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- Fröjmark, Anders
(författare)
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Mirakler och helgonkult : Linköpings biskopdöme under senmedeltid
- 1992
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This work studies the introduction of three new cults of saints in the Linköping Bishopric during the Late Middle Ages. Two of them were based at Vadstena Convent: the Holy Bridgel (Birgitta, d. 1373) cult which had its beginning in 1374 and the cult of Katarina Ulfsdotter (d. 1381), which started during the 1410's. The third, the cult of Bishop Nils Hermansson (d. 1391), which originated at the latest in I40l. was associaled w ith the cathedral in Linköping.The introduction of a saint's cult may be relaled to the need of many people in medieval society for healing and protection. The tales about the saint's posthumous miracles played a key role in the introductory phase of the cults. In the dissertation such tales are used as the foundation for the analysis of the varied geographic and social patterns of distnbution of the three cults.The cult of the Holy Bridget was as much an intemational as a Swedish cult. The other cults studied were two of manv attempts to ride on the wave created by the successes of the Bridget cult. They may furthermore be regarded a response to various types of crises which the sponsoring institutions experienced.
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| 3. |
- Sjogren-Jansson, Eva, et al.
(författare)
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Production of human monoclonal antibodies in dialysis tubing
- 1991
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Ingår i: Hybridoma. - : Mary Ann Liebert Inc. - 0272-457X. ; 10:3, s. 411-419
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Tidskriftsartikel (refereegranskat)abstract
- Human x mouse hybridoma cells were grown in dialysis tubing (DT) to obtain large quantities of human monoclonal antibodies (MAb). Hybridoma cells were grown inside the DT, which was placed in a tissue culture flask containing medium. The medium inside the DT was supplemented with different additives which may be selected depending on the intended use of the MAb. About 10-50 times higher concentrations of immunoglobulin (Ig) were obtained after cultivation in DT compared to conventional tissue culture (CTC) for 2 days. The purity of the MAb was high which facilitated further antibody purification. Production of human MAb in DT proved to be excellent for evaluation studies in laboratory scale. It does not require expensive equipment and several hybridomas can be grown simultaneously.
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| 4. |
- Sylvén, Christer, et al.
(författare)
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Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy.
- 1993
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Ingår i: Cardiovascular research. - 0008-6363. ; 27:7, s. 1295-9
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: A disturbed energy transfer involving the adenine nucleotide translocator across the inner mitochondrial membrane has been suggested to be one specific pathogenetic mechanism in dilated cardiomyopathy. Pretranslational steady state expression of this protein in dilated cardiomyopathy was investigated. METHODS: Concentrations of adenine nucleotide translocator were quantified by solution hybridisation. The enzyme or protein expressions of citrate synthase, lactate dehydrogenase, and creatine kinase with isozymes were determined. Analysis was performed on specimens from the left and right ventricles from six organ donor hearts, six explanted hearts with dilated cardiomyopathy, two explanted hearts with ischaemic cardiomyopathy, and from papillary muscles from seven patients operated on for mitral regurgitation. RESULTS: The ejection fraction in patients with mitral regurgitation was 50(10)%, significantly higher (p < 0.001) than in patients with dilated cardiomyopathy (23(5))%. In mitral regurgitation and in ischaemic cardiomyopathy left ventricular adenine nucleotide translocator mRNA concentrations did not differ from those in donor hearts. In dilated cardiomyopathy, adenine nucleotide translocator mRNA concentrations were significantly increased (p < 0.001). Upregulation was more pronounced in right ventricular than in left ventricular myocardium (p < 0.01). The lactate dehydrogenase M subunit fraction was increased to a similar degree in dilated cardiomyopathy and in mitral regurgitation (p < 0.05). Citrate synthase activity was significantly decreased only in dilated cardiomyopathy (p < 0.005). On the other hand, the creatine kinase B subunit content was significantly higher in mitral regurgitation than in dilated cardiomyopathy (p < 0.001). CONCLUSIONS: Despite signs of increased anaerobic and depressed oxidative capacities, dilated cardiomyopathy was specifically characterised by pretranslational upregulation of adenine nucleotide translocator.
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