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| 2. |
- Bondarenko, Artem, 1992-, et al.
(författare)
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Chaotic dynamics in spin-vortex pairs
- 2019
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Ingår i: Physical Review B. - 2469-9950 .- 2469-9969. ; 99
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Tidskriftsartikel (refereegranskat)abstract
- We report on spin-vortex pair dynamics measured at temperatures low enough to suppress stochastic core motion, thereby uncovering the highly nonlinear intrinsic dynamics of the system. Our analysis shows that the decoupling of the two vortex cores is resonant and can be enhanced by dynamic chaos. We detail the regions of the relevant parameter space, in which the various mechanisms of the resonant core-core dynamics are activated. We show that the presence of chaos can reduce the thermally induced spread in the decoupling time by up to two orders of magnitude.
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| 3. |
- Bondarenko, Artem, 1992-, et al.
(författare)
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Stochastic dynamics of strongly-bound magnetic vortex pairs
- 2017
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Ingår i: AIP Advances. - : American Institute of Physics (AIP). - 2158-3226. ; 7:5
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Tidskriftsartikel (refereegranskat)abstract
- We demonstrate that strongly-bound spin-vortex pairs exhibit pronounced stochastic behaviour. Such dynamics is due to collective magnetization states originating from purely dipolar interactions between the vortices. The resulting thermal noise exhibits telegraph-like behaviour, with random switching between different oscillation regimes observable at room temperature. The noise in the system is further studied by varying the external field and observing the related changes in the frequency of switching and the probability for different magnetic states and regimes. Monte Carlo simulations are used to replicate and explain the experimental observations.
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| 4. |
- Davitt, C. J. H., et al.
(författare)
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Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines
- 2019
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Ingår i: Mucosal Immunology. - : Elsevier BV. - 1933-0219. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3–4 million cases globally with 100,000–150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water and improved sanitation and hygiene, ideally in conjunction with oral vaccination. However, difficulties associated with the costs and logistics of these strategies have hampered their widespread implementation. Specific challenges pertaining to oral cholera vaccines (OCVs) include a lack of safe and effective adjuvants to further enhance gut immune responses, the complex and costly multicomponent vaccine manufacturing, limitations of conventional liquid formulation and the lack of an integrated delivery platform. Herein we describe the use of the orally active adjuvant α-Galactosylceramide (α-GalCer) to strongly enhance intestinal bacterium- and toxin-specific IgA responses to the OCV, Dukoral ® in C57BL/6 and BALB/c mice. We further demonstrate the mucosal immunogenicity of a novel multi-antigen, single-component whole-cell killed V. cholerae strain and the enhancement of its immunogenicity by adding α-GalCer. Finally, we report that combining these components and recombinant cholera toxin B subunit in the SmPill ® minisphere delivery system induced strong intestinal and systemic antigen-specific antibody responses. © 2019, The Author(s).
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| 5. |
- Ho, Doris M.L., et al.
(författare)
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Overall approaches and experiences of first-time participants in the Nuclear Forensics International Technical Working Group’s Fourth Collaborative Material Exercise (CMX-4)
- 2018
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 315:2, s. 353-363
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Tidskriftsartikel (refereegranskat)abstract
- The Fourth Collaborative Material Exercise (CMX-4) of the Nuclear Forensics International Technical Working Group (ITWG) registered the largest participation for this exercise in nuclear forensics, with seven of the 17 laboratories participating for the first time. Each of the laboratories had their strategic role to play in its respective country, analyzing real-world samples using their in-house resources. The scenario was fictitious but was thoughtfully crafted to engage participants in nuclear forensic investigations. In this paper, participants from five of the first-time laboratories shared their individual experience in this exercise, from preparation to analysis of samples.
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| 6. |
- Holmgren, Erik, et al.
(författare)
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Resonant pinning spectroscopy with spin-vortex pairs
- 2018
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Ingår i: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 97:9
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Tidskriftsartikel (refereegranskat)abstract
- Vortex pairs in magnetic nanopillars with strongly coupled cores and pinning of one of the cores by a morphological defect, are used to perform resonant pinning spectroscopy, in which a microwave excitation applied to the nanopillar produces pinning or depinning of the cores only when the excitation is in resonance with the rotational or gyrational eigenmodes of the specific initial state of the core-core pair. The shift in the eigenmode frequencies between the pinned and depinned states is determined experimentally and explained theoretically, and illustrates the potential for multicore spin-vortex memory with resonant writing of information onto various stable vortex pair states. Further, it is shown how the same resonant spectroscopy techniques applied to a vortex pair can be used as a sensitive nanoscale probe for characterizing morphological defects in magnetic films.
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| 7. |
- Holmgren, Erik, et al.
(författare)
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Transient dynamics of strongly coupled spin vortex pairs : Effects of anharmonicity and resonant excitation on inertial switching
- 2018
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Ingår i: Applied Physics Letters. - : AMER INST PHYSICS. - 0003-6951 .- 1077-3118. ; 112:19
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Tidskriftsartikel (refereegranskat)abstract
- Spin vortices in magnetic nanopillars are used as GHz oscillators, with frequency however essentially fixed in fabrication. We demonstrate a model system of a two-vortex nanopillar, in which the resonance frequency can be changed by an order of magnitude, without using high dc magnetic fields. The effect is due to switching between the two stable states of the vortex pair, and we show that it can be done with low-amplitude fields of sub-ns duration. We detail the relevant vortex-core dynamics and explain how field anharmonicity and phase control can be used to enhance the performance.
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| 8. |
- Holmgren Melin, Karin, et al.
(författare)
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Treatment and 12-month outcome of children and adolescents with obsessive-compulsive disorder: A naturalistic study
- 2015
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Ingår i: Journal of Obsessive-Compulsive and Related Disorders. - Amsterdam : Elsevier BV. - 2211-3649 .- 2211-3657. ; 6, s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- Pediatric obsessive-compulsive disorder (OCD) is a disorder associated with distress and impairment in many domains. Moreover, there is a high risk of relapse and developing a chronic illness. Randomized-controlled trails (RCT), the gold-standard for evaluating treatments, show treatments to be efficacious, yet little is known about their generalizability and long-term durability in "usual-care" settings. The aim of the present study is to evaluate the feasibility and effectiveness of evidence-based pediatric OCD-treatments in regular practice. Participants were 109 children (aged 7-17 years) with a primary diagnosis of OCD, recruited from a specialized OCD-clinic in Sweden. Few exclusion criteria were applied. The youths were assessed at baseline, 6 and 12 months following the first assessment, using Children's Yale-Brown Obsessive Compulsive Scale and Children's OCD Impact Scale. They were treated with Cognitive Behavior Therapy, augmented with SSRI when indicated. The majority responded well to treatment i.e. were free from OCD or in remission at 12 month evaluation. Moreover, the participants psychosocial functioning significantly improved from baseline to evaluation at 6 and 12 months. (C) 2015 Elsevier Inc. All rights reserved.
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| 9. |
- Ramebäck, Henrik, 1967, et al.
(författare)
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On the accuracy of gamma spectrometric isotope ratio measurements of uranium
- 2016
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Ingår i: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002. ; 815, s. 57-61
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Tidskriftsartikel (refereegranskat)abstract
- The isotopic composition of uranium was measured using high resolution gamma spectrometry. Two acid solutions and two samples in the form of UO2 pellets were measured. The measurements were done in close geometries, i.e. directly on the endcap of the high purity germanium detector (HPGe). Applying no corrections for count losses due to true coincidence summing (TCS) resulted in up to about 40% deviation in the abundance of U-235 from the results obtained with mass spectrometry. However, after correction for TCS, excellent agreement was achieved between the results obtained using two different measurement methods, or a certified value. Moreover, after corrections, the fitted relative response curves correlated excellently with simulated responses, for the different geometries, of the HPGe detector.
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| 10. |
- Ryösä, A., et al.
(författare)
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Acute Cuff Tear Repair Trial (ACCURATE) : Protocol for a multicentre, randomised, placebo-controlled trial on the efficacy of arthroscopic rotator cuff repair
- 2019
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Rotator cuff tear is a very common and disabling condition that can be related to acute trauma. Rotator cuff tear surgery is a well-established form of treatment in acute rotator cuff tears. Despite its widespread use and almost a gold standard position, the efficacy of an arthroscopic rotator cuff repair is still unknown. The objective of this trial is to investigate the difference in outcome between arthroscopic rotator cuff repair and inspection of the shoulder joint defined as placebo surgery in patients 45–70 years of age with an acute rotator tear related to trauma.Methods and analysis Acute Cuff Tear Repair Trial (ACCURATE) is a randomised, placebo-controlled, multicentre efficacy trial with sample size of 180 patients. Concealed allocation is done in 1:1 ratio. The randomisation is stratified according to participating hospital, gender and baseline Western Ontario Rotator Cuff Index (WORC). Both groups receive the same standardised postoperative treatment and physiotherapy. The primary outcome measure is the change in WORC score from baseline to 2-year follow-up. Secondary outcome measures include Constant-Murley Score, the Numerical Rating Scale for pain, subjective patient satisfaction and the health-related quality of life instrument 15 dimensions (15D). Patients and outcome assessors are blinded from the allocated intervention. The primary analysis of results will be conducted according to intention-to-treat analysis.Ethics and dissemination The study protocol for this clinical trial has been approved by the Ethics Committee of the Hospital District of Southwest Finland and Regional Ethics Committee in Linköping Sweden and Regional Committees for Medical and Health Research Ethics South East in Norway. Every recruiting centre will apply local research approvals. The results of this study will be submitted for publication in peer-reviewed journals.
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