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The impact of acute...
The impact of acute and short-term methamphetamine abstinence on brain metabolites : A proton magnetic resonance spectroscopy chemical shift imaging study
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- Burger, Antoinette (författare)
- Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa
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- Brooks, Samantha J. (författare)
- Uppsala universitet,Funktionell farmakologi,Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa
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- Stein, Dan J. (författare)
- Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa
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- Howells, Fleur M. (författare)
- Univ Cape Town, Groote Schuur Hosp, Dept Psychiat & Mental Hlth, Anzio Rd, ZA-7925 Cape Town, South Africa;Univ Cape Town, Inst Neurosci, Cape Town, South Africa
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Drug And Alcohol Dependence. - : Elsevier BV. - 0376-8716 .- 1879-0046. ; 185, s. 226-237
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BackgroundAbuse of methamphetamine (MA) is a global health concern. Previous H-1-MRS studies have found that, with methamphetamine abstinence (MAA), there are changes in n-acetyl-aspartate (NAA/Cr), myo-inositol (mI/Cr), choline (Cho/Cr and Cho/NAA), and glutamate with glutamine (Glx) metabolites. Limited studies have investigated the effect of acute MAA, and acute-to-short-term MAA on brain metabolites.MethodsAdults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited. Two-dimensional chemical shift H-1-MRS imaging (TR2000 ms, TE30 ms) slice was performed and included voxels in bilateral anterior-cingulate (ACC), frontal-white-matter (FWM), and dorsolateral-prefrontal-cortices (DLPFC). Control participants were scanned once. The MA group was scanned twice, with acute (1.5 +/- 0.6 weeks, n = 31) and short-term MAA (5.1 +/- 0.8 weeks, n = 22). The change in H-1-MRS metabolites over time (n = 19) was also investigated. Standard H-1-MRS metabolites are reported relative to Cr + PCr.ResultsAcute MAA showed lower n-acetyl-aspartate (NAA) and n-acetyl-aspartate with n-acetyl-aspartyl-glutamate (NAA + NAAG) in left DLPFC, and glycerophosphocholine with phosphocholine (GPC + PCh) in left FWM. Short-term MAA showed lower NAA + NAAG and higher myo-inositol (mI) in right ACC, lower NAA and NAA + NAAG in the left DLPFC, and lower GPC + PCh in left FWM. Over time, MAA showed decreased NAA and NAA + NAAG and increased mI in right ACC, decreased NAA and NAA + NAAG in right FWM, and decreased in mI in left FWM.ConclusionIn acute MAA, there was damage to the integrity of neuronal tissue, which was enhanced with short-term MAA. From acute to short-term MAA, activation of neuroinflammatory processes are suggested. This is the first H-1-MRS study to report the development of neuroinflammation with loss of neuronal integrity in MAA.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Samhällsbyggnadsteknik -- Transportteknik och logistik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Civil Engineering -- Transport Systems and Logistics (hsv//eng)
Nyckelord
- Methamphetamine abstinence
- H-1-MRS
- Neuroinflammation
- Neuroimaging
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- ref (ämneskategori)
- art (ämneskategori)
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