF:(Heikkilä R) > (2000-2004)

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Numrering	Referens	Omslagsbild	Hitta
1.	Kainu, T, et al. (författare) Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus 2000 Ingår i: Proceedings of the National Academy of Sciences. - 1091-6490. ; 97:17, s. 9603-9608 Tidskriftsartikel (refereegranskat)abstract A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. Comparative genomic hybridization was used to study 61 breast tumors from 37 breast cancer families with no identified BRCA1 or BRCA2 mutations. Branching and phylogenetic tree models predicted that loss of 13q was one of the earliest genetic events in hereditary cancers. In a Swedish family with five breast cancer cases, all analyzed tumors showed distinct 13q deletions, with the minimal region of loss at 13q21-q22. Genotyping revealed segregation of a shared 13q21 germ-line haplotype in the family. Targeted linkage analysis was carried out in a set of 77 Finnish, Icelandic, and Swedish breast cancer families with no detected BRCA1 and BRCA2 mutations. A maximum parametric two-point logarithm of odds score of 2.76 was obtained for a marker at 13q21 (D13S1308, theta = 0.10). The multipoint logarithm of odds score under heterogeneity was 3.46. The results were further evaluated by simulation to assess the probability of obtaining significant evidence in favor of linkage by chance as well as to take into account the possible influence of the BRCA2 locus, located at a recombination fraction of 0.25 from the new locus. The simulation substantiated the evidence of linkage at D13S1308 (P < 0.0017). The results warrant studies of this putative breast cancer predisposition locus in other populations.
2.	Jaarsma, Tiny, et al. (författare) A survey of coronary risk factors and B-type natriuretic peptide concentrations in cardiac nurses from Europe : do nurses still practice what they preach? 2004 Ingår i: European Journal of Cardiovascular Nursing. - : Oxford University Press (OUP). - 1474-5151 .- 1873-1953. ; 3, s. 3-6 Tidskriftsartikel (refereegranskat)
3.	M´Saoubi, R.M., et al. (författare) Adhesion and friction in sliding contact between stainless steel and cemented carbides 2004 Ingår i: ICTP, 2004. Konferensbidrag (populärvet., debatt m.m.)
4.	Sörgaard, K W, et al. (författare) Predictors of social relations in persons with schizophrenia living in the community : a Nordic multicentre study. 2001 Ingår i: Social Psychiatry and Psychiatric Epidemiology. - 0933-7954 .- 1433-9285. ; 36:1, s. 13-9 Tidskriftsartikel (refereegranskat)abstract Living in urban areas, being female, having a high GAF score and low scores on hostility predicted better integration in terms of number of contacts and emotional relations.

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Resultat 1-4 av 4

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Typ av publikation: tidskriftsartikel (3); konferensbidrag (1)

Typ av innehåll: refereegranskat (3); populärvet., debatt m.m. (1)

Författare/redaktör: Olsson, Håkan (1); Eerola, Hannaleena (1); Nevanlinna, Heli (1); Heikkilä, Päivi (1); Strömberg, Anna (1); Jaarsma, Tiny (1); visa fler...; Hansson, L (1); Wiklund, Urban (1); Weaver, D. (1); Johannsson, Oskar (1); Mårtensson, Jan (1); Borg, Åke (1); Stewart, Simon (1); Fridlund, Bengt (1); Holli, K (1); Sandlund, Mikael (1); Heikkilä, Irma (1); Syrjakoski, K (1); Kallioniemi, O P (1); Holmberg, Eva (1); De Geest, Sabina (1); Fernandez, A (1); Smith, Karen (1); Op Reimer, Wilma Sch ... (1); Thompson, David R (1); Vehmanen, Paula (1); Egilsson, Valgardur (1); Arason, A (1); Pyrhönen, Seppo (1); Bengtsson-Tops, A (1); Bjarnason, O (1); Merinder, L (1); Middelboe, T (1); Törngren, Therese (1); Koivisto, P. (1); Moons, Philip (1); Bailey-Wilson, J (1); Heikkilä, Johanna (1); Heikkilä, J (1); Gillanders, E (1); Karhu, R (1); Johannsdottir, Hrefn ... (1); Stephan, D. (1); Freas-Lutz, D (1); Haraldsson, Karin (1); Vinding, H R (1); Sørgaard, K W (1); Kainu, T (1); Bergthorsson, Jon Th ... (1); Johannesdottir, G (1); visa färre...

Lärosäte: Umeå universitet (1); Uppsala universitet (1); Linköpings universitet (1); Jönköping University (1); Lunds universitet (1); Linnéuniversitetet (1)

Språk: Engelska (4)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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